ORBIMED ADVISORS LLC
CIK 0001055951
Annualised vol
10.003431%
Beta
0.218345
HHI
313.917263
Top-10 weight
42.0955%
VaR 95%
0.838841%
VaR 99%
1.911067%
Max drawdown
25.421465%
Matched value
86.126838%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| EWTX | UNCHANGED | 15,518,492 | 15,518,492 | 0.0% | 630,516,330 |
| ELVN | REDUCED | 6,776,632 | 7,959,538 | -14.86% | 343,914,074 |
| LLY | ADDED | 257,900 | 236,800 | 8.91% | 309,332,997 |
| MBX | REDUCED | 3,428,736 | 3,637,887 | -5.75% | 189,266,227 |
| SVA | UNCHANGED | 2,718,735 | 2,718,735 | 0.0% | 184,466,170 |
| AZN | ADDED | 915,700 | 670,200 | 36.63% | 171,079,502 |
| GPCR | ADDED | 2,209,400 | 1,475,403 | 49.75% | 118,578,498 |
| SION | REDUCED | 2,555,877 | 3,530,702 | -27.61% | 112,433,029 |
| CRVS | UNCHANGED | 7,165,006 | 7,165,006 | 0.0% | 107,045,190 |
| AVBP | UNCHANGED | 3,027,328 | 3,027,328 | 0.0% | 105,169,375 |
| PRLD | ADDED | 19,404,757 | 16,589,442 | 16.97% | 103,427,354 |
| GH | ADDED | 583,700 | 435,200 | 34.12% | 87,572,511 |
| ARGX | REDUCED | 92,880 | 136,900 | -32.15% | 86,171,278 |
| MRK | UNCHANGED | 663,400 | 663,400 | 0.0% | 85,246,900 |
| EW | REDUCED | 834,900 | 1,230,600 | -32.16% | 75,525,054 |
| DYN | ADDED | 3,235,684 | 2,917,884 | 10.89% | 71,864,542 |
| NTRA | UNCHANGED | 262,000 | 262,000 | 0.0% | 71,119,900 |
| UNH | NEW | 171,100 | - | - | 71,114,293 |
| CGON | ADDED | 972,800 | 948,267 | 2.59% | 69,117,440 |
| SPRY | UNCHANGED | 8,288,510 | 8,288,510 | 0.0% | 66,390,965 |
| COGT | ADDED | 2,681,300 | 1,322,100 | 102.81% | 66,293,810 |
| ASND | ADDED | 244,456 | 181,977 | 34.33% | 65,201,304 |
| HUM | NEW | 164,100 | - | - | 65,183,802 |
| BSX | REDUCED | 1,483,200 | 2,382,100 | -37.74% | 63,302,976 |
| ISRG | REDUCED | 157,900 | 208,700 | -24.34% | 62,793,672 |
| MLYS | ADDED | 2,110,300 | 2,052,900 | 2.8% | 56,935,894 |
| ODTX | NEW | 3,001,198 | - | - | 56,152,415 |
| XENE | REDUCED | 892,471 | 1,059,971 | -15.8% | 53,869,550 |
| ARQT | NEW | 2,042,000 | - | - | 53,541,240 |
| BMY | UNCHANGED | 925,000 | 925,000 | 0.0% | 53,298,500 |
| QTTB | ADDED | 4,127,987 | 2,252,987 | 83.22% | 52,590,554 |
| SYK | REDUCED | 159,100 | 182,500 | -12.82% | 50,091,044 |
| CAI | UNCHANGED | 2,806,811 | 2,806,811 | 0.0% | 50,017,372 |
| TMO | ADDED | 90,700 | 46,500 | 95.05% | 45,473,352 |
| STTK | UNCHANGED | 6,306,127 | 6,306,127 | 0.0% | 43,764,521 |
| UPB | UNCHANGED | 5,693,589 | 5,693,589 | 0.0% | 39,399,636 |
| RYTM | ADDED | 322,900 | 314,100 | 2.8% | 35,851,587 |
| SNDX | ADDED | 1,542,000 | 962,300 | 60.24% | 33,708,120 |
| CMPX | UNCHANGED | 15,219,994 | 15,219,994 | 0.0% | 33,331,787 |
| NKTR | ADDED | 465,346 | 275,000 | 69.22% | 32,485,804 |
| KRYS | ADDED | 83,200 | 69,100 | 20.41% | 30,922,944 |
