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Institutional Holdings

GPCR

Ownership Summary

Institutions Holding
246
Total Shares Held
74,275,494
Total Value Held
$4,920,273,736
Quarter
2025-12-31

Active Positions

Increased Positions
17
1,760,276 shares
Decreased Positions
9
269,477 shares
Held Positions
11
625,044 shares
New Positions
196
71,620,697 shares
Sold Out Positions
13
1,203,709 shares
Institution Shares Value Change % of Portfolio Reported
FMR LLC 8,712,251 $605,937,057 New position 2025-12-31
WELLINGTON MANAGEMENT GROUP LLP 7,121,984 $495,333,988 New position 2025-12-31
Avoro Capital Advisors LLC 6,555,555 $455,938,850 New position 2025-12-31
Jupiter Topco LLC 5,204,212 $279,339,383 New position 0.11% 2026-06-30
Deep Track Capital, LP 4,111,782 $285,974,438 New position 2025-12-31
BVF INC/IL 3,479,022 $241,965,980 New position 2025-12-31
MORGAN STANLEY 2,087,834 $145,208,903 New position 2025-12-31
ORBIMED ADVISORS LLC 1,161,803 $80,803,399 New position 2025-12-31
PRINCIPAL FINANCIAL GROUP INC 1,284,210 $89,316,805 New position 2025-12-31
AMERICAN CENTURY COMPANIES INC 506,959 $35,259,464 New position 2025-12-31
RTW INVESTMENTS, LP 100,000 $6,955,000 New position 2025-12-31
DRIEHAUS CAPITAL MANAGEMENT LLC 1,642,444 $114,231,980 New position 2025-12-31
BAKER BROS. ADVISORS LP 1,432,529 $99,632,392 New position 2025-12-31
Casdin Capital, LLC 1,175,000 $81,721,250 New position 2025-12-31
DEERFIELD MANAGEMENT COMPANY, L.P. 767,993 $53,413,913 New position 2025-12-31
CAPITOLIS LIQUID GLOBAL MARKETS LLC 878,300 $61,085,765 New position 2025-12-31
Siren, L.L.C. 1,078,698 $75,023,446 New position 2025-12-31
PACIFIC HEIGHTS ASSET MANAGEMENT LLC 700,000 $48,685,000 New position 2025-12-31
Rock Springs Capital Management LP 748,236 $52,039,814 New position 2025-12-31
Aberdeen Group plc 639,915 $34,344,238 ▲ +248,106 0.05% 2026-06-30
FRANKLIN RESOURCES INC 870,582 $60,548,961 New position 2025-12-31
BANK OF AMERICA CORP /DE/ 31,678 $2,203,205 ▲ +17,899 2025-12-31
ALLIANCEBERNSTEIN L.P. 848,851 $59,037,587 New position 2025-12-31
BlackRock, Inc. 430,082 $29,912,204 New position 2025-12-31
Logos Global Management LP 600,000 $41,730,000 New position 2025-12-31
Parkman Healthcare Partners LLC 55,000 $3,825,250 New position 2025-12-31
Davern Capital Partners, LP 446,059 $23,939,987 ▲ +319,598 4.08% 2026-06-30
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 467,800 $32,535,490 New position 2025-12-31
GOLDMAN SACHS GROUP INC 397,832 $27,669,215 New position 2025-12-31
UBS Group AG 202,877 $14,110,096 New position 2025-12-31
DEUTSCHE BANK AG TAUNUSANLAGE 12 D-60325 331,867 $17,811,302 Unchanged 0.01% 2026-06-30
NEXTBio Capital Management LP 94,443 $6,568,511 New position 2025-12-31
SUSQUEHANNA INTERNATIONAL GROUP, LLP 368,799 $25,649,970 New position 2025-12-31
Catalio Capital Management, LP 252,901 $17,589,265 New position 2025-12-31
