← All institutions

Institutional Holdings

ANNX

Ownership Summary

Institutions Holding
257
Total Shares Held
170,231,778
Total Value Held
$869,923,035
Quarter
2025-12-31

Active Positions

Increased Positions
29
14,031,403 shares
Decreased Positions
16
1,690,586 shares
Held Positions
9
356,411 shares
New Positions
186
154,153,378 shares
Sold Out Positions
17
1,282,312 shares
Institution Shares Value Change % of Portfolio Reported
FMR LLC 10,222,470 $51,316,800 New position 2025-12-31
BlackRock, Inc. 8,960,434 $44,981,380 New position 2025-12-31
Redmile Group, LLC 10,050,644 $50,454,233 New position 2025-12-31
STATE STREET CORP 4,652,185 $23,353,969 New position 2025-12-31
BVF INC/IL 9,128,080 $45,822,962 New position 2025-12-31
Woodline Partners LP 4,000,074 $20,080,371 New position 2025-12-31
VANGUARD CAPITAL MANAGEMENT LLC 6,871,015 $39,233,496 New position 0.00% 2026-06-30
MAK CAPITAL ONE LLC 2,958,527 $14,851,806 New position 2025-12-31
GOLDMAN SACHS GROUP INC 1,768,745 $8,879,100 New position 2025-12-31
Siren, L.L.C. 4,458,646 $25,458,869 β–² +500,000 0.52% 2026-06-30
Bain Capital Life Sciences Investors, LLC 5,249,069 $26,350,326 New position 2025-12-31
Bellevue Group AG 5,157,290 $25,889,596 New position 2025-12-31
GEODE CAPITAL MANAGEMENT, LLC 2,902,896 $14,576,148 New position 2025-12-31
MPM BIOIMPACT LLC 3,544,354 $20,238,261 New position 1.23% 2026-06-30
AMERIPRISE FINANCIAL INC 4,348,782 $21,830,887 New position 2025-12-31
ADAGE CAPITAL PARTNERS GP, L.L.C. 5,500,000 $27,610,000 New position 2025-12-31
GREAT POINT PARTNERS LLC 3,500,000 $19,985,000 β–² +1,000,000 3.78% 2026-06-30
MORGAN STANLEY 2,856,143 $14,337,838 New position 2025-12-31
Palo Alto Investors LP 2,384,192 $11,968,644 New position 2025-12-31
BALYASNY ASSET MANAGEMENT L.P. 3,299,256 $16,562,265 New position 2025-12-31
Nuveen, LLC 2,915,324 $14,634,927 New position 2025-12-31
Qube Research & Technologies Ltd 2,381,479 $11,955,025 New position 2025-12-31
VANGUARD PORTFOLIO MANAGEMENT LLC 2,246,800 $12,829,228 New position 0.00% 2026-06-30
Opaleye Management Inc. 2,600,000 $13,052,000 New position 2025-12-31
Logos Global Management LP 1,500,000 $8,565,000 New position 0.37% 2026-06-30
DIMENSIONAL FUND ADVISORS LP 718,680 $3,607,910 New position 2025-12-31
Point72 Asset Management, L.P. 371,190 $1,863,374 New position 2025-12-31
NORTHERN TRUST CORP 792,000 $3,975,840 New position 2025-12-31
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,057,060 $5,306,441 New position 2025-12-31
Tetragon Partners GP Ltd 2,032,455 $10,202,924 New position 2025-12-31
Candriam S.C.A. 1,195,142 $6,817,695 New position 0.03% 2026-06-30
MILLENNIUM MANAGEMENT LLC 2,836,857 $14,241,022 New position 2025-12-31
VANGUARD FIDUCIARY TRUST CO 1,105,450 $6,312,120 New position 0.00% 2026-06-30
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 1,037,366 $5,923,360 β–² +133,998 0.00% 2026-06-30
JPMORGAN CHASE & CO 53,729 $269,719 New position 2025-12-31
WELLS FARGO & COMPANY/MN 573,748 $2,880,214 New position 2025-12-31