| AXSM | REDUCED | 117,578 | 213,921 | -45.04% | 28,779,567 |
| RVMD | ADDED | 3,620,500 | 52,000 | 6862.5% | 26,946,965 |
| KNSA | ADDED | 420,600 | 180,599 | 132.89% | 26,897,370 |
| TRVI | REDUCED | 1,430,293 | 2,454,400 | -41.73% | 26,674,964 |
| IRON | REDUCED | 357,535 | 1,067,550 | -66.51% | 26,150,110 |
| RLMD | REDUCED | 3,631,195 | 4,715,864 | -23.0% | 25,127,869 |
| URGN | REDUCED | 676,187 | 875,487 | -22.76% | 24,883,682 |
| STRO | REDUCED | 743,944 | 801,144 | -7.14% | 24,698,941 |
| SVRA | ADDED | 3,959,900 | 635,000 | 523.61% | 24,392,984 |
| NPCE | REDUCED | 1,505,125 | 2,096,527 | -28.21% | 23,916,436 |
| AURA | NEW | 3,333,333 | - | - | 23,666,664 |
| PTGX | ADDED | 192,100 | 42,100 | 356.29% | 23,547,618 |
| ORIC | REDUCED | 2,015,000 | 2,693,929 | -25.2% | 21,822,450 |
| HELP | REDUCED | 3,271,400 | 3,832,843 | -14.65% | 21,623,954 |
| TVTX | NEW | 5,253,000 | - | - | 20,267,280 |
| BCRX | ADDED | 1,852,000 | 1,425,200 | 29.95% | 18,520,000 |
| BIOA | ADDED | 752,153 | 711,811 | 5.67% | 18,435,270 |
| LXEO | ADDED | 3,947,850 | 3,602,450 | 9.59% | 18,377,242 |
| WHWK | REDUCED | 3,934,296 | 4,166,000 | -5.56% | 18,019,076 |
| DFTX | REDUCED | 365,400 | 804,000 | -54.55% | 17,188,416 |
| SYRE | NEW | 186,145 | - | - | 16,525,953 |
| VERA | UNCHANGED | 369,596 | 369,596 | 0.0% | 15,859,364 |
| ALMS | UNCHANGED | 548,163 | 548,163 | 0.0% | 15,425,307 |
| EYPT | UNCHANGED | 1,069,147 | 1,069,147 | 0.0% | 15,288,802 |
| MNPR | NEW | 157,423 | - | - | 14,575,796 |
| TSHA | NEW | 2,000,000 | - | - | 13,620,000 |
| BIIB | UNCHANGED | 61,600 | 61,600 | 0.0% | 13,309,296 |
| SPRB | NEW | 200,000 | - | - | 10,800,000 |
| LFST | ADDED | 947,400 | 500,000 | 89.48% | 10,146,654 |
| ERAS | NEW | 495,900 | - | - | 9,084,888 |
| TARA | NEW | 2,220,000 | - | - | 8,480,400 |
| KROS | UNCHANGED | 759,155 | 759,155 | 0.0% | 8,122,959 |
| JANX | REDUCED | 524,700 | 983,600 | -46.66% | 8,059,392 |
| TECX | UNCHANGED | 226,600 | 226,600 | 0.0% | 7,789,375 |
| ACET | REDUCED | 844,787 | 1,027,944 | -17.82% | 7,298,960 |
| PHVS | UNCHANGED | 205,400 | 205,400 | 0.0% | 7,102,732 |
| ANRO | ADDED | 257,852 | 167,500 | 53.94% | 6,804,714 |
| ZNTL | NEW | 1,390,576 | - | - | 6,744,294 |
| DRUG | ADDED | 93,000 | 40,000 | 132.5% | 6,528,600 |
| XLO | NEW | 592,300 | - | - | 5,674,234 |
| BCAX | REDUCED | 191,100 | 667,300 | -71.36% | 5,673,759 |
| IMA | UNCHANGED | 909,269 | 909,269 | 0.0% | 5,364,687 |
| ALNY | REDUCED | 17,000 | 119,000 | -85.71% | 5,117,510 |
| PALI | UNCHANGED | 2,333,000 | 2,333,000 | 0.0% | 4,875,970 |
| PTCT | UNCHANGED | 49,100 | 49,100 | 0.0% | 4,005,087 |
| AORT | ADDED | 175,000 | 151,000 | 15.89% | 3,932,250 |
| NMRA | NEW | 2,139,882 | - | - | 3,637,799 |
| ACAD | NEW | 137,000 | - | - | 3,466,100 |
| AMLX | NEW | 183,400 | - | - | 3,293,864 |
