← All institutions

Institutional Holdings

LXRX

Ownership Summary

Institutions Holding
195
Total Shares Held
279,643,018
Total Value Held
$343,425,877
Quarter
2025-12-31

Active Positions

Increased Positions
8
1,393,847 shares
Decreased Positions
6
555,867 shares
Held Positions
12
826,586 shares
New Positions
151
276,866,718 shares
Sold Out Positions
18
2,111,441 shares
Institution Shares Value Change % of Portfolio Reported
Artal Group S.A. 136,180,481 $156,607,553 New position 2025-12-31
FMR LLC 37,834,207 $43,509,338 New position 2025-12-31
Siren, L.L.C. 38,918,903 $44,756,738 New position 2025-12-31
Sessa Capital IM, L.P. 3,000,000 $3,450,000 New position 2025-12-31
BlackRock, Inc. 3,192,448 $3,671,316 New position 2025-12-31
VANGUARD CAPITAL MANAGEMENT LLC 9,901,208 $23,762,899 New position 0.00% 2026-06-30
Point72 Asset Management, L.P. 284,025 $326,629 New position 2025-12-31
GEODE CAPITAL MANAGEMENT, LLC 2,500,022 $2,876,410 New position 2025-12-31
STATE STREET CORP 884,738 $1,017,449 New position 2025-12-31
VANGUARD PORTFOLIO MANAGEMENT LLC 2,357,749 $5,658,598 New position 0.00% 2026-06-30
CITADEL ADVISORS LLC 2,269,075 $2,609,436 New position 2025-12-31
NORTHERN TRUST CORP 412,164 $473,989 New position 2025-12-31
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,055,123 $1,213,391 New position 2025-12-31
VANGUARD FIDUCIARY TRUST CO 1,634,571 $3,922,970 New position 0.00% 2026-06-30
SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,543,242 $1,774,729 New position 2025-12-31
Ishara Investments LP 880,000 $1,012,000 New position 2025-12-31
MILLENNIUM MANAGEMENT LLC 4,821,733 $5,544,993 New position 2025-12-31
RENAISSANCE TECHNOLOGIES LLC 263,254 $302,742 New position 2025-12-31
MACKENZIE FINANCIAL CORP 963,354 $2,312,050 ▲ +190,677 0.00% 2026-06-30
ADAR1 Capital Management, LLC 750,000 $1,800,000 Unchanged 0.08% 2026-06-30
UBS Group AG 3,007,237 $3,458,322 New position 2025-12-31
GROUP ONE TRADING LLC 224,308 $257,954 New position 2025-12-31
TWO SIGMA INVESTMENTS, LP 637,308 $732,904 New position 2025-12-31
Nuveen, LLC 586,664 $1,407,994 New position 0.00% 2026-06-30
JANE STREET GROUP, LLC 1,828,404 $2,102,665 New position 2025-12-31
Bank of New York Mellon Corp 19,124 $21,992 New position 2025-12-31
Invesco Ltd. 594,883 $684,115 New position 2025-12-31
GOLDMAN SACHS GROUP INC 921,204 $1,059,385 New position 2025-12-31
Compagnie Lombard Odier SCmA 480,000 $1,152,000 ▼ -30,000 0.01% 2026-06-30
BANK OF AMERICA CORP /DE/ 102,097 $117,412 ▲ +44,293 2025-12-31
BARCLAYS PLC 194,743 $223,954 New position 2025-12-31
XTX Topco Ltd 96,090 $110,504 New position 2025-12-31
CANADA PENSION PLAN INVESTMENT BOARD 257,900 $618,960 New position 0.00% 2026-06-30
RHUMBLINE ADVISERS 0 $2 Sold out 2025-12-31
DEUTSCHE BANK AG TAUNUSANLAGE 12 D-60325 247,528 $594,068 New position 0.00% 2026-06-30
WELLS FARGO & COMPANY/MN 1 $1 New position 2025-12-31
WELLINGTON MANAGEMENT GROUP LLP 179,700 $431,280 New position 0.00% 2026-06-30
CITIGROUP INC 91,670 $105,421 New position 2025-12-31
Virtus Investment Advisers, LLC 170,415 $408,996 New position 0.10% 2026-06-30
Headlands Technologies LLC 136,113 $156,530 New position 2025-12-31
Ikarian Capital, LLC 164,674 $189,376 New position 2025-12-31
Quarry LP 88,000 $101,200 New position 2025-12-31
MetLife Investment Management, LLC 146,410 $351,384 New position 0.00% 2026-06-30
