TCG Crossover Management, LLC
CIK 0001839948
Annualised vol
15.02124%
Beta
0.156248
HHI
617.678228
Top-10 weight
57.448074%
VaR 95%
1.198534%
VaR 99%
3.120945%
Max drawdown
47.441889%
Matched value
93.716448%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| ABVX | REDUCED | 6,007,834 | 6,481,085 | -7.3% | 800,603,959 |
| TNGX | REDUCED | 9,081,201 | 10,531,071 | -13.77% | 283,878,343 |
| CGON | UNCHANGED | 3,670,206 | 3,670,206 | 0.0% | 260,768,136 |
| COGT | REDUCED | 4,854,436 | 4,946,894 | -1.87% | 187,866,673 |
| IMVT | UNCHANGED | 4,457,988 | 4,457,988 | 0.0% | 171,766,278 |
| SYRE | UNCHANGED | 1,900,582 | 1,900,582 | 0.0% | 168,733,670 |
| MIRM | UNCHANGED | 1,062,049 | 1,062,049 | 0.0% | 124,334,076 |
| ZLAB | NEW | 6,137,627 | - | - | 116,614,913 |
| AMLX | UNCHANGED | 6,243,812 | 6,243,812 | 0.0% | 112,138,864 |
| GLUE | UNCHANGED | 4,622,151 | 4,622,151 | 0.0% | 111,856,054 |
| BCRX | UNCHANGED | 11,020,968 | 11,020,968 | 0.0% | 110,209,680 |
| VOR | UNCHANGED | 5,673,078 | 5,673,078 | 0.0% | 104,441,366 |
| TYRA | UNCHANGED | 3,248,980 | 3,248,980 | 0.0% | 103,772,421 |
| DYN | UNCHANGED | 4,615,144 | 4,615,144 | 0.0% | 102,502,348 |
| IRON | UNCHANGED | 1,341,862 | 1,341,862 | 0.0% | 98,143,787 |
| RLAY | UNCHANGED | 4,273,356 | 4,273,356 | 0.0% | 79,954,491 |
| SVRA | UNCHANGED | 12,362,205 | 12,362,205 | 0.0% | 76,151,183 |
| AURA | NEW | 9,533,333 | - | - | 67,686,664 |
| RVMD | REDUCED | 340,899 | 576,473 | -40.86% | 63,843,565 |
| TRAX | NEW | 2,895,304 | - | - | 58,253,516 |
| KOD | UNCHANGED | 1,445,538 | 1,445,538 | 0.0% | 56,318,161 |
| AVTX | ADDED | 3,017,120 | 738,383 | 308.61% | 55,756,378 |
| LBRX | REDUCED | 1,447,310 | 1,839,489 | -21.32% | 46,972,446 |
| IPSC | UNCHANGED | 17,754,430 | 17,754,430 | 0.0% | 43,401,690 |
| TECX | UNCHANGED | 1,204,891 | 1,204,891 | 0.0% | 41,418,128 |
| XNCR | UNCHANGED | 2,452,138 | 2,452,138 | 0.0% | 39,479,422 |
| EDIT | NEW | 11,111,111 | - | - | 36,000,000 |
| MBX | UNCHANGED | 650,000 | 650,000 | 0.0% | 35,880,000 |
| SLN | UNCHANGED | 3,033,560 | 3,033,560 | 0.0% | 33,308,489 |
| IFRX | NEW | 14,500,000 | - | - | 32,480,000 |
| ALT | NEW | 10,000,000 | - | - | 30,400,000 |
| JANX | UNCHANGED | 1,789,617 | 1,789,617 | 0.0% | 27,488,517 |
| CATX | UNCHANGED | 7,915,567 | 7,915,567 | 0.0% | 26,992,083 |
| AGMB | UNCHANGED | 2,053,233 | 2,053,233 | 0.0% | 26,650,964 |
| BHVN | REDUCED | 1,779,952 | 4,631,317 | -61.57% | 26,485,686 |
| AKTS | NEW | 696,560 | - | - | 22,450,129 |
| ALEC | UNCHANGED | 10,000,000 | 10,000,000 | 0.0% | 20,100,000 |
| MNPR | ADDED | 203,327 | 132,103 | 53.92% | 18,826,047 |
| OCUL | UNCHANGED | 1,647,752 | 1,647,752 | 0.0% | 16,180,925 |
| ADCT | UNCHANGED | 11,390,175 | 11,390,175 | 0.0% | 12,187,487 |
| ALXO | REDUCED | 5,655,487 | 13,011,849 | -56.54% | 11,706,858 |
| TRDA | REDUCED | 1,060,230 | 2,287,500 | -53.65% | 7,803,293 |
| CGEM | UNCHANGED | 406,786 | 406,786 | 0.0% | 7,407,573 |
| ARVN | REDUCED | 707,098 | 2,387,461 | -70.38% | 5,875,984 |