PANAGORA ASSET MANAGEMENT INC 967,926 $5,526,857 New position 0.02% 2026-06-30
CITADEL ADVISORS LLC 380,894 $1,912,088 New position 2025-12-31
KENNEDY CAPITAL MANAGEMENT LLC 639,902 $3,212,308 New position 2025-12-31
Ishara Investments LP 750,000 $3,765,000 New position 2025-12-31
Ensign Peak Advisors, Inc 800,516 $4,570,946 β–² +175,419 0.01% 2026-06-30
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 737,935 $4,213,609 New position 0.00% 2026-06-30
Y-Intercept (Hong Kong) Ltd 734,585 $4,194,480 β–Ό -585,328 0.08% 2026-06-30
Russell Investments Group, Ltd. 683,016 $3,428,739 New position 2025-12-31
AQR CAPITAL MANAGEMENT LLC 776,307 $3,897,061 New position 2025-12-31
SUSQUEHANNA INTERNATIONAL GROUP, LLP 354,308 $1,778,626 New position 2025-12-31
Parkman Healthcare Partners LLC 601,202 $3,018,034 New position 2025-12-31
UBS Group AG 377,104 $1,893,062 New position 2025-12-31
DEUTSCHE BANK AG TAUNUSANLAGE 12 D-60325 616,489 $3,520,153 β–² +54,308 0.00% 2026-06-30
BANK OF AMERICA CORP /DE/ 1,605,581 $8,060,016 β–² +311,279 2025-12-31
DEERFIELD MANAGEMENT COMPANY, L.P. 583,913 $2,931,243 New position 2025-12-31
SIRIOS CAPITAL MANAGEMENT L P 710,256 $3,565,485 New position 2025-12-31
Schonfeld Strategic Advisors LLC 522,846 $2,624,686 New position 2025-12-31
TWO SIGMA INVESTMENTS, LP 332,038 $1,666,831 New position 2025-12-31
Hennion & Walsh Asset Management, Inc. 507,050 $2,895,256 β–Ό -2,639 0.08% 2026-06-30
Bank of New York Mellon Corp 361,677 $1,815,619 New position 2025-12-31
Board of Trustees of The Leland Stanford Junior University 482,550 $2,422,401 New position 2025-12-31
RENAISSANCE TECHNOLOGIES LLC 802,600 $4,029,052 New position 2025-12-31
Ikarian Capital, LLC 230,244 $1,155,826 New position 2025-12-31
MOORE CAPITAL MANAGEMENT, LP 425,332 $2,428,646 New position 0.04% 2026-06-30
Trexquant Investment LP 409,667 $2,339,199 β–² +6,010 0.01% 2026-06-30
WELLINGTON MANAGEMENT GROUP LLP 398,077 $1,998,346 New position 2025-12-31
Susquehanna Portfolio Strategies, LLC 356,619 $1,790,227 New position 2025-12-31
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 642,038 $3,223,031 New position 2025-12-31
DIADEMA PARTNERS LP 659,100 $3,308,682 New position 2025-12-31
Invesco Ltd. 972,449 $4,881,694 New position 2025-12-31
SIMPLEX TRADING, LLC 10,268 $51,545 New position 2025-12-31
Engineers Gate Manager LP 319,057 $1,821,815 β–² +144,916 0.02% 2026-06-30
DAFNA Capital Management LLC 272,812 $1,369,516 New position 2025-12-31
Jump Financial, LLC 122,858 $616,747 New position 2025-12-31
STATE OF WISCONSIN INVESTMENT BOARD 286,375 $1,635,201 β–² +236,629 0.00% 2026-06-30
D. E. Shaw & Co., Inc. 1,046,221 $5,252,029 New position 2025-12-31
VOLORIDGE INVESTMENT MANAGEMENT, LLC 250,025 $1,427,643 β–Ό -212,043 0.01% 2026-06-30
Swiss National Bank 244,600 $1,396,666 β–² +8,600 0.00% 2026-06-30
CITIGROUP INC 23,640 $118,673 New position 2025-12-31
Cinctive Capital Management LP 358,986 $1,802,110 New position 2025-12-31
MARSHALL WACE, LLP 520,998 $2,615,410 New position 2025-12-31
