GREAT POINT PARTNERS LLC
CIK 0001281446
Annualised vol
10.914607%
Beta
0.091306
HHI
400.30678
Top-10 weight
51.635189%
VaR 95%
1.004509%
VaR 99%
2.204306%
Max drawdown
33.0272%
Matched value
73.284876%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| VOR | REDUCED | 1,700,000 | 1,750,000 | -2.86% | 31,297,000 |
| IBRX | UNCHANGED | 3,000,800 | 3,000,800 | 0.0% | 26,272,004 |
| VERA | ADDED | 600,836 | 199,348 | 201.4% | 25,781,873 |
| ZURA | UNCHANGED | 4,215,930 | 4,215,930 | 0.0% | 24,873,987 |
| ALMS | UNCHANGED | 856,061 | 856,061 | 0.0% | 24,089,557 |
| SLGL | UNCHANGED | 274,363 | 274,363 | 0.0% | 20,341,273 |
| DFTX | NEW | 425,000 | - | - | 19,992,000 |
| ANNX | ADDED | 3,500,000 | 2,500,000 | 40.0% | 19,985,000 |
| ORKA | UNCHANGED | 183,330 | 183,330 | 0.0% | 17,447,516 |
| MLTX | ADDED | 855,813 | 500,000 | 71.16% | 16,662,679 |
| SGMT | NEW | 2,029,933 | - | - | 15,691,382 |
| CTNM | ADDED | 921,481 | 800,198 | 15.16% | 15,103,074 |
| IMMX | ADDED | 1,277,642 | 350,000 | 265.04% | 13,172,489 |
| CLYM | REDUCED | 1,000,000 | 1,334,130 | -25.04% | 13,040,000 |
| AMLX | REDUCED | 700,000 | 1,750,000 | -60.0% | 12,572,000 |
| NKTR | REDUCED | 175,000 | 316,453 | -44.7% | 12,216,750 |
| NGNE | REDUCED | 352,180 | 500,000 | -29.56% | 11,076,061 |
| LBRX | ADDED | 317,221 | 300,000 | 5.74% | 10,295,408 |
| IRD | ADDED | 1,970,187 | 324,340 | 507.44% | 8,097,469 |
| EPRX | UNCHANGED | 1,200,000 | 1,200,000 | 0.0% | 7,932,000 |
| DRUG | REDUCED | 109,603 | 220,000 | -50.18% | 7,694,131 |
| RLMD | UNCHANGED | 842,106 | 842,106 | 0.0% | 5,827,374 |
| JATT | NEW | 500,000 | - | - | 5,680,000 |
| CGEM | UNCHANGED | 300,000 | 300,000 | 0.0% | 5,463,000 |
| ALT | NEW | 1,741,232 | - | - | 5,293,345 |
| AMAN | NEW | 500,000 | - | - | 5,080,000 |
| RZLT | UNCHANGED | 951,809 | 951,809 | 0.0% | 4,949,407 |
| SLN | REDUCED | 450,000 | 1,020,489 | -55.9% | 4,941,000 |
| PALI | REDUCED | 2,284,819 | 3,405,757 | -32.91% | 4,775,272 |
| EVMN | UNCHANGED | 325,000 | 325,000 | 0.0% | 4,319,250 |
| SCYX | REDUCED | 944,292 | 7,554,347 | -87.5% | 3,843,268 |
| GALT | UNCHANGED | 800,000 | 800,000 | 0.0% | 3,712,000 |
| ELVN | NEW | 70,000 | - | - | 3,552,500 |
| HUMA | UNCHANGED | 3,750,000 | 3,750,000 | 0.0% | 2,926,500 |
| RNTX | NEW | 2,575,000 | - | - | 2,678,000 |
| DBVT | NEW | 156,906 | - | - | 2,573,258 |
| AVXL | UNCHANGED | 521,300 | 521,300 | 0.0% | 1,350,167 |
| PMN | REDUCED | 86,150 | 371,402 | -76.8% | 1,133,734 |