HSG Holding Ltd 266,062 $24,443,116 New position 2025-12-31
SEB Asset Management AB 245,043 $13,151,433 Unchanged 0.05% 2026-06-30
AMERIPRISE FINANCIAL INC 285,518 $19,857,777 New position 2025-12-31
NATIONAL BANK OF CANADA /FI/ 265,400 $18,458,570 New position 2025-12-31
TWO SIGMA INVESTMENTS, LP 95,543 $6,645,016 New position 2025-12-31
Eversept Partners, LP 127,561 $8,871,868 New position 2025-12-31
Schonfeld Strategic Advisors LLC 8,727 $606,962 New position 2025-12-31
Woodline Partners LP 123,902 $8,617,384 New position 2025-12-31
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 82,645 $5,748,000 New position 2025-12-31
ArrowMark Colorado Holdings LLC 271,213 $18,862,864 New position 2025-12-31
Susquehanna Portfolio Strategies, LLC 68,089 $4,735,590 New position 2025-12-31
CenterBook Partners LP 148,030 $7,944,770 ▲ +126,793 0.39% 2026-06-30
Rhenman & Partners Asset Management AB 147,600 $10,265,580 New position 2025-12-31
B Group, Inc. 90,000 $6,259,500 New position 2025-12-31
HighVista Strategies LLC 193,001 $13,423,219 New position 2025-12-31
CITADEL ADVISORS LLC 906,618 $63,055,282 New position 2025-12-31
Universal- Beteiligungs- und Servicegesellschaft mbH 83,052 $5,776,266 New position 2025-12-31
Squarepoint Ops LLC 125,575 $6,739,610 ▲ +102,929 0.01% 2026-06-30
D. E. Shaw & Co., Inc. 8,623 $599,730 New position 2025-12-31
VOLORIDGE INVESTMENT MANAGEMENT, LLC 250,000 $17,387,500 New position 2025-12-31
Soleus Capital Management, L.P. 90,000 $6,259,500 New position 2025-12-31
Avidity Partners Management LP 98,000 $5,259,660 ▲ +68,000 0.84% 2026-06-30
GEODE CAPITAL MANAGEMENT, LLC 55,148 $3,835,543 New position 2025-12-31
Qube Research & Technologies Ltd 93,403 $5,012,939 ▲ +19,804 0.00% 2026-06-30
PEREGRINE CAPITAL MANAGEMENT LLC 84,324 $5,864,734 New position 2025-12-31
PFM Health Sciences, LP 68,248 $4,746,648 New position 2025-12-31
PLATINUM INVESTMENT MANAGEMENT LTD 87,874 $6,111,637 New position 2025-12-31
MILLENNIUM MANAGEMENT LLC 152,560 $10,610,548 New position 2025-12-31
ExodusPoint Capital Management, LP 78,266 $4,200,536 New position 0.03% 2026-06-30
ADAGE CAPITAL PARTNERS GP, L.L.C. 75,000 $4,025,250 New position 0.01% 2026-06-30
Cormorant Asset Management, LP 75,000 $4,025,250 ▼ -100,000 0.21% 2026-06-30
Boxer Capital Management, LLC 75,000 $5,216,250 New position 2025-12-31
ALPS ADVISORS INC 49,726 $3,458,443 New position 2025-12-31
TD ASSET MANAGEMENT INC 174,674 $12,148,577 New position 2025-12-31
JANE STREET GROUP, LLC 220,717 $15,350,867 New position 2025-12-31
IMC-Chicago, LLC 62,118 $3,333,873 New position 0.00% 2026-06-30
Brevan Howard Capital Management LP 86,310 $5,957,116 New position 2025-12-31
Burkehill Global Management, LP 60,000 $4,173,000 New position 2025-12-31
RAYMOND JAMES FINANCIAL INC 44,388 $3,087,184 New position 2025-12-31