RHUMBLINE ADVISERS 126,463 $634,834 New position 2025-12-31
SEI INVESTMENTS CO 58,259 $292,460 New position 2025-12-31
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 180,647 $1,031,495 β–² +50,000 0.00% 2026-06-30
Squarepoint Ops LLC 173,285 $989,457 β–² +105,329 0.00% 2026-06-30
Rafferty Asset Management, LLC 141,644 $711,053 New position 2025-12-31
OSAIC HOLDINGS, INC. 147,375 $739,822 New position 2025-12-31
ALLIANCEBERNSTEIN L.P. 140,740 $706,515 New position 2025-12-31
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 6,163 $30,938 New position 2025-12-31
VICTORY CAPITAL MANAGEMENT INC 14,757 $74,080 New position 2025-12-31
BOOTHBAY FUND MANAGEMENT, LLC 64,069 $321,626 New position 2025-12-31
IEQ CAPITAL, LLC 182,982 $918,569 New position 2025-12-31
J. Goldman & Co LP 993,795 $4,988,851 New position 2025-12-31
XTX Topco Ltd 243,313 $1,221,431 New position 2025-12-31
Vanguard Global Advisers, LLC 102,067 $582,803 New position 0.00% 2026-06-30
JANE STREET GROUP, LLC 577,036 $2,896,721 New position 2025-12-31
Quarry LP 75,000 $376,500 New position 2025-12-31
SCS Capital Management LLC 99,000 $565,290 Unchanged 0.01% 2026-06-30
Legal & General Group Plc 9,307 $46,721 New position 2025-12-31
GROUP ONE TRADING LLC 14,184 $71,204 New position 2025-12-31
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 54,763 $275,076 New position 2025-12-31
MetLife Investment Management, LLC 39,059 $196,076 New position 2025-12-31
J. Safra Sarasin Holding AG 90,487 $516,681 Unchanged 0.01% 2026-06-30
Zurcher Kantonalbank (Zurich Cantonalbank) 88,518 $505,438 β–² +34,651 0.00% 2026-06-30
CAPTRUST FINANCIAL ADVISORS 31,585 $158,557 New position 2025-12-31
PROFUND ADVISORS LLC 53,008 $266,100 New position 2025-12-31
VANGUARD ASSET MANAGEMENT, Ltd 79,486 $453,865 New position 0.00% 2026-06-30
DLD Asset Management, LP 75,000 $428,850 New position 0.03% 2026-06-30
DnB Asset Management AS 118,324 $593,986 New position 2025-12-31
Virtus Investment Advisers, LLC 53,527 $268,706 New position 2025-12-31
Jain Global LLC 64,719 $369,545 New position 0.00% 2026-06-30
China Universal Asset Management Co., Ltd. 36,084 $181,142 New position 2025-12-31
LOS ANGELES CAPITAL MANAGEMENT LLC 62,073 $354,437 Unchanged 0.00% 2026-06-30
DIVERSIFIED TRUST CO 61,797 $352,860 New position 0.01% 2026-06-30
Jupiter Topco LLC 59,100 $338,348 New position 0.00% 2026-06-30
VIRGINIA RETIREMENT SYSTEMS ET Al 54,300 $310,053 New position 0.00% 2026-06-30
WINTON GROUP Ltd 53,400 $268,068 New position 2025-12-31
JUPITER ASSET MANAGEMENT LTD 46,074 $263,083 New position 0.00% 2026-06-30
Creative Planning 24,004 $120,500 New position 2025-12-31
Police & Firemen's Retirement System of New Jersey 28,105 $141,087 New position 2025-12-31
Universal- Beteiligungs- und Servicegesellschaft mbH 44,706 $255,272 New position 0.00% 2026-06-30
JACOBS LEVY EQUITY MANAGEMENT, INC 683,879 $3,433,073 New position 2025-12-31
BARCLAYS PLC 289,963 $1,455,614 New position 2025-12-31