| TYRA | NEW | 102,000 | - | - | 3,257,880 |
| RAPP | NEW | 76,616 | - | - | 3,192,589 |
| AGMB | NEW | 192,740 | - | - | 2,501,765 |
| TARS | NEW | 35,581 | - | - | 2,239,468 |
| ACRS | NEW | 421,500 | - | - | 2,229,735 |
| CYTK | NEW | 25,800 | - | - | 2,197,902 |
| NSPR | UNCHANGED | 3,133,405 | 3,133,405 | 0.0% | 2,193,697 |
| OCUL | NEW | 220,000 | - | - | 2,160,400 |
| EVMN | NEW | 161,000 | - | - | 2,139,690 |
| BLTE | NEW | 13,300 | - | - | 2,048,001 |
| OVID | NEW | 747,000 | - | - | 2,009,430 |
| EPRX | NEW | 269,000 | - | - | 1,778,090 |
| TRAW | ADDED | 1,203,260 | 605,531 | 98.71% | 1,014,709 |
| MYGN | CLOSED OUT | 0 | 125,000,000 | -100.0% | 0 |
| MDXH | CLOSED OUT | 0 | 124,306,000 | -100.0% | 0 |
| RCEL | CLOSED OUT | 0 | 82,010,995 | -100.0% | 0 |
| VTGN | CLOSED OUT | 0 | 3,060,000 | -100.0% | 0 |
| PFE | CLOSED OUT | 0 | 1,946,500 | -100.0% | 0 |
| ADCT | CLOSED OUT | 0 | 1,318,026 | -100.0% | 0 |
| CARL | CLOSED OUT | 0 | 1,252,600 | -100.0% | 0 |
| CMPS | CLOSED OUT | 0 | 1,150,646 | -100.0% | 0 |
| CCCC | CLOSED OUT | 0 | 856,353 | -100.0% | 0 |
| ALHC | CLOSED OUT | 0 | 791,000 | -100.0% | 0 |
| AVTX | CLOSED OUT | 0 | 475,165 | -100.0% | 0 |
| CGEM | CLOSED OUT | 0 | 243,006 | -100.0% | 0 |
| JBIO | CLOSED OUT | 0 | 185,011 | -100.0% | 0 |
| GILD | CLOSED OUT | 0 | 59,600 | -100.0% | 0 |
| AMGN | CLOSED OUT | 0 | 39,900 | -100.0% | 0 |
| REGN | CLOSED OUT | 0 | 14,700 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| EWTX | UNCHANGED | EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 630,516,330 | 11.68 | 1.5518492E7 |
| ELVN | REDUCED | ENLIVEN THERAPEUTICS INC | COM | 29337E102 | 343,914,074 | 6.37 | 6776632.0 |
| LLY | ADDED | ELI LILLY & CO | COM | 532457108 | 309,332,997 | 5.73 | 257900.0 |
| MBX | REDUCED | MBX BIOSCIENCES INC | COM | 55287L101 | 189,266,227 | 3.51 | 3428736.0 |
| SVA | UNCHANGED | SINOVAC BIOTECH LTD | SHS | P8696W104 | 184,466,170 | 3.42 | 2718735.0 |
| AZN | ADDED | ASTRAZENECA PLC | ORD | G0593M107 | 171,079,502 | 3.17 | 915700.0 |
| GPCR | ADDED | STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 118,578,498 | 2.2 | 2209400.0 |
| SION | REDUCED | SIONNA THERAPEUTICS INC | COM | 829401108 | 112,433,029 | 2.08 | 2555877.0 |
| CRVS | UNCHANGED | CORVUS PHARMACEUTICALS INC | COM | 221015100 | 107,045,190 | 1.98 | 7165006.0 |
| AVBP | UNCHANGED | ARRIVENT BIOPHARMA INC | COM | 04272N102 | 105,169,375 | 1.95 | 3027328.0 |
| GH | ADDED | GUARDANT HEALTH INC | COM | 40131M109 | 87,572,511 | 1.62 | 583700.0 |
| ARGX | REDUCED | ARGENX SE | SPONSORED ADR | 04016X101 | 86,171,278 | 1.6 | 92880.0 |
| MRK | UNCHANGED | MERCK & CO INC | COM | 58933Y105 | 85,246,900 | 1.58 | 663400.0 |
| - | UNIQURE NV | SHS | N90064101 | 83,252,805 | 1.54 | 1807486.0 | |
| - | PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 | 77,035,179 | 1.43 | 230100.0 | |
| EW | REDUCED | EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 75,525,054 | 1.4 | 834900.0 |
| PRLD | ADDED | PRELUDE THERAPEUTICS INC | COM | 74065P101 | 73,151,963 | 1.36 | 1.3724571E7 |
| - | ABIVAX SA | SPONSORED ADS | 00370M103 | 72,829,522 | 1.35 | 546522.0 | |
| DYN | ADDED | DYNE THERAPEUTICS INC | COM | 26818M108 | 71,864,542 | 1.33 | 3235684.0 |
| NTRA | UNCHANGED | NATERA INC | COM | 632307104 | 71,119,900 | 1.32 | 262000.0 |
| CGON | ADDED | CG ONCOLOGY INC | COM | 156944100 | 69,117,440 | 1.28 | 972800.0 |
| UNH | NEW | UNITEDHEALTH GROUP INC | COM | 91324P102 | 66,957,993 | 1.24 | 161100.0 |
| SPRY | UNCHANGED | ARS PHARMACEUTICALS INC | COM | 82835W108 | 66,390,965 | 1.23 | 8288510.0 |
| ASND | ADDED | ASCENDIS PHARMA A/S | ORD SHS | K08588103 | 65,201,304 | 1.21 | 244456.0 |
| HUM | NEW | HUMANA INC | COM | 444859102 | 65,183,802 | 1.21 | 164100.0 |
| COGT | ADDED | COGENT BIOSCIENCES INC | COM | 19240Q201 | 65,066,310 | 1.21 | 1681300.0 |
| BSX | REDUCED | BOSTON SCIENTIFIC CORP | COM | 101137107 | 63,302,976 | 1.17 | 1483200.0 |
| ISRG | REDUCED | INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 62,793,672 | 1.16 | 157900.0 |
| MLYS | ADDED | MINERALYS THERAPEUTICS INC | COM | 603170101 | 56,935,894 | 1.05 | 2110300.0 |
| ODTX | NEW | ODYSSEY THERAPEUTICS INC | COMMON STOCK | 67613T104 | 56,152,415 | 1.04 | 3001198.0 |
| XENE | REDUCED | XENON PHARMACEUTICALS INC | COM | 98420N105 | 53,869,550 | 1.0 | 892471.0 |
| ARQT | NEW | ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 53,541,240 | 0.99 | 2042000.0 |
| BMY | UNCHANGED | BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 53,298,500 | 0.99 | 925000.0 |
| QTTB | ADDED | Q32 BIO INC | COM | 746964105 | 52,590,554 | 0.97 | 4127987.0 |
| SYK | REDUCED | STRYKER CORPORATION | COM | 863667101 | 50,091,044 | 0.93 | 159100.0 |
| CAI | UNCHANGED | CARIS LIFE SCIENCES INC | COM | 142152107 | 50,017,372 | 0.93 | 2806811.0 |
| - | SPDR SERIES TRUST | ST STR SP BIOT | 78464A870 | 47,475,000 | 0.88 | 300000.0 | |
| TMO | ADDED | THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 45,473,352 | 0.84 | 90700.0 |
| - | PALVELLA THERAPEUTICS INC NE | COM | 697947109 | 44,678,455 | 0.83 | 292360.0 | |
| - | ELEVANCE HEALTH INC FORMERLY | COM | 036752103 | 44,357,931 | 0.82 | 114700.0 | |
| STTK | UNCHANGED | SHATTUCK LABS INC | COM | 82024L103 | 43,764,521 | 0.81 | 6306127.0 |
| UPB | UNCHANGED | UPSTREAM BIO INC | COM | 91678A107 | 39,399,636 | 0.73 | 5693589.0 |
| - | CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 37,382,580 | 0.69 | 999000.0 | |
| RYTM | ADDED | RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 35,851,587 | 0.66 | 322900.0 |