ANTIPODES PARTNERS Ltd 46,291 $3,246,444 New position 2025-12-31
SCOGGIN MANAGEMENT LP 50,000 $2,683,500 New position 0.29% 2026-06-30
SEVEN GRAND MANAGERS, LLC 50,000 $3,477,500 New position 2025-12-31
Buckland Partners Management Co LLC 50,000 $3,477,500 New position 2025-12-31
DAFNA Capital Management LLC 37,000 $2,573,350 New position 2025-12-31
Mariner, LLC 44,155 $3,070,980 New position 2025-12-31
OSAIC HOLDINGS, INC. 59,238 $4,119,944 New position 2025-12-31
STATE STREET CORP 48,224 $3,353,979 New position 2025-12-31
VOYA INVESTMENT MANAGEMENT LLC 55,300 $3,846,115 New position 2025-12-31
BANQUE PICTET & CIE SA 43,332 $2,325,628 ▼ -6,035 0.01% 2026-06-30
Jump Financial, LLC 42,658 $2,289,455 ▼ -65,199 0.02% 2026-06-30
BANK OF MONTREAL /CAN/ 54,341 $3,683,233 New position 2025-12-31
Cinctive Capital Management LP 40,877 $2,193,869 ▲ +32,163 0.08% 2026-06-30
Jefferies Financial Group Inc. 102,993 $7,163,163 New position 2025-12-31
Jones Hill Capital LP 40,567 $2,177,231 ▼ -60,026 0.46% 2026-06-30
STEMPOINT CAPITAL LP 351,073 $24,417,127 New position 2025-12-31
MANUFACTURERS LIFE INSURANCE COMPANY, THE 96,387 $6,533,111 New position 2025-12-31
PSquared Asset Management AG 37,200 $1,996,524 ▲ +2,200 0.65% 2026-06-30
FLAX POND CAPITAL, LLC 36,000 $1,932,120 Unchanged 1.35% 2026-06-30
TrueMark Investments, LLC 33,600 $1,803,312 ▼ -777 0.23% 2026-06-30
NOMURA ASSET MANAGEMENT CO LTD 29,152 $2,027,522 New position 2025-12-31
DCF Advisers, LLC 30,000 $2,086,500 New position 2025-12-31
EXCHANGE TRADED CONCEPTS, LLC 30,773 $1,651,587 ▲ +5,395 0.01% 2026-06-30
SPHERA FUNDS MANAGEMENT LTD. 41,000 $2,851,550 New position 2025-12-31
Verition Fund Management LLC 78,149 $5,435,263 New position 2025-12-31
Y-Intercept (Hong Kong) Ltd 10,132 $704,681 New position 2025-12-31
Seven Fleet Capital Management LP 26,800 $1,441,572 ▲ +17,800 0.24% 2026-06-30
MML INVESTORS SERVICES, LLC 7,825 $544,229 New position 2025-12-31
Birchview Capital, LP 90,000 $6,259,500 New position 2025-12-31
NOMURA HOLDINGS INC 22,873 $1,227,594 New position 0.00% 2026-06-30
SIMPLEX TRADING, LLC 92,668 $6,445,059 New position 2025-12-31
GROUP ONE TRADING LLC 20,600 $1,105,602 ▼ -39,400 0.00% 2026-06-30
BARCLAYS PLC 7,833 $544,786 New position 2025-12-31
BNP PARIBAS FINANCIAL MARKETS 8,746 $608,284 New position 2025-12-31
ADAR1 Capital Management, LLC 17,500 $939,225 New position 0.04% 2026-06-30
STIFEL FINANCIAL CORP 4,830 $335,932 New position 2025-12-31
LPL Financial LLC 8,109 $563,981 New position 2025-12-31
WEXFORD CAPITAL LP 14,835 $1,031,770 New position 2025-12-31
SEI INVESTMENTS CO 14,903 $1,036,507 New position 2025-12-31
BRANDYWINE MANAGERS, LLC 13,357 $928,979 New position 2025-12-31
Gladstone Institutional Advisory LLC 13,275 $712,469 New position 0.02% 2026-06-30
China Universal Asset Management Co., Ltd. 10,888 $757,260 New position 2025-12-31