Persistent Asset Partners Ltd 93,657 $470,158 New position 2025-12-31
Allegheny Financial Group 42,900 $215,358 New position 2025-12-31
MANUFACTURERS LIFE INSURANCE COMPANY, THE 130,102 $655,094 New position 2025-12-31
DRW Securities, LLC 39,443 $225,219 β–Ό -15,041 0.01% 2026-06-30
State of New Jersey Common Pension Fund D 39,409 $225,025 β–Ό -1,344 0.00% 2026-06-30
BNP PARIBAS FINANCIAL MARKETS 61,572 $309,091 New position 2025-12-31
FIFTH THIRD BANCORP 38,640 $220,634 β–² +3,242 0.00% 2026-06-30
CANADA PENSION PLAN INVESTMENT BOARD 17,600 $88,352 New position 2025-12-31
NEW YORK STATE COMMON RETIREMENT FUND 29,568 $148,431 New position 2025-12-31
Vanguard Investments Australia, Ltd. 35,034 $200,044 New position 0.00% 2026-06-30
ARIZONA STATE RETIREMENT SYSTEM 33,630 $192,027 β–² +877 0.00% 2026-06-30
Blueshift Asset Management, LLC 33,338 $190,360 New position 0.04% 2026-06-30
PRELUDE CAPITAL MANAGEMENT, LLC 12,000 $60,240 New position 2025-12-31
VOYA INVESTMENT MANAGEMENT LLC 19,318 $96,976 New position 2025-12-31
Lido Advisors, LLC 34,952 $106,604 New position 2025-12-31
EntryPoint Capital, LLC 42,774 $214,725 New position 2025-12-31
INTECH INVESTMENT MANAGEMENT LLC 42,524 $213,470 New position 2025-12-31
Bridgefront Capital, LLC 28,528 $162,895 New position 0.04% 2026-06-30
Quadrature Capital Ltd 48,573 $243,836 New position 2025-12-31
KLP KAPITALFORVALTNING AS 26,300 $150,173 Unchanged 0.00% 2026-06-30
ProShare Advisors LLC 24,698 $123,984 New position 2025-12-31
Verdad Advisers, LP 25,300 $144,463 β–Ό -27,977 0.14% 2026-06-30
Brevan Howard Capital Management LP 123,753 $621,240 New position 2025-12-31
AlphaCentric Advisors LLC 24,872 $142,019 β–² +354 0.12% 2026-06-30
PRUDENTIAL FINANCIAL INC 24,850 $141,894 β–² +4,670 0.00% 2026-06-30
E Fund Management Co., Ltd. 24,433 $139,512 β–Ό -1,119 0.00% 2026-06-30
Crown Wealth Group, LLC 23,763 $135,687 New position 0.03% 2026-06-30
SBI Securities Co., Ltd. 25 $126 New position 2025-12-31
RAYMOND JAMES FINANCIAL INC 24,869 $124,842 New position 2025-12-31
STRS OHIO 21,200 $121,052 β–Ό -34,300 0.00% 2026-06-30
SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 21,010 $119,967 New position 0.00% 2026-06-30
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 10,016 $50,280 New position 2025-12-31
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 20,253 $117,467 β–Ό -1,679 0.00% 2026-06-30
Corient Private Wealth LP 19,704 $112,510 Unchanged 0.00% 2026-06-30
State of Wyoming 19,479 $111,225 New position 0.01% 2026-06-30
MERCER GLOBAL ADVISORS INC /ADV 10,386 $52,138 New position 2025-12-31
Coastal Bridge Advisors, LLC 17,000 $85,340 New position 2025-12-31
Pictet Asset Management Holding SA 16,701 $95,363 Unchanged 0.00% 2026-06-30
Mariner, LLC 31,335 $157,351 New position 2025-12-31
LPL Financial LLC 15,809 $90,269 β–² +2,595 0.00% 2026-06-30
Balefire, LLC 15,011 $85,713 β–² +11 0.01% 2026-06-30
XPONANCE LLC 14,865 $84,879 β–² +3,659 0.00% 2026-06-30
Forefront Analytics, LLC 13,226 $66,395 New position 2025-12-31