| SNDX | ADDED | SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 33,708,120 | 0.62 | 1542000.0 |
| - | FORTE BIOSCIENCES INC | COM NEW | 34962G208 | 33,526,231 | 0.62 | 1577705.0 | |
| CMPX | UNCHANGED | COMPASS THERAPEUTICS INC | COM | 20454B104 | 33,331,787 | 0.62 | 1.5219994E7 |
| NKTR | ADDED | NEKTAR THERAPEUTICS | COM NEW | 640268306 | 32,485,804 | 0.6 | 465346.0 |
| KRYS | ADDED | KRYSTAL BIOTECH INC | COM | 501147102 | 30,922,944 | 0.57 | 83200.0 |
| PRLD | ADDED | PRELUDE THERAPEUTICS INC | NON VOTING | 000000000 | 30,275,391 | 0.56 | 5680186.0 |
| AXSM | REDUCED | AXSOME THERAPEUTICS INC. | COM | 05464T104 | 28,779,567 | 0.53 | 117578.0 |
| KNSA | ADDED | KINIKSA PHARMACEUTICALS INTL | ORD SHS CL A | G52694109 | 26,897,370 | 0.5 | 420600.0 |
| TRVI | REDUCED | TREVI THERAPEUTICS INC | COM | 89532M101 | 26,674,964 | 0.49 | 1430293.0 |
| - | ABIVAX SA | SPONSORED ADS | 00370M103 | 26,652,000 | 0.49 | 200000.0 | |
| IRON | REDUCED | DISC MEDICINE INC | COM | 254604101 | 26,150,110 | 0.48 | 357535.0 |
| - | WEST PHARMACEUTICAL SVSC INC | COM | 955306105 | 25,345,400 | 0.47 | 70600.0 | |
| RLMD | REDUCED | RELMADA THERAPEUTICS INC | COM | 75955J402 | 25,127,869 | 0.47 | 3631195.0 |
| URGN | REDUCED | UROGEN PHARMA LTD | COM | M96088105 | 24,883,682 | 0.46 | 676187.0 |
| STRO | REDUCED | SUTRO BIOPHARMA INC | COM SHS | 869367201 | 24,698,941 | 0.46 | 743944.0 |
| SVRA | ADDED | SAVARA INC | COM | 805111101 | 24,392,984 | 0.45 | 3959900.0 |
| NPCE | REDUCED | NEUROPACE INC | COM | 641288105 | 23,916,436 | 0.44 | 1505125.0 |
| AURA | NEW | AURA BIOSCIENCES INC | COM | 05153U107 | 23,666,664 | 0.44 | 3333333.0 |
| ORIC | REDUCED | ORIC PHARMACEUTICALS INC | COM | 68622P109 | 21,822,450 | 0.4 | 2015000.0 |
| HELP | REDUCED | CYBIN INC | COM NEW | 23256X407 | 21,623,954 | 0.4 | 3271400.0 |
| BCRX | ADDED | BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | 18,520,000 | 0.34 | 1852000.0 |
| BIOA | ADDED | BIOAGE LABS INC | COM | 09077V100 | 18,435,270 | 0.34 | 752153.0 |
| PTGX | ADDED | PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 18,387,000 | 0.34 | 150000.0 |
| LXEO | ADDED | LEXEO THERAPEUTICS INC | COM | 52886X107 | 18,377,242 | 0.34 | 3947850.0 |
| WHWK | REDUCED | WHITEHAWK THERAPEUTICS INC | COM | 00032Q104 | 18,019,076 | 0.33 | 3934296.0 |
| DFTX | REDUCED | DEFINIUM THERAPEUTICS INC | COM SHS | 24477V105 | 17,188,416 | 0.32 | 365400.0 |
| SYRE | NEW | SPYRE THERAPEUTICS INC | COM NEW | 00773J202 | 16,525,953 | 0.31 | 186145.0 |
| - | CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 | 16,295,752 | 0.3 | 1737287.0 | |
| VERA | UNCHANGED | VERA THERAPEUTICS INC | CL A | 92337R101 | 15,859,364 | 0.29 | 369596.0 |
| ALMS | UNCHANGED | ALUMIS INC | COM | 022307102 | 15,425,307 | 0.29 | 548163.0 |
