Paradigm Biocapital Advisors LP
CIK 0001855655
Annualised vol
16.897196%
Beta
0.302974
HHI
951.158081
Top-10 weight
75.210983%
VaR 95%
1.528498%
VaR 99%
2.87859%
Max drawdown
40.138649%
Matched value
79.18059%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| RVMD | REDUCED | 6,361,323 | 6,655,703 | -4.42% | 1,191,348,571 |
| EWTX | ADDED | 10,215,455 | 7,365,038 | 38.7% | 415,053,937 |
| GMAB | ADDED | 13,133,131 | 7,967,836 | 64.83% | 360,767,109 |
| SYRE | ADDED | 3,840,778 | 1,957,266 | 96.23% | 340,984,271 |
| ORKA | REDUCED | 2,144,526 | 2,320,316 | -7.58% | 204,094,539 |
| TNGX | ADDED | 6,357,523 | 4,009,679 | 58.55% | 198,736,169 |
| BLTE | ADDED | 1,232,877 | 1,114,784 | 10.59% | 189,844,565 |
| ERAS | REDUCED | 9,550,000 | 10,392,702 | -8.11% | 174,956,000 |
| TARS | ADDED | 2,775,649 | 2,562,154 | 8.33% | 174,699,348 |
| ALNY | NEW | 480,000 | - | - | 144,494,400 |
| INSM | ADDED | 1,325,977 | 1,254,488 | 5.7% | 141,375,668 |
| MBX | NEW | 2,508,015 | - | - | 138,442,428 |
| PCVX | REDUCED | 2,127,852 | 4,793,020 | -55.61% | 123,692,037 |
| OLMA | ADDED | 8,670,576 | 8,020,576 | 8.1% | 108,468,906 |
| JBIO | NEW | 2,857,405 | - | - | 63,491,539 |
| TYRA | REDUCED | 1,828,607 | 2,054,991 | -11.02% | 58,405,708 |
| ASMB | ADDED | 1,553,748 | 665,251 | 133.56% | 42,696,995 |
| EYPT | REDUCED | 2,890,397 | 3,142,437 | -8.02% | 41,332,677 |
| VOR | UNCHANGED | 1,750,000 | 1,750,000 | 0.0% | 32,217,500 |
| MPLT | NEW | 685,852 | - | - | 24,580,936 |
| KARD | NEW | 900,000 | - | - | 21,465,000 |
| LXEO | REDUCED | 4,175,382 | 6,184,134 | -32.48% | 19,436,403 |
| EDIT | NEW | 5,586,625 | - | - | 18,100,665 |
| MAZE | CLOSED OUT | 0 | 2,744,399 | -100.0% | 0 |
| URGN | CLOSED OUT | 0 | 1,703,949 | -100.0% | 0 |
| ORIC | CLOSED OUT | 0 | 1,701,217 | -100.0% | 0 |
| CYTK | CLOSED OUT | 0 | 1,480,857 | -100.0% | 0 |
| KLRS | CLOSED OUT | 0 | 700,000 | -100.0% | 0 |
| MIRM | CLOSED OUT | 0 | 625,000 | -100.0% | 0 |
| GPCR | CLOSED OUT | 0 | 545,287 | -100.0% | 0 |
| MANE | CLOSED OUT | 0 | 525,000 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| RVMD | REDUCED | REVOLUTION MEDICINES INC | COM | 76155X100 | 1,191,348,571 | 22.31 | 6361323.0 |
| - | NUVALENT INC | COM | 670703107 | 731,667,476 | 13.7 | 5924433.0 | |
| EWTX | ADDED | EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 415,053,937 | 7.77 | 1.0215455E7 |
| GMAB | ADDED | GENMAB A/S | SPONSORED ADS | 372303206 | 360,767,109 | 6.76 | 1.3133131E7 |
| SYRE | ADDED | SPYRE THERAPEUTICS INC | COM NEW | 00773J202 | 340,984,271 | 6.38 | 3840778.0 |