TEACHER RETIREMENT SYSTEM OF TEXAS 14,233 $81,270 β–Ό -866 0.00% 2026-06-30
Ameritas Investment Partners, Inc. 9,689 $48,639 New position 2025-12-31
Private Advisor Group, LLC 14,020 $80,054 New position 0.00% 2026-06-30
Cerity Partners LLC 14,801 $74,301 New position 2025-12-31
Integrated Wealth Concepts LLC 13,537 $77,292 β–² +3,305 0.00% 2026-06-30
BRIDGEWAY CAPITAL MANAGEMENT, LLC 137,800 $691,756 New position 2025-12-31
Tower Research Capital LLC (TRC) 1,966 $9,869 New position 2025-12-31
Vanguard Personalized Indexing Management, LLC 12,901 $64,763 New position 2025-12-31
Quantinno Capital Management LP 12,263 $70,022 New position 0.00% 2026-06-30
PRINCIPAL FINANCIAL GROUP INC 11,876 $67,812 New position 0.00% 2026-06-30
Merit Financial Group, LLC 11,103 $63,398 β–² +358 0.00% 2026-06-30
FOX RUN MANAGEMENT, L.L.C. 10,920 $62,353 β–Ό -6,758 0.01% 2026-06-30
NISA INVESTMENT ADVISORS, LLC 10,779 $61,548 β–² +3,366 0.00% 2026-06-30
Harbor Advisors LLC 10,000 $50,200 New position 2025-12-31
Shay Capital LLC 10,000 $57,100 Unchanged 0.00% 2026-06-30
Arax Advisory Partners 19 $95 New position 2025-12-31
Mirae Asset Global Investments Co., Ltd. 14,066 $70,612 New position 2025-12-31
Geneos Wealth Management Inc. 6,000 $30,120 New position 2025-12-31
ROYAL BANK OF CANADA 2,855 $15,000 New position 2025-12-31
JONES FINANCIAL COMPANIES LLLP 2,987 $14,995 New position 2025-12-31
GF FUND MANAGEMENT CO. LTD. 2,843 $14,272 New position 2025-12-31
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 2,024 $11,557 β–Ό -343 0.00% 2026-06-30
Larson Financial Group LLC 2,000 $10,040 New position 2025-12-31
Quantbot Technologies LP 1,562 $8,919 β–² +1,254 0.00% 2026-06-30
PNC FINANCIAL SERVICES GROUP, INC. 1,132 $5,683 New position 2025-12-31
Burnham & Co LLC 1,000 $5,710 New position 0.00% 2026-06-30
Allworth Financial LP 416 $2,089 New position 2025-12-31
Rockefeller Capital Management L.P. 334 $1,677 New position 2025-12-31
Farther Finance Advisors, LLC 738 $4,185 β–Ό -627 0.00% 2026-06-30
Essential Partners LLC 674 $3,849 β–Ό -418 0.00% 2026-06-30
ACADIAN ASSET MANAGEMENT LLC 861,245 $4,321 New position 2025-12-31
GAMMA Investing LLC 570 $3,255 β–² +254 0.00% 2026-06-30
IFP Advisors, Inc 547 $2,746 β–² +197 2025-12-31
EverSource Wealth Advisors, LLC 539 $2,706 New position 2025-12-31
Sterling Capital Management LLC 5,967 $29,954 New position 2025-12-31
Caitong International Asset Management Co., Ltd 16,415 $82,403 New position 2025-12-31
Fortitude Family Office, LLC 483 $2,758 β–² +396 0.00% 2026-06-30
Optiver Holding B.V. 530 $2,661 New position 2025-12-31
HighMark Wealth Management LLC 300 $1,506 New position 2025-12-31
True Wealth Design, LLC 283 $1,616 β–Ό -39 0.00% 2026-06-30
Physician Wealth Advisors, Inc. 269 $1,351 New position 2025-12-31
ROTHSCHILD INVESTMENT LLC 236 $1,185 New position 2025-12-31
Global Retirement Partners, LLC 181 $1,034 New position 0.00% 2026-06-30
PRICE T ROWE ASSOCIATES INC /MD/ 445,074 $2,235 New position 2025-12-31
GSA CAPITAL PARTNERS LLP 104,378 $596 β–² +72,684 0.04% 2026-06-30