| EYPT | UNCHANGED | EYEPOINT INC | COM NEW | 30233G209 | 15,288,802 | 0.28 | 1069147.0 |
| - | WATERS CORP | COM | 941848103 | 15,114,112 | 0.28 | 40300.0 | |
| MNPR | NEW | MONOPAR THERAPEUTICS INC | COM NEW | 61023L207 | 14,575,796 | 0.27 | 157423.0 |
| TVTX | NEW | TRAVERE THERAPEUTICS INC | COM | 89422G107 | 14,372,930 | 0.27 | 253000.0 |
| TSHA | NEW | TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 13,620,000 | 0.25 | 2000000.0 |
| BIIB | UNCHANGED | BIOGEN INC | COM | 09062X103 | 13,309,296 | 0.25 | 61600.0 |
| RVMD | ADDED | REVOLUTION MEDICINES INC | COM | 76155X100 | 13,203,240 | 0.24 | 70500.0 |
| - | DIANTHUS THERAPEUTICS INC | COM | 252828108 | 11,210,200 | 0.21 | 115000.0 | |
| SPRB | NEW | SPRUCE BIOSCIENCES INC | COM NEW | 85209E208 | 10,800,000 | 0.2 | 200000.0 |
| LFST | ADDED | LIFESTANCE HEALTH GROUP INC | COM | 53228F101 | 10,146,654 | 0.19 | 947400.0 |
| RVMD | ADDED | REVOLUTION MEDICINES INC | COM | 76155X100 | 9,364,000 | 0.17 | 50000.0 |
| ERAS | NEW | ERASCA INC | COM | 29479A108 | 9,084,888 | 0.17 | 495900.0 |
| TARA | NEW | PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 8,480,400 | 0.16 | 2220000.0 |
| KROS | UNCHANGED | KEROS THERAPEUTICS INC | COM | 492327101 | 8,122,959 | 0.15 | 759155.0 |
| JANX | REDUCED | JANUX THERAPEUTICS INC | COM | 47103J105 | 8,059,392 | 0.15 | 524700.0 |
| TECX | UNCHANGED | TECTONIC THERAPEUTIC INC | COM | 878972108 | 7,789,375 | 0.14 | 226600.0 |
| ACET | REDUCED | ADICET BIO INC | COM NEW | 007002207 | 7,298,960 | 0.14 | 844787.0 |
| PHVS | UNCHANGED | PHARVARIS N V | COM | N69605108 | 7,102,732 | 0.13 | 205400.0 |
| ANRO | ADDED | ALTO NEUROSCIENCE INC | COM SHS | 02157Q109 | 6,804,714 | 0.13 | 257852.0 |
| ZNTL | NEW | ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 | 6,744,294 | 0.12 | 1390576.0 |
| DRUG | ADDED | BRIGHT MINDS BIOSCIENCES INC | COM NEW | 10919W405 | 6,528,600 | 0.12 | 93000.0 |
| - | PALVELLA THERAPEUTICS INC NE | COM | 697947109 | 6,112,800 | 0.11 | 40000.0 | |
| - | ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 5,933,150 | 0.11 | 2866256.0 | |
| TVTX | NEW | TRAVERE THERAPEUTICS INC | NOTE 0.500% 5/1 | 89422GAB3 | 5,894,350 | 0.11 | 5000000.0 |
| XLO | NEW | XILIO THERAPEUTICS INC | COM | 98422T209 | 5,674,234 | 0.11 | 592300.0 |
| BCAX | REDUCED | BICARA THERAPEUTICS INC | COM | 055477103 | 5,673,759 | 0.11 | 191100.0 |
| IMA | UNCHANGED | IMAGENEBIO INC | COM | 45175G207 | 5,364,687 | 0.1 | 909269.0 |
| PTGX | ADDED | PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 5,160,618 | 0.1 | 42100.0 |
| ALNY | REDUCED | ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 5,117,510 | 0.09 | 17000.0 |
| PALI | UNCHANGED | PALISADE BIO INC | COM | 696389402 | 4,875,970 | 0.09 | 2333000.0 |
