Ishara Investments LP
CIK 0002111609
Annualised vol
11.455746%
Beta
0.235896
HHI
385.218129
Top-10 weight
50.976119%
VaR 95%
1.027443%
VaR 99%
2.214791%
Max drawdown
22.498456%
Matched value
79.247464%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| ACAD | ADDED | 410,000 | 123,000 | 233.33% | 10,373,000 |
| XERS | ADDED | 1,230,000 | 1,025,000 | 20.0% | 9,741,600 |
| BMRN | ADDED | 143,500 | 82,000 | 75.0% | 8,211,070 |
| AGIO | NEW | 164,000 | - | - | 6,086,040 |
| INSM | NEW | 51,250 | - | - | 5,464,275 |
| ZNTL | REDUCED | 1,025,000 | 1,230,000 | -16.67% | 4,971,250 |
| PCVX | ADDED | 82,000 | 57,400 | 42.86% | 4,766,660 |
| ANNX | ADDED | 820,000 | 174,250 | 370.59% | 4,682,200 |
| TVTX | REDUCED | 82,000 | 110,700 | -25.93% | 4,658,420 |
| BBIO | NEW | 57,400 | - | - | 4,275,152 |
| AXSM | REDUCED | 16,400 | 41,000 | -60.0% | 4,014,228 |
| CTNM | ADDED | 205,000 | 142,000 | 44.37% | 3,359,950 |
| LXRX | ADDED | 1,271,000 | 902,000 | 40.91% | 3,050,400 |
| KURA | NEW | 276,750 | - | - | 3,035,948 |
| DBVT | ADDED | 184,500 | 102,500 | 80.0% | 3,025,800 |
| GMAB | ADDED | 102,500 | 82,000 | 25.0% | 2,815,675 |
| CYTK | NEW | 32,800 | - | - | 2,794,232 |
| MLYS | ADDED | 102,500 | 82,000 | 25.0% | 2,765,450 |
| SLN | REDUCED | 55,350 | 140,500 | -60.6% | 2,434,847 |
| NUVB | NEW | 369,000 | - | - | 2,095,920 |
| WVE | NEW | 328,000 | - | - | 1,905,680 |
| NKTR | NEW | 26,650 | - | - | 1,860,437 |
| ELVN | NEW | 32,800 | - | - | 1,664,600 |
| ALNY | UNCHANGED | 5,125 | 5,125 | 0.0% | 1,542,779 |
| BEAM | REDUCED | 41,000 | 57,400 | -28.57% | 1,407,120 |
| SION | ADDED | 123,000 | 49,200 | 150.0% | 1,350,540 |
| ORIC | ADDED | 123,000 | 102,500 | 20.0% | 1,332,090 |
| SPRY | NEW | 143,490 | - | - | 1,149,355 |
| MNPR | NEW | 12,300 | - | - | 1,138,857 |
| ERAS | NEW | 41,000 | - | - | 751,120 |
| VERA | REDUCED | 10,250 | 82,000 | -87.5% | 439,828 |
| IMTX | REDUCED | 30,750 | 153,750 | -80.0% | 311,498 |
| MREO | NEW | 768,750 | - | - | 244,232 |
| GOSS | UNCHANGED | 820,000 | 820,000 | 0.0% | 134,972 |
| VSTM | CLOSED OUT | 0 | 820,000 | -100.0% | 0 |
| ARDX | CLOSED OUT | 0 | 451,000 | -100.0% | 0 |
| MLTX | CLOSED OUT | 0 | 174,250 | -100.0% | 0 |
| EWTX | CLOSED OUT | 0 | 49,200 | -100.0% | 0 |
| IDYA | CLOSED OUT | 0 | 24,600 | -100.0% | 0 |
| PTCT | CLOSED OUT | 0 | 10,250 | -100.0% | 0 |
| LGND | CLOSED OUT | 0 | 8,200 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| ACAD | ADDED | ACADIA PHARMACEUTICALS INC | COM | 004225108 | 10,373,000 | 7.62 | 410000.0 |
| XERS | ADDED | XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 | 9,741,600 | 7.16 | 1230000.0 |
| BMRN | ADDED | BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 8,211,070 | 6.03 | 143500.0 |
| - | PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 | 7,549,515 | 5.55 | 22550.0 | |
| - | ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 6,844,950 | 5.03 | 205000.0 | |
| AGIO | NEW | AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 6,086,040 | 4.47 | 164000.0 |
| INSM | NEW | INSMED INC | COM PAR $.01 | 457669307 | 5,464,275 | 4.01 | 51250.0 |
| - | CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 5,369,770 | 3.95 | 143500.0 | |