MORGAN STANLEY 193,035 $221,990 New position 2025-12-31
PANAGORA ASSET MANAGEMENT INC 132,042 $316,901 New position 0.00% 2026-06-30
JPMORGAN CHASE & CO 109,839 $289,975 New position 0.00% 2026-06-30
State of Wyoming 60,571 $69,657 New position 2025-12-31
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 114,114 $273,874 New position 0.00% 2026-06-30
Cornerstone Investment Partners, LLC 113,739 $272,974 New position 0.01% 2026-06-30
Cerity Partners LLC 144,944 $166,686 New position 2025-12-31
ALGERT GLOBAL LLC 92,150 $221,160 New position 0.00% 2026-06-30
BANK OF NOVA SCOTIA 86,607 $207,857 ▲ +12,900 0.00% 2026-06-30
LPL Financial LLC 87,057 $100,116 New position 2025-12-31
SIMPLEX TRADING, LLC 14,758 $16,971 New position 2025-12-31
Vanguard Global Advisers, LLC 77,946 $187,070 New position 0.00% 2026-06-30
AQR CAPITAL MANAGEMENT LLC 144,800 $166,520 New position 2025-12-31
Police & Firemen's Retirement System of New Jersey 73,402 $176,165 New position 0.00% 2026-06-30
PRUDENTIAL FINANCIAL INC 33,800 $38,870 New position 2025-12-31
MANUFACTURERS LIFE INSURANCE COMPANY, THE 69,747 $167,393 New position 0.00% 2026-06-30
NEW YORK STATE COMMON RETIREMENT FUND 68,400 $164,160 New position 0.00% 2026-06-30
TWO SIGMA SECURITIES, LLC 114,632 $131,827 New position 2025-12-31
SEI INVESTMENTS CO 63,937 $153,449 New position 0.00% 2026-06-30
Straight Path Wealth Management 62,666 $72,066 New position 2025-12-31
R Squared Ltd 46,579 $53,566 New position 2025-12-31
Vanguard Personalized Indexing Management, LLC 66,567 $76,552 New position 2025-12-31
Fortis Group Advisors, LLC 50,000 $58,000 New position 2025-12-31
Schonfeld Strategic Advisors LLC 13,108 $15,072 New position 2025-12-31
SCOTIA CAPITAL INC. 48,871 $117,291 ▼ -110,960 0.00% 2026-06-30
PROFUND ADVISORS LLC 48,586 $116,606 New position 0.00% 2026-06-30
VOYA INVESTMENT MANAGEMENT LLC 47,771 $114,650 New position 0.00% 2026-06-30
AXQ CAPITAL, LP 45,727 $109,745 ▲ +25,577 0.01% 2026-06-30
BOOTHBAY FUND MANAGEMENT, LLC 44,315 $50,962 New position 2025-12-31
ALLIANCEBERNSTEIN L.P. 67,800 $105,768 New position 0.00% 2026-06-30
WINTON GROUP Ltd 43,200 $103,680 ▲ +17,700 0.00% 2026-06-30
INTECH INVESTMENT MANAGEMENT LLC 42,491 $101,978 New position 0.00% 2026-06-30
LMR Partners LLP 41,091 $98,618 ▲ +17,786 0.00% 2026-06-30
BANK OF MONTREAL /CAN/ 70,000 $80,500 New position 2025-12-31
BNP PARIBAS FINANCIAL MARKETS 11 $13 New position 2025-12-31
Rafferty Asset Management, LLC 34,090 $81,816 New position 0.00% 2026-06-30
ProShare Advisors LLC 32,588 $78,212 New position 0.00% 2026-06-30
Leonteq Securities AG 30,000 $34,500 New position 2025-12-31
Pathstone Holdings, LLC 29,969 $34,464 New position 2025-12-31
PINNACLE ASSOCIATES LTD 29,015 $33,367 New position 2025-12-31
VICTORY CAPITAL MANAGEMENT INC 21,191 $24,370 New position 2025-12-31
Legal & General Group Plc 24,185 $58,044 New position 0.00% 2026-06-30
XPONANCE LLC 23,763 $57,031 New position 0.00% 2026-06-30
Graham Capital Management, L.P. 109,900 $126,385 New position 2025-12-31
Ameritas Investment Partners, Inc. 22,986 $55,166 New position 0.00% 2026-06-30
D. E. Shaw & Co., Inc. 22,200 $53,280 New position 0.00% 2026-06-30
Quadrature Capital Ltd 18,414 $21,176 New position 2025-12-31
TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC 20,000 $48,000 Unchanged 0.00% 2026-06-30