| RVMD | ADDED | REVOLUTION MEDICINES INC | NOTE 0.500% 5/0 | 76155XAA8 | 4,379,725 | 0.08 | 3500000.0 |
| - | ATAIBECKLEY INC | COM SHS | 04650F101 | 4,202,825 | 0.08 | 797500.0 | |
| UNH | NEW | UNITEDHEALTH GROUP INC | COM | 91324P102 | 4,156,300 | 0.08 | 10000.0 |
| PTCT | UNCHANGED | PTC THERAPEUTICS INC | COM | 69366J200 | 4,005,087 | 0.07 | 49100.0 |
| AORT | ADDED | ARTIVION INC | COM | 228903100 | 3,932,250 | 0.07 | 175000.0 |
| - | ELEVANCE HEALTH INC FORMERLY | COM | 036752103 | 3,867,300 | 0.07 | 10000.0 | |
| NMRA | NEW | NEUMORA THERAPEUTICS INC. | COM | 640979100 | 3,637,799 | 0.07 | 2139882.0 |
| ACAD | NEW | ACADIA PHARMACEUTICALS INC | COM | 004225108 | 3,466,100 | 0.06 | 137000.0 |
| AMLX | NEW | AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 3,293,864 | 0.06 | 183400.0 |
| TYRA | NEW | TYRA BIOSCIENCES INC | COM | 90240B106 | 3,257,880 | 0.06 | 102000.0 |
| RAPP | NEW | RAPPORT THERAPEUTICS INC | COM | 75383L102 | 3,192,589 | 0.06 | 76616.0 |
| AGMB | NEW | AGOMAB THERAPEUTICS NV | SPONSORED ADS | 00860C102 | 2,501,765 | 0.05 | 192740.0 |
| TARS | NEW | TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 2,239,468 | 0.04 | 35581.0 |
| ACRS | NEW | ACLARIS THERAPEUTICS INC | COM | 00461U105 | 2,229,735 | 0.04 | 421500.0 |
| CYTK | NEW | CYTOKINETICS INC | COM NEW | 23282W605 | 2,197,902 | 0.04 | 25800.0 |
| NSPR | UNCHANGED | INSPIREMD INC | COM | 45779A846 | 2,193,697 | 0.04 | 3133405.0 |
| OCUL | NEW | OCULAR THERAPEUTIX INC | COM | 67576A100 | 2,160,400 | 0.04 | 220000.0 |
| EVMN | NEW | EVOMMUNE INC | COM SHS | 30054Y107 | 2,139,690 | 0.04 | 161000.0 |
| BLTE | NEW | BELITE BIO INC | SPONSORED ADS | 07782B104 | 2,048,001 | 0.04 | 13300.0 |
| OVID | NEW | OVID THERAPEUTICS INC | COM | 690469101 | 2,009,430 | 0.04 | 747000.0 |
| EPRX | NEW | EUPRAXIA PHARMACEUTICALS INC | COM | 29842P105 | 1,778,090 | 0.03 | 269000.0 |
| - | SELLAS LIFE SCIENCES GROUP I | COM NEW | 81642T209 | 1,365,300 | 0.03 | 92500.0 | |
| COGT | ADDED | COGENT BIOSCIENCES INC | NOTE 1.625%11/1 | 19240QAA0 | 1,227,500 | 0.02 | 1000000.0 |
| - | VIRIDIAN THERAPEUTICS INC | NOTE 1.750% 5/1 | 92790CAB0 | 1,072,670 | 0.02 | 1000000.0 | |
| TRAW | ADDED | TRAWS PHARMA INC | COM NEW | 68232V884 | 1,014,709 | 0.02 | 1203260.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 5,396,779,685 | 129 | 10.003431 | 0.218345 | 25.421465 |
| 2026-03-31 | 2026-05-15 | 5,045,363,608 | 114 | 9.630359 | 0.225414 | 25.256025 |
| 2025-12-31 | 2026-02-17 | 4,899,391,958 | 108 | 9.446914 | 0.293328 | 21.595191 |
| 2025-09-30 | 2025-11-14 | 4,255,380,174 | 110 | 9.260324 | 0.295985 | 17.997807 |
| 2025-03-31 | 2025-05-15 | 4,194,646,405 | 111 | 10.38577 | 0.370608 | 17.201306 |
| 2024-12-31 | 2025-02-14 | 4,861,409,522 | 119 | 10.390333 | 0.360545 | 19.961163 |