| ZNTL | REDUCED | ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 | 4,971,250 | 3.65 | 1025000.0 |
| PCVX | ADDED | VAXCYTE INC | COM | 92243G108 | 4,766,660 | 3.5 | 82000.0 |
| ANNX | ADDED | ANNEXON INC | COM | 03589W102 | 4,682,200 | 3.44 | 820000.0 |
| TVTX | REDUCED | TRAVERE THERAPEUTICS INC | COM | 89422G107 | 4,658,420 | 3.42 | 82000.0 |
| - | TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260839 | 4,316,070 | 3.17 | 338250.0 | |
| BBIO | NEW | BRIDGEBIO PHARMA INC | COM | 10806X102 | 4,275,152 | 3.14 | 57400.0 |
| AXSM | REDUCED | AXSOME THERAPEUTICS INC. | COM | 05464T104 | 4,014,228 | 2.95 | 16400.0 |
| CTNM | ADDED | CONTINEUM THERAPEUTICS INC | CL A | 21217B100 | 3,359,950 | 2.47 | 205000.0 |
| LXRX | ADDED | LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 3,050,400 | 2.24 | 1271000.0 |
| KURA | NEW | KURA ONCOLOGY INC | COM | 50127T109 | 3,035,948 | 2.23 | 276750.0 |
| DBVT | ADDED | DBV TECHNOLOGIES S A | SPONSORED ADS | 23306J309 | 3,025,800 | 2.22 | 184500.0 |
| GMAB | ADDED | GENMAB A/S | SPONSORED ADS | 372303206 | 2,815,675 | 2.07 | 102500.0 |
| CYTK | NEW | CYTOKINETICS INC | COM NEW | 23282W605 | 2,794,232 | 2.05 | 32800.0 |
| MLYS | ADDED | MINERALYS THERAPEUTICS INC | COM | 603170101 | 2,765,450 | 2.03 | 102500.0 |
| SLN | REDUCED | SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 2,434,847 | 1.79 | 55350.0 |
| NUVB | NEW | NUVATION BIO INC | COM CL A | 67080N101 | 2,095,920 | 1.54 | 369000.0 |
| WVE | NEW | WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 1,905,680 | 1.4 | 328000.0 |
| NKTR | NEW | NEKTAR THERAPEUTICS | COM NEW | 640268306 | 1,860,437 | 1.37 | 26650.0 |
| - | SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 1,691,250 | 1.24 | 30750.0 | |
| ELVN | NEW | ENLIVEN THERAPEUTICS INC | COM | 29337E102 | 1,664,600 | 1.22 | 32800.0 |
| ALNY | UNCHANGED | ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 1,542,779 | 1.13 | 5125.0 |
| BEAM | REDUCED | BEAM THERAPEUTICS INC | COM | 07373V105 | 1,407,120 | 1.03 | 41000.0 |
| SION | ADDED | SIONNA THERAPEUTICS INC | COM | 829401108 | 1,350,540 | 0.99 | 123000.0 |
| ORIC | ADDED | ORIC PHARMACEUTICALS INC | COM | 68622P109 | 1,332,090 | 0.98 | 123000.0 |
| - | NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 1,250,541 | 0.92 | 36900.0 | |
| - | VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 1,221,956 | 0.9 | 2460.0 | |
| SPRY | NEW | ARS PHARMACEUTICALS INC | COM | 82835W108 | 1,149,355 | 0.84 | 143490.0 |
| MNPR | NEW | MONOPAR THERAPEUTICS INC | COM NEW | 61023L207 | 1,138,857 | 0.84 | 12300.0 |
| ERAS | NEW | ERASCA INC | COM | 29479A108 | 751,120 | 0.55 | 41000.0 |
| VERA | REDUCED | VERA THERAPEUTICS INC | CL A | 92337R101 | 439,828 | 0.32 | 10250.0 |
| IMTX | REDUCED | IMMATICS N.V | SHS | N44445109 | 311,498 | 0.23 | 30750.0 |
| MREO | NEW | MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 | 244,232 | 0.18 | 768750.0 |
| GOSS | UNCHANGED | GOSSAMER BIO INC | COM | 38341P102 | 134,972 | 0.1 | 820000.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 136,099,277 | 41 | 11.455746 | 0.235896 | 22.498456 |
| 2026-03-31 | 2026-05-15 | 105,625,159 | 37 | 9.840511 | 0.167829 | 15.561956 |
| 2025-12-31 | 2026-02-17 | 87,455,205 | 38 | 10.512253 | 0.200009 | 22.729094 |