ENVESTNET ASSET MANAGEMENT INC 11,570 $804,694 New position 2025-12-31
Verdad Advisers, LP 11,335 $608,349 Unchanged 0.58% 2026-06-30
DnB Asset Management AS 12,639 $879,042 New position 2025-12-31
FOX RUN MANAGEMENT, L.L.C. 10,776 $578,348 New position 0.10% 2026-06-30
WELLS FARGO & COMPANY/MN 5,664 $393,896 New position 2025-12-31
Quinn Opportunity Partners LLC 25,000 $1,738,750 New position 2025-12-31
SmartHarvest Portfolios, LLC 9,056 $629,845 New position 2025-12-31
CITIGROUP INC 7,335 $510,149 New position 2025-12-31
Gilbert & Cook, Inc. 9,167 $491,993 ▼ -26 0.06% 2026-06-30
Clearstead Advisors, LLC 7,826 $420,021 New position 0.00% 2026-06-30
Allianz Asset Management GmbH 12,000 $834,600 New position 2025-12-31
Quadcap Wealth Management, LLC 7,483 $354,774 New position 2025-12-31
Virtus Investment Advisers, LLC 3,967 $275,905 New position 2025-12-31
MISSION WEALTH MANAGEMENT, LP 9,583 $666,498 New position 2025-12-31
Vestmark Advisory Solutions, Inc. 7,534 $523,990 New position 2025-12-31
Cetera Investment Advisers 6,596 $458,752 New position 2025-12-31
EntryPoint Capital, LLC 6,136 $329,319 New position 0.08% 2026-06-30
Mirae Asset Global Investments Co., Ltd. 10,534 $732,640 New position 2025-12-31
NORTHERN TRUST CORP 3,645 $253,509 New position 2025-12-31
Concurrent Investment Advisors, LLC 5,000 $347,750 New position 2025-12-31
Bellevue Group AG 145,167 $10,096,365 New position 2025-12-31
Arrowpoint Investment Partners (Singapore) Pte. Ltd. 4,645 $249,297 ▲ +455 0.05% 2026-06-30
Independent Advisor Alliance 4,543 $243,823 ▼ -2,901 0.01% 2026-06-30
SECTORAL ASSET MANAGEMENT INC 23,872 $1,660,298 New position 2025-12-31
PEAK6 LLC 7,955 $553,270 New position 2025-12-31
Walleye Trading LLC 72,900 $5,070,195 New position 2025-12-31
Prospera Financial Services Inc 4,100 $220,042 New position 0.00% 2026-06-30
GABELLI FUNDS LLC 4,000 $278,200 New position 2025-12-31
Invesco Ltd. 3,200 $222,560 New position 2025-12-31
JPMORGAN CHASE & CO 12,956 $901,090 New position 2025-12-31
NANO CAP NEW MILLENNIUM GROWTH FUND L P 3,500 $187,845 ▲ +2,000 0.14% 2026-06-30
State of Wyoming 1,761 $122,478 New position 2025-12-31
PNC FINANCIAL SERVICES GROUP, INC. 3,926 $273,053 New position 2025-12-31
ASSETMARK, INC 2,726 $146,304 ▲ +182 0.00% 2026-06-30
NATIXIS 2,482 $135,095 New position 0.00% 2026-06-30
Rockefeller Capital Management L.P. 731 $50,841 New position 2025-12-31
Sterling Capital Management LLC 2,045 $109,755 ▲ +1,455 0.00% 2026-06-30
GF FUND MANAGEMENT CO. LTD. 1,312 $91,250 New position 2025-12-31
Federation des caisses Desjardins du Quebec 1,500 $80,490 New position 0.00% 2026-06-30
Steward Partners Investment Advisory, LLC 2,540 $176,657 New position 2025-12-31
Tower Research Capital LLC (TRC) 41 $2,852 New position 2025-12-31
IFP Advisors, Inc 858 $46,049 New position 0.00% 2026-06-30