DIKER MANAGEMENT LLC 20,000 $48,000 Unchanged 0.04% 2026-06-30
Invera Wealth Advisors, LLC 20,000 $48,000 Unchanged 0.03% 2026-06-30
Russell Investments Group, Ltd. 19,902 $47,764 New position 0.00% 2026-06-30
Tower Research Capital LLC (TRC) 29,093 $33,457 New position 2025-12-31
SBI Securities Co., Ltd. 3,018 $3,471 New position 2025-12-31
PRINCIPAL FINANCIAL GROUP INC 19,034 $45,682 New position 0.00% 2026-06-30
CREDIT AGRICOLE S A 18,975 $21,821 New position 2025-12-31
CAPTRUST FINANCIAL ADVISORS 11,735 $13,495 New position 2025-12-31
Callan Family Office, LLC 14,090 $16,204 New position 2025-12-31
TRUIST FINANCIAL CORP 14,000 $16,100 New position 2025-12-31
CIBC Bancorp USA Inc. 13,740 $32,976 ▼ -1,786,260 0.00% 2026-06-30
Gotham Asset Management, LLC 13,627 $32,705 New position 0.00% 2026-06-30
CIBC Asset Management Inc 39,520 $45,448 New position 2025-12-31
ROYAL BANK OF CANADA 6,768 $7,000 New position 2025-12-31
HBK Sorce Advisory LLC 11,786 $14,497 New position 2025-12-31
Squarepoint Ops LLC 60,472 $69,543 New position 2025-12-31
Apollon Wealth Management, LLC 11,378 $27,307 New position 0.00% 2026-06-30
Mariner, LLC 11,239 $26,974 ▲ +167 0.00% 2026-06-30
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 12,139 $26,949 ▼ -249 0.00% 2026-06-30
Perennial Investment Advisors, LLC 10,990 $12,639 New position 2025-12-31
Cetera Investment Advisers 14,188 $16,316 New position 2025-12-31
NBT BANK, N.A. 10,000 $24,000 Unchanged 0.00% 2026-06-30
Berger Financial Group, Inc 10,000 $11,500 New position 2025-12-31
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 3,427 $8,225 New position 0.00% 2026-06-30
NISA INVESTMENT ADVISORS, LLC 2,592 $6,221 Unchanged 0.00% 2026-06-30
Integrated Wealth Concepts LLC 2,077 $4,985 New position 0.00% 2026-06-30
PNC FINANCIAL SERVICES GROUP, INC. 1,461 $1,679 New position 2025-12-31
Physician Wealth Advisors, Inc. 1,412 $1,624 New position 2025-12-31
Rialto Wealth Management, LLC 1,313 $3,152 Unchanged 0.00% 2026-06-30
Global Retirement Partners, LLC 1,000 $1,150 New position 2025-12-31
Cassaday & Co Wealth Management LLC 1,000 $2,400 Unchanged 0.00% 2026-06-30
MassMutual Private Wealth & Trust, FSB 957 $2,297 New position 0.00% 2026-06-30
Sterling Capital Management LLC 874 $2,098 New position 0.00% 2026-06-30
Aster Capital Management (DIFC) Ltd 743 $1,783 New position 0.00% 2026-06-30
Fortitude Family Office, LLC 706 $1,694 Unchanged 0.00% 2026-06-30
ACADIAN ASSET MANAGEMENT LLC 640,130 $732 New position 2025-12-31
Basecamp Wealth Advisors LLC 691 $1,658 Unchanged 0.00% 2026-06-30
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 4,777 $6,392 New position 2025-12-31
Steward Partners Investment Advisory, LLC 500 $575 New position 2025-12-31
GSA CAPITAL PARTNERS LLP 996,235 $1,146 New position 2025-12-31
JONES FINANCIAL COMPANIES LLLP 1,106 $1,272 New position 2025-12-31
Rockefeller Capital Management L.P. 335 $385 New position 2025-12-31
Allworth Financial LP 263 $632 New position 0.00% 2026-06-30
Parallel Advisors, LLC 247 $593 Unchanged 0.00% 2026-06-30
PRICE T ROWE ASSOCIATES INC /MD/ 204,391 $491 New position 0.00% 2026-06-30
OSAIC HOLDINGS, INC. 642 $738 New position 2025-12-31
Caitong International Asset Management Co., Ltd 2,484 $2,857 New position 2025-12-31
SYNTAX RESEARCH, INC. 142 $164 New position 2025-12-31
Clearstead Advisors, LLC 100 $240 New position 0.00% 2026-06-30