| - | APOGEE THERAPEUTICS INC | COM | 03770N101 | 209,233,581 | 3.92 | 1576385.0 | |
| ORKA | REDUCED | ORUKA THERAPEUTICS INC | COM | 687604108 | 204,094,539 | 3.82 | 2144526.0 |
| TNGX | ADDED | TANGO THERAPEUTICS INC | COM | 87583X109 | 198,736,169 | 3.72 | 6357523.0 |
| BLTE | ADDED | BELITE BIO INC | SPONSORED ADS | 07782B104 | 189,844,565 | 3.55 | 1232877.0 |
| ERAS | REDUCED | ERASCA INC | COM | 29479A108 | 174,956,000 | 3.28 | 9550000.0 |
| TARS | ADDED | TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 174,699,348 | 3.27 | 2775649.0 |
| ALNY | NEW | ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 144,494,400 | 2.71 | 480000.0 |
| INSM | ADDED | INSMED INC | COM PAR $.01 | 457669307 | 141,375,668 | 2.65 | 1325977.0 |
| MBX | NEW | MBX BIOSCIENCES INC | COM | 55287L101 | 138,442,428 | 2.59 | 2508015.0 |
| PCVX | REDUCED | VAXCYTE INC | COM | 92243G108 | 123,692,037 | 2.32 | 2127852.0 |
| - | VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 123,515,986 | 2.31 | 6723788.0 | |
| OLMA | ADDED | OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 108,468,906 | 2.03 | 8670576.0 |
| JBIO | NEW | JADE BIOSCIENCES INC | COM NEW | 008064206 | 63,491,539 | 1.19 | 2857405.0 |
| TYRA | REDUCED | TYRA BIOSCIENCES INC | COM | 90240B106 | 58,405,708 | 1.09 | 1828607.0 |
| ASMB | ADDED | ASSEMBLY BIOSCIENCES INC | COM NEW | 045396207 | 42,696,995 | 0.8 | 1553748.0 |
| EYPT | REDUCED | EYEPOINT INC | COM NEW | 30233G209 | 41,332,677 | 0.77 | 2890397.0 |
| - | ACHIEVE LIFE SCIENCE INC | COM | 004468500 | 32,335,620 | 0.61 | 4951856.0 | |
| VOR | UNCHANGED | VOR BIOPHARMA INC | COM NEW | 929033207 | 32,217,500 | 0.6 | 1750000.0 |
| MPLT | NEW | MAPLIGHT THERAPEUTICS INC | COM | 56565P103 | 24,580,936 | 0.46 | 685852.0 |
| KARD | NEW | KARDIGAN INC | COM | 485925101 | 21,465,000 | 0.4 | 900000.0 |
| LXEO | REDUCED | LEXEO THERAPEUTICS INC | COM | 52886X107 | 19,436,403 | 0.36 | 4175382.0 |
| EDIT | NEW | EDITAS MEDICINE INC | COM | 28106W103 | 18,100,665 | 0.34 | 5586625.0 |
| - | INVENTIVA SA | ADS | 46124U107 | 15,120,000 | 0.28 | 4000000.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 5,340,558,034 | 28 | 16.897196 | 0.302974 | 40.138649 |
| 2026-03-31 | 2026-05-15 | 4,894,261,608 | 35 | 11.785537 | 0.2102 | 31.718849 |
| 2025-12-31 | 2026-02-17 | 3,917,829,903 | 30 | 10.353568 | 0.163721 | 26.674043 |
| 2025-09-30 | 2025-11-14 | 3,516,196,926 | 36 | 7.227116 | 0.113805 | 19.677723 |
| 2025-03-31 | 2025-05-15 | 2,183,397,711 | 28 | 8.51153 | 0.141624 | 19.371103 |
| 2024-12-31 | 2025-02-14 | 2,874,091,779 | 28 | 9.111845 | 0.130135 | 23.488382 |