PRICE T ROWE ASSOCIATES INC /MD/ 1,671,138 $116,228 New position 2025-12-31
ROYAL BANK OF CANADA 10,200 $709,000 New position 2025-12-31
SUMMIT SECURITIES GROUP LLC 500 $26,835 New position 0.00% 2026-06-30
WOLFF WIESE MAGANA LLC 400 $21,468 Unchanged 0.01% 2026-06-30
Zurcher Kantonalbank (Zurich Cantonalbank) 385 $20,663 ▲ +173 0.00% 2026-06-30
Integrated Wealth Concepts LLC 271 $14,549 New position 0.00% 2026-06-30
Quarry LP 245 $13,149 New position 0.00% 2026-06-30
JONES FINANCIAL COMPANIES LLLP 1,046 $72,749 New position 2025-12-31
SIGNATUREFD, LLC 100 $5,367 Unchanged 0.00% 2026-06-30
Key Financial Inc 100 $5,367 Unchanged 0.00% 2026-06-30
SHP Wealth Management 100 $5,367 Unchanged 0.00% 2026-06-30
HUNTINGTON NATIONAL BANK 2 $139 New position 2025-12-31
Rakuten Securities, Inc. 60 $3,220 Unchanged 0.00% 2026-06-30
Arax Advisory Partners 34 $1,825 New position 0.00% 2026-06-30
GSA CAPITAL PARTNERS LLP 28,665 $1,538 ▲ +14,854 0.10% 2026-06-30
Transamerica Financial Advisors, LLC 22 $1,180 Unchanged 0.00% 2026-06-30
Smartleaf Asset Management LLC 17 $879 Unchanged 0.00% 2026-06-30
Caitong International Asset Management Co., Ltd 10 $537 ▼ -366 0.00% 2026-06-30
HRT FINANCIAL LP 6,200 $332 New position 0.00% 2026-06-30
Larson Financial Group LLC 5 $348 New position 2025-12-31
BESSEMER GROUP INC 29 $2 New position 2025-12-31
Capital Analysts, LLC 18 $1 New position 2025-12-31
Paradigm Biocapital Advisors LP 0 $0 Sold out 2026-06-30
BALYASNY ASSET MANAGEMENT L.P. 216,199 $15,036,640 New position 2025-12-31
Pentwater Capital Management LP 0 $0 Sold out 2026-06-30
Sio Capital Management, LLC 201,500 $14,014,325 New position 2025-12-31
DIADEMA PARTNERS LP 191,700 $13,332,735 New position 2025-12-31
Holocene Advisors, LP 0 $0 Sold out 2026-06-30
TCG Crossover Management, LLC 920,857 $64,045,604 New position 2025-12-31
SCHRODER INVESTMENT MANAGEMENT GROUP 0 $0 Sold out 2026-06-30
Trexquant Investment LP 89,945 $6,255,675 New position 2025-12-31
Blue Owl Capital Holdings LP 0 $0 Sold out 2026-06-30
RENAISSANCE TECHNOLOGIES LLC 115,200 $8,012,160 New position 2025-12-31
Monashee Investment Management LLC 225,000 $15,648,750 New position 2025-12-31
Pier Capital, LLC 48,757 $3,391,049 New position 2025-12-31
Walleye Capital LLC 26,502 $1,843,214 New position 2025-12-31
Headlands Technologies LLC 43,729 $3,041,352 New position 2025-12-31
XTX Topco Ltd 19,193 $1,334,873 New position 2025-12-31
Persistent Asset Partners Ltd 2,436 $169,424 New position 2025-12-31
Aquatic Capital Management LLC 0 $0 Sold out 2026-06-30
Russell Investments Group, Ltd. 26,274 $1,827,400 New position 2025-12-31
AXQ CAPITAL, LP 0 $0 Sold out 2026-06-30
Scientech Research LLC 0 $0 Sold out 2026-06-30
Jain Global LLC 99,996 $6,954,722 New position 2025-12-31
Tidal Investments LLC 0 $0 Sold out 2026-06-30
Penserra Capital Management LLC 0 $0 Sold out 2026-06-30