Larson Financial Group LLC 100 $115 New position 2025-12-31
Arax Advisory Partners 41 $47 New position 2025-12-31
HM PAYSON & CO 37 $89 Unchanged 0.00% 2026-06-30
WEDBUSH SECURITIES INC 40,850 $47 New position 2025-12-31
Blume Capital Management, Inc. 5 $12 New position 0.00% 2026-06-30
Farther Finance Advisors, LLC 2 $5 ▼ -253 0.00% 2026-06-30
Avion Wealth 1,115 $2 ▼ -218 0.00% 2026-06-30
Covestor Ltd 81 $0 New position 2025-12-31
Hennion & Walsh Asset Management, Inc. 0 $0 Sold out 2026-06-30
TANG CAPITAL MANAGEMENT LLC 0 $0 Sold out 2026-06-30
Catalyst Funds Management Pty Ltd 40,300 $46,345 New position 2025-12-31
Brevan Howard Capital Management LP 0 $0 Sold out 2026-06-30
Jain Global LLC 0 $0 Sold out 2026-06-30
Hudson Bay Capital Management LP 100,532 $115,612 ▲ +46,512 2025-12-31
JACOBS LEVY EQUITY MANAGEMENT, INC 0 $0 Sold out 2026-06-30
HRT FINANCIAL LP 117,549 $135 New position 2025-12-31
Man Group plc 0 $0 Sold out 2026-06-30
OMERS ADMINISTRATION Corp 273,800 $314,870 New position 2025-12-31
Bridgewater Advisors Inc. 0 $0 Sold out 2026-06-30
Jefferies Financial Group Inc. 92,530 $106,410 New position 2025-12-31
Diametric Capital, LP 0 $0 Sold out 2026-06-30
EntryPoint Capital, LLC 33,618 $38,661 New position 2025-12-31
KWB Wealth 0 $0 Sold out 2026-06-30
Jump Financial, LLC 0 $0 Sold out 2026-06-30
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO 35,714 $41,071 New position 2025-12-31
OPPENHEIMER & CO INC 23,500 $27,025 New position 2025-12-31
Quantessence Capital LLC 0 $0 Sold out 2026-06-30
CTC Alternative Strategies, Ltd. 0 $0 Sold out 2026-06-30
PRELUDE CAPITAL MANAGEMENT, LLC 0 $0 Sold out 2026-06-30
Chemistry Wealth Management LLC 0 $0 Sold out 2026-06-30
FWG Holdings, LLC 11,350 $13,166 New position 2025-12-31
Talisman Wealth Advisors LLC 0 $0 Sold out 2026-06-30
Advisory Services Network, LLC 0 $0 Sold out 2026-06-30
EverSource Wealth Advisors, LLC 158 $182 New position 2025-12-31
True Wealth Design, LLC 0 $0 Sold out 2026-06-30
VANGUARD GROUP INC 9,606,549 $11,047,532 New position 2025-12-31
CIBC Private Wealth Group LLC 1,950,000 $2,242,500 New position 2025-12-31
MARSHALL WACE, LLP 1,262,367 $1,451,722 New position 2025-12-31
ExodusPoint Capital Management, LP 268,433 $308,698 New position 2025-12-31
TWO SIGMA ADVISERS, LP 180,977 $208,124 New position 2025-12-31
Lighthouse Investment Partners, LLC 126,600 $145,590 New position 2025-12-31
Monaco Asset Management SAM 117,188 $134,766 New position 2025-12-31
CAXTON ASSOCIATES LLP 71,027 $81,681 New position 2025-12-31
Optiver Holding B.V. 52,595 $60,484 New position 2025-12-31
Vermillion & White Wealth Management Group, LLC 32,000 $36,800 New position 2025-12-31
SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/ 26,650 $30,648 New position 2025-12-31
TIAA TRUST, NATIONAL ASSOCIATION 20,000 $23,000 New position 2025-12-31
StoneX Group Inc. 16,234 $18,669 New position 2025-12-31
LAZARD ASSET MANAGEMENT LLC 14,090 $16,204 New position 2025-12-31
Golden State Wealth Management, LLC 3,700 $4,255 New position 2025-12-31
COMERICA BANK 122 $140 New position 2025-12-31
Virtu Financial LLC 36,468 $42 New position 2025-12-31
CWM, LLC 26,358 $30 New position 2025-12-31
Cambridge Investment Research Advisors, Inc. 21,505 $25 New position 2025-12-31
Motiv8 Investments LLC 200 $0 New position 2025-12-31