| KRRO | UNCHANGED | 416,301 | 416,301 | 0.0% | 5,486,847 |
| LONA | UNCHANGED | 464,398 | 464,398 | 0.0% | 4,267,818 |
| JATT | NEW | 200,000 | - | - | 2,272,000 |
| CNTX | UNCHANGED | 2,682,696 | 2,682,696 | 0.0% | 1,485,945 |
| EIKN | NEW | 37,902 | - | - | 494,621 |
| FULC | CLOSED OUT | 0 | 5,250,000 | -100.0% | 0 |
| VTGN | CLOSED OUT | 0 | 2,676,580 | -100.0% | 0 |
| URGN | CLOSED OUT | 0 | 405,365 | -100.0% | 0 |
| UPB | CLOSED OUT | 0 | 181,063 | -100.0% | 0 |
| GPCR | CLOSED OUT | 0 | 140,411 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| ABVX | REDUCED | ABIVAX SA AMERICAN DEPOSITARY SHARES | COMM | 00370M103 | 800,603,959 | 19.24 | 6007834.0 |
| TNGX | REDUCED | TANGO THERAPEUTICS INC | COMM | 87583X109 | 283,878,343 | 6.82 | 9081201.0 |
| CGON | UNCHANGED | CG ONCOLOGY INC | COMM | 156944100 | 260,768,136 | 6.27 | 3670206.0 |
| COGT | REDUCED | COGENT BIOSCIENCES INC | COMM | 19240Q201 | 187,866,673 | 4.52 | 4854436.0 |
| IMVT | UNCHANGED | IMMUNOVANT INC | COMM | 45258J102 | 171,766,278 | 4.13 | 4457988.0 |
| SYRE | UNCHANGED | SPYRE THERAPEUTICS INC | COMM | 00773J202 | 168,733,670 | 4.06 | 1900582.0 |
| - | DIANTHUS THERAPEUTICS INC | COMM | 252828108 | 163,437,308 | 3.93 | 1676624.0 | |
| MIRM | UNCHANGED | MIRUM PHARMACEUTICALS INC | COMM | 604749101 | 124,334,076 | 2.99 | 1062049.0 |
| ZLAB | NEW | ZAI LAB LTD-ADR | ADRS | 98887Q104 | 116,614,913 | 2.8 | 6137627.0 |
| AMLX | UNCHANGED | AMYLYX PHARMACEUTICALS INC | COMM | 03237H101 | 112,138,864 | 2.7 | 6243812.0 |
| GLUE | UNCHANGED | MONTE ROSA THERAPEUTICS INC | COMM | 61225M102 | 111,856,054 | 2.69 | 4622151.0 |
| BCRX | UNCHANGED | BIOCRYST PHARMACEUTICALS INC | COMM | 09058V103 | 110,209,680 | 2.65 | 1.1020968E7 |
| VOR | UNCHANGED | VOR BIOPHARMA INC | COMM | 929033207 | 104,441,366 | 2.51 | 5673078.0 |
| TYRA | UNCHANGED | TYRA BIOSCIENCES INC | COMM | 90240B106 | 103,772,421 | 2.49 | 3248980.0 |
| DYN | UNCHANGED | DYNE THERAPEUTICS INC | COMM | 26818M108 | 102,502,348 | 2.46 | 4615144.0 |
| IRON | UNCHANGED | DISC MEDICINE INC | COMM | 254604101 | 98,143,787 | 2.36 | 1341862.0 |
| RLAY | UNCHANGED | RELAY THERAPEUTICS INC | COMM | 75943R102 | 79,954,491 | 1.92 | 4273356.0 |
| SVRA | UNCHANGED | SAVARA INC | COMM | 805111101 | 76,151,183 | 1.83 | 1.2362205E7 |
| AURA | NEW | AURA BIOSCIENCES INC | COMM | 05153U107 | 67,686,664 | 1.63 | 9533333.0 |
| RVMD | REDUCED | REVOLUTION MEDICINES INC | COMM | 76155X100 | 63,843,565 | 1.53 | 340899.0 |
| TRAX | NEW | FIRST TRACKS BIOTHERAPEUTICS | COMM | 337185102 | 58,253,516 | 1.4 | 2895304.0 |
| KOD | UNCHANGED | KODIAK SCIENCES INC | COMM | 50015M109 | 56,318,161 | 1.35 | 1445538.0 |
| AVTX | ADDED | AVALO THERAPEUTICS INC | COMM | 05338F306 | 55,756,378 | 1.34 | 3017120.0 |
| LBRX | REDUCED | LB PHARMACEUTICALS INC | COMM | 50180M108 | 46,972,446 | 1.13 | 1447310.0 |
| IPSC | UNCHANGED | CENTURY THERAPEUTICS INC | COMM | 15673T100 | 43,401,690 | 1.04 | 1.775443E7 |
| TECX | UNCHANGED | TECTONIC THERAPEUTIC INC | COMM | 878972108 | 41,418,128 | 1.0 | 1204891.0 |