FARMERS & MERCHANTS INVESTMENTS INC 0 $0 Sold out 2026-06-30
US BANCORP DE U.S. BANCORP 0 $0 Sold out 2026-06-30
Allworth Financial LP 0 $0 Sold out 2026-06-30
JANUS HENDERSON GROUP PLC 5,090,148 $354,005,522 New position 2025-12-31
DEUTSCHE BANK AG\ 841,162 $58,502,817 New position 2025-12-31
FARALLON CAPITAL MANAGEMENT LLC 454,000 $31,575,700 New position 2025-12-31
EcoR1 Capital, LLC 334,380 $23,256,129 New position 2025-12-31
MARSHALL WACE, LLP 168,584 $11,725,016 New position 2025-12-31
Alyeska Investment Group, L.P. 115,000 $7,998,250 New position 2025-12-31
SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 99,617 $6,928,362 New position 2025-12-31
SummitTX Capital, L.P. 94,671 $6,584,368 New position 2025-12-31
Longaeva Partners L.P. 60,000 $4,173,000 New position 2025-12-31
Integral Health Asset Management, LLC 50,000 $3,477,500 New position 2025-12-31
ACT CAPITAL MANAGEMENT, LLC 38,500 $2,677,675 New position 2025-12-31
Informed Momentum Co LLC 38,054 $2,646,656 New position 2025-12-31
TUDOR INVESTMENT CORP ET AL 35,053 $2,437,936 New position 2025-12-31
Vestal Point Capital, LP 35,000 $2,434,250 New position 2025-12-31
Maven Securities LTD 20,000 $1,391,000 New position 2025-12-31
J. Goldman & Co LP 13,601 $945,950 New position 2025-12-31
Quadrature Capital Ltd 12,761 $887,528 New position 2025-12-31
Bleichroeder LP 10,000 $695,500 New position 2025-12-31
HighTower Advisors, LLC 9,320 $648,206 New position 2025-12-31
Merit Financial Group, LLC 7,376 $513,000 New position 2025-12-31
Parallel Advisors, LLC 7,352 $511,332 New position 2025-12-31
PSP Research LLC 6,719 $467,306 New position 2025-12-31
Blueshift Asset Management, LLC 5,213 $362,564 New position 2025-12-31
Ikarian Capital, LLC 4,824 $335,510 New position 2025-12-31
Bank of New York Mellon Corp 3,604 $250,635 New position 2025-12-31
PROFUND ADVISORS LLC 3,507 $243,912 New position 2025-12-31
CIBC WORLD MARKET INC. 3,248 $225,898 New position 2025-12-31
ProShare Advisors LLC 2,957 $205,659 New position 2025-12-31
Banque Cantonale Vaudoise 2,945 $205,000 New position 2025-12-31
Police & Firemen's Retirement System of New Jersey 1,829 $127,207 New position 2025-12-31
EverSource Wealth Advisors, LLC 578 $40,200 New position 2025-12-31
North Star Investment Management Corp. 330 $22,952 New position 2025-12-31
Dynamic Wealth Strategies, LLC 150 $10,433 New position 2025-12-31
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 60 $4,173 New position 2025-12-31
ACADIAN ASSET MANAGEMENT LLC 17,606 $1,224 New position 2025-12-31
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 17,297 $1,203 New position 2025-12-31
Janney Capital Management LLC 8,513 $592 New position 2025-12-31
CULLEN/FROST BANKERS, INC. 8 $556 New position 2025-12-31
CWM, LLC 960 $66 New position 2025-12-31
Daiwa Securities Group Inc. 186 $13 New position 2025-12-31