| CNTX | CLOSED OUT | 0 | 2,238,496 | -100.0% | 0 |
| CMPX | CLOSED OUT | 0 | 1,350,000 | -100.0% | 0 |
| JBIO | CLOSED OUT | 0 | 964,462 | -100.0% | 0 |
| UNCY | CLOSED OUT | 0 | 796,558 | -100.0% | 0 |
| IMVT | CLOSED OUT | 0 | 545,625 | -100.0% | 0 |
| ZBIO | CLOSED OUT | 0 | 524,066 | -100.0% | 0 |
| TENX | CLOSED OUT | 0 | 327,307 | -100.0% | 0 |
| AVTX | CLOSED OUT | 0 | 124,666 | -100.0% | 0 |
| PHVS | CLOSED OUT | 0 | 82,800 | -100.0% | 0 |
| ALKS | CLOSED OUT | 0 | 50,000 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| - | ABIVAX SA | SPONSORED ADS | 00370M103 | 53,304,000 | 10.07 | 400000.0 | |
| VOR | REDUCED | VOR BIOPHARMA INC | COM NEW | 929033207 | 31,297,000 | 5.91 | 1700000.0 |
| - | ABIVAX SA | SPONSORED ADS | 00370M103 | 27,226,884 | 5.15 | 204314.0 | |
| IBRX | UNCHANGED | IMMUNITYBIO INC | COM | 45256X103 | 26,272,004 | 4.97 | 3000800.0 |
| VERA | ADDED | VERA THERAPEUTICS INC | CL A | 92337R101 | 25,781,873 | 4.87 | 600836.0 |
| ZURA | UNCHANGED | ZURA BIO LTD | CLASS A ORD SHS | G9TY5A101 | 24,873,987 | 4.7 | 4215930.0 |
| ALMS | UNCHANGED | ALUMIS INC | COM | 022307102 | 24,089,557 | 4.55 | 856061.0 |
| SLGL | UNCHANGED | SOL-GEL TECHNOLOGIES LTD | SHS NEW | M8694L137 | 20,341,273 | 3.84 | 274363.0 |
| - | ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 20,034,000 | 3.79 | 600000.0 | |
| DFTX | NEW | DEFINIUM THERAPEUTICS INC | COM SHS | 24477V105 | 19,992,000 | 3.78 | 425000.0 |
| ANNX | ADDED | ANNEXON INC | COM | 03589W102 | 19,985,000 | 3.78 | 3500000.0 |
| ORKA | UNCHANGED | ORUKA THERAPEUTICS INC | COM | 687604108 | 17,447,516 | 3.3 | 183330.0 |
| MLTX | ADDED | MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 16,662,679 | 3.15 | 855813.0 |
| SGMT | NEW | SAGIMET BIOSCIENCES INC | COM SER A | 786700104 | 15,691,382 | 2.97 | 2029933.0 |
| CTNM | ADDED | CONTINEUM THERAPEUTICS INC | CL A | 21217B100 | 15,103,074 | 2.85 | 921481.0 |
| IMMX | ADDED | IMMIX BIOPHARMA INC | COM | 45258H106 | 13,172,489 | 2.49 | 1277642.0 |
| CLYM | REDUCED | CLIMB BIO INC | COM | 28658R106 | 13,040,000 | 2.46 | 1000000.0 |
| AMLX | REDUCED | AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 12,572,000 | 2.38 | 700000.0 |
| NKTR | REDUCED | NEKTAR THERAPEUTICS | COM NEW | 640268306 | 12,216,750 | 2.31 | 175000.0 |
| NGNE | REDUCED | NEUROGENE INC | COM | 64135M105 | 11,076,061 | 2.09 | 352180.0 |
| LBRX | ADDED | LB PHARMACEUTICALS INC | COM SHS | 50180M108 | 10,295,408 | 1.95 | 317221.0 |