NATIONAL BANK OF CANADA /FI/ 67 $383 New position 0.00% 2026-06-30
SG Americas Securities, LLC 42,823 $245 New position 0.00% 2026-06-30
CANADA LIFE ASSURANCE Co 21,646 $124 Unchanged 0.00% 2026-06-30
SJS Investment Consulting Inc. 20 $115 β–² +3 0.00% 2026-06-30
Stone House Investment Management, LLC 16 $91 β–Ό -4 0.00% 2026-06-30
Clearstead Advisors, LLC 15 $86 New position 0.00% 2026-06-30
MOUNT VERNON ASSOCIATES INC /MD/ 10,500 $60 Unchanged 0.04% 2026-06-30
Cambridge Investment Research Advisors, Inc. 10,700 $54 New position 2025-12-31
Pacer Advisors, Inc. 2,894 $17 New position 0.00% 2026-06-30
Silver Grove Financial Group, Inc. 1 $6 New position 0.00% 2026-06-30
Longaeva Partners L.P. 3,100,000 $15,562,000 New position 2025-12-31
SILVERARC CAPITAL MANAGEMENT, LLC 0 $0 Sold out 2026-06-30
Rosalind Advisors, Inc. 0 $0 Sold out 2026-06-30
ALGERT GLOBAL LLC 0 $0 Sold out 2026-06-30
Man Group plc 0 $0 Sold out 2026-06-30
Connor, Clark & Lunn Investment Management Ltd. 0 $0 Sold out 2026-06-30
POLEN CAPITAL MANAGEMENT LLC 0 $0 Sold out 2026-06-30
AXQ CAPITAL, LP 29,108 $146,122 New position 2025-12-31
ADAR1 Capital Management, LLC 96,000 $481,920 New position 2025-12-31
BIT Capital GmbH 0 $0 Sold out 2026-06-30
MIRABELLA FINANCIAL SERVICES LLP 0 $0 Sold out 2026-06-30
Virtu Financial LLC 0 $0 Sold out 2026-06-30
TD ASSET MANAGEMENT INC 46,848 $235,177 New position 2025-12-31
Scientech Research LLC 17,216 $86,424 New position 2025-12-31
Vontobel Holding Ltd. 0 $0 Sold out 2026-06-30
Magnetar Financial LLC 0 $0 Sold out 2026-06-30
AMERICAN CENTURY COMPANIES INC 251,158 $1,260,813 New position 2025-12-31
nVerses Capital, LLC 0 $0 Sold out 2026-06-30
Abel Hall, LLC 0 $0 Sold out 2026-06-30
MAI Capital Management 63 $317 New position 2025-12-31
FEDERATED HERMES, INC. 753 $3,780 New position 2025-12-31
Root Financial Partners, LLC 0 $0 Sold out 2026-06-30
US BANCORP DE U.S. BANCORP 0 $0 Sold out 2026-06-30
Advisory Services Network, LLC 0 $0 Sold out 2026-06-30
JPL Wealth Management, LLC 0 $0 Sold out 2026-06-30
VANGUARD GROUP INC 7,753,387 $38,922,003 New position 2025-12-31
SPHERA FUNDS MANAGEMENT LTD. 1,316,212 $6,607,384 New position 2025-12-31
DEUTSCHE BANK AG\ 560,744 $2,814,935 New position 2025-12-31
Caption Management, LLC 489,191 $2,455,739 New position 2025-12-31
SummitTX Capital, L.P. 438,497 $2,201,255 New position 2025-12-31
CITIZENS FINANCIAL GROUP INC/RI 40,000 $200,800 New position 2025-12-31
Pale Fire Capital SE 38,600 $193,772 New position 2025-12-31
Landing Point Financial Group, LLC 34,900 $175,198 New position 2025-12-31
COMERICA BANK 32,357 $162,432 New position 2025-12-31
Corient Private Wealth LLC 19,693 $98,859 New position 2025-12-31
Sunbelt Securities, Inc. 110 $552 New position 2025-12-31
CWM, LLC 60,594 $304 New position 2025-12-31
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 4 $20 New position 2025-12-31
AMALGAMATED BANK 3,144 $16 New position 2025-12-31
Daiwa Securities Group Inc. 352 $2 New position 2025-12-31