| XNCR | UNCHANGED | XENCOR INC | COMM | 98401F105 | 39,479,422 | 0.95 | 2452138.0 |
| - | SURROZEN INC | COMM | 86889P208 | 38,226,971 | 0.92 | 1473101.0 | |
| EDIT | NEW | EDITAS MEDICINE INC | COMM | 28106W103 | 36,000,000 | 0.87 | 1.1111111E7 |
| MBX | UNCHANGED | MBX BIOSCIENCES INC | COMM | 55287L101 | 35,880,000 | 0.86 | 650000.0 |
| - | PHARVARIS BV | COMM | N69605108 | 34,864,559 | 0.84 | 1008229.0 | |
| SLN | UNCHANGED | SILENCE THERAPEUTICS PLC | ADRS | 82686Q101 | 33,308,489 | 0.8 | 3033560.0 |
| IFRX | NEW | INFLARX N V | COMM | N44821101 | 32,480,000 | 0.78 | 1.45E7 |
| ALT | NEW | ALTIMMUNE INC | COMM | 02155H200 | 30,400,000 | 0.73 | 1.0E7 |
| JANX | UNCHANGED | JANUX THERAPEUTICS INC | COMM | 47103J105 | 27,488,517 | 0.66 | 1789617.0 |
| CATX | UNCHANGED | PERSPECTIVE THERAPEUTICS INC | COMM | 46489V302 | 26,992,083 | 0.65 | 7915567.0 |
| AGMB | UNCHANGED | AGOMAB THERAPEUTICS NV | ADRS | 00860C102 | 26,650,964 | 0.64 | 2053233.0 |
| BHVN | REDUCED | BIOHAVEN LTD | COMM | G1110E107 | 26,485,686 | 0.64 | 1779952.0 |
| AKTS | NEW | AKTIS ONCOLOGY INC | COMM | 01021M104 | 22,450,129 | 0.54 | 696560.0 |
| ALEC | UNCHANGED | ALECTOR INC | COMM | 014442107 | 20,100,000 | 0.48 | 1.0E7 |
| - | FORTE BIOSCIENCES INC | COMM | 34962G208 | 19,550,000 | 0.47 | 920000.0 | |
| MNPR | ADDED | MONOPAR THERAPEUTICS INC | COMM | 61023L207 | 18,826,047 | 0.45 | 203327.0 |
| OCUL | UNCHANGED | OCULAR THERAPEUTIX INC | COMM | 67576A100 | 16,180,925 | 0.39 | 1647752.0 |
| ADCT | UNCHANGED | ADC THERAPEUTICS SA | COMM | H0036K147 | 12,187,487 | 0.29 | 1.1390175E7 |
| ALXO | REDUCED | ALX ONCOLOGY HOLDINGS INC | COMM | 00166B105 | 11,706,858 | 0.28 | 5655487.0 |
| TRDA | REDUCED | ENTRADA THERAPEUTICS INC | COMM | 29384C108 | 7,803,293 | 0.19 | 1060230.0 |
| CGEM | UNCHANGED | CULLINAN THERAPEUTICS INC | COMM | 230031106 | 7,407,573 | 0.18 | 406786.0 |
| ARVN | REDUCED | ARVINAS HOLDING CO LLC | COMM | 04335A105 | 5,875,984 | 0.14 | 707098.0 |
| KRRO | UNCHANGED | KORRO BIO INC | COMM | 500946108 | 5,486,847 | 0.13 | 416301.0 |
| - | RESEARCH ALLIANCE CORP CL A | COMM | G75226103 | 5,350,000 | 0.13 | 500000.0 | |
| LONA | UNCHANGED | LEONABIO INC | COMM | 04746L203 | 4,267,818 | 0.1 | 464398.0 |
| JATT | NEW | JATT II ACQUISITION CORP | COMM | G50765109 | 2,272,000 | 0.05 | 200000.0 |
| CNTX | UNCHANGED | CONTEXT THERAPEUTICS INC | COMM | 21077P108 | 1,485,945 | 0.04 | 2682696.0 |
| EIKN | NEW | EIKON THERAPEUTICS INC | COMM | 282564103 | 494,621 | 0.01 | 37902.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 4,160,526,316 | 54 | 15.02124 | 0.156248 | 47.441889 |
| 2026-03-31 | 2026-05-15 | 3,495,390,908 | 49 | 14.366569 | 0.147859 | 47.17207 |
| 2025-12-31 | 2026-02-17 | 3,021,699,270 | 43 | 14.795911 | 0.137643 | 48.734642 |
| 2025-09-30 | 2025-11-17 | 2,032,902,053 | 40 | 13.494177 | 0.124868 | 45.888545 |
| 2025-03-31 | 2025-05-14 | 733,085,569 | 38 | 11.568623 | 0.112766 | 38.883736 |
| 2024-12-31 | 2025-02-14 | 1,023,348,505 | 38 | 11.806009 | 0.115177 | 42.469934 |