| IRD | ADDED | OPUS GENETICS INC | COM | 67577R102 | 8,097,469 | 1.53 | 1970187.0 |
| EPRX | UNCHANGED | EUPRAXIA PHARMACEUTICALS INC | COM | 29842P105 | 7,932,000 | 1.5 | 1200000.0 |
| DRUG | REDUCED | BRIGHT MINDS BIOSCIENCES INC | COM NEW | 10919W405 | 7,694,131 | 1.45 | 109603.0 |
| - | INFLARX NV | COM | N44821101 | 6,824,288 | 1.29 | 3046557.0 | |
| RLMD | UNCHANGED | RELMADA THERAPEUTICS INC | COM | 75955J402 | 5,827,374 | 1.1 | 842106.0 |
| JATT | NEW | JATT II ACQUISITION CORP | ORD SHS | G50765109 | 5,680,000 | 1.07 | 500000.0 |
| CGEM | UNCHANGED | CULLINAN THERAPEUTICS INC | COM | 230031106 | 5,463,000 | 1.03 | 300000.0 |
| ALT | NEW | ALTIMMUNE INC | COM NEW | 02155H200 | 5,293,345 | 1.0 | 1741232.0 |
| AMAN | NEW | AMANAT ACQUISITION CORP | CL A ORD | G0375M101 | 5,080,000 | 0.96 | 500000.0 |
| RZLT | UNCHANGED | REZOLUTE INC | COM NEW | 76200L309 | 4,949,407 | 0.94 | 951809.0 |
| SLN | REDUCED | SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 4,941,000 | 0.93 | 450000.0 |
| PALI | REDUCED | PALISADE BIO INC | COM | 696389402 | 4,775,272 | 0.9 | 2284819.0 |
| EVMN | UNCHANGED | EVOMMUNE INC | COM SHS | 30054Y107 | 4,319,250 | 0.82 | 325000.0 |
| SCYX | REDUCED | SCYNEXIS INC | COM | 811292309 | 3,843,268 | 0.73 | 944292.0 |
| GALT | UNCHANGED | GALECTIN THERAPEUTICS INC | COM NEW | 363225202 | 3,712,000 | 0.7 | 800000.0 |
| ELVN | NEW | ENLIVEN THERAPEUTICS INC | COM | 29337E102 | 3,552,500 | 0.67 | 70000.0 |
| HUMA | UNCHANGED | HUMACYTE INC | COM | 44486Q103 | 2,926,500 | 0.55 | 3750000.0 |
| RNTX | NEW | REIN THERAPEUTICS INC | COM NEW | 00887A204 | 2,678,000 | 0.51 | 2575000.0 |
| DBVT | NEW | DBV TECHNOLOGIES S A | SPONSORED ADS | 23306J309 | 2,573,258 | 0.49 | 156906.0 |
| AVXL | UNCHANGED | ANAVEX LIFE SCIENCES CORP | COM NEW | 032797300 | 1,350,167 | 0.26 | 521300.0 |
| PMN | REDUCED | PROMIS NEUROSCIENCES INC | COM SHS | 74346M505 | 1,133,734 | 0.21 | 86150.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 529,120,900 | 42 | 10.914607 | 0.091306 | 33.0272 |
| 2026-03-31 | 2026-05-15 | 435,118,234 | 42 | 12.099484 | 0.095891 | 36.320661 |
| 2025-12-31 | 2026-02-17 | 308,414,328 | 29 | 9.82618 | 0.081703 | 30.909034 |
| 2025-09-30 | 2025-11-14 | 242,495,757 | 30 | 10.845256 | 0.109101 | 32.729868 |
| 2025-03-31 | 2025-05-15 | 188,796,269 | 32 | 8.433098 | 0.107108 | 26.443576 |
| 2024-12-31 | 2025-02-14 | 212,199,809 | 26 | 8.869401 | 0.125712 | 34.255962 |