Casdin Capital, LLC
CIK 0001534261
Annualised vol
21.129056%
Beta
0.390638
HHI
1104.868906
Top-10 weight
77.359229%
VaR 95%
1.988455%
VaR 99%
4.111804%
Max drawdown
37.225986%
Matched value
97.624492%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| RVMD | UNCHANGED | 2,577,333 | 2,577,333 | 0.0% | 482,682,924 |
| RLAY | ADDED | 16,035,240 | 14,418,574 | 11.21% | 300,019,340 |
| WGS | ADDED | 3,707,164 | 3,007,164 | 23.28% | 254,496,809 |
| BLFS | REDUCED | 4,655,000 | 5,957,165 | -21.86% | 131,457,200 |
| ILMN | UNCHANGED | 530,000 | 530,000 | 0.0% | 93,189,900 |
| LAB | UNCHANGED | 88,783,856 | 88,783,856 | 0.0% | 73,042,478 |
| GPCR | UNCHANGED | 1,175,000 | 1,175,000 | 0.0% | 63,062,250 |
| DNLI | ADDED | 2,045,000 | 1,840,000 | 11.14% | 52,597,400 |
| NGNE | ADDED | 1,545,361 | 1,420,361 | 8.8% | 48,601,603 |
| BEAM | UNCHANGED | 1,350,000 | 1,350,000 | 0.0% | 46,332,000 |
| TXG | REDUCED | 1,050,000 | 2,275,000 | -53.85% | 40,257,000 |
| PSNL | ADDED | 2,550,000 | 1,600,000 | 59.38% | 34,170,000 |
| GRAL | ADDED | 480,000 | 230,000 | 108.7% | 32,769,600 |
| GH | REDUCED | 185,000 | 315,000 | -41.27% | 27,755,550 |
| MAZE | ADDED | 843,857 | 758,857 | 11.2% | 25,180,693 |
| HIMS | UNCHANGED | 700,000 | 700,000 | 0.0% | 24,269,000 |
| ALNY | UNCHANGED | 75,000 | 75,000 | 0.0% | 22,577,250 |
| TSHA | UNCHANGED | 3,250,000 | 3,250,000 | 0.0% | 22,132,500 |
| AGMB | UNCHANGED | 1,550,000 | 1,550,000 | 0.0% | 20,119,000 |
| SEPN | UNCHANGED | 553,268 | 553,268 | 0.0% | 18,528,945 |
| PBLS | NEW | 645,690 | - | - | 17,672,535 |
| SION | NEW | 400,000 | - | - | 17,596,000 |
| VCYT | UNCHANGED | 276,308 | 276,308 | 0.0% | 16,227,569 |
| ANL | ADDED | 1,250,000 | 538,461 | 132.14% | 14,375,000 |
| PRME | UNCHANGED | 3,167,175 | 3,167,175 | 0.0% | 11,686,876 |
| ABSI | UNCHANGED | 973,260 | 973,260 | 0.0% | 11,280,083 |
| DGX | UNCHANGED | 50,000 | 50,000 | 0.0% | 10,597,500 |
| SRPT | NEW | 470,000 | - | - | 8,445,900 |
| NTLA | UNCHANGED | 355,000 | 355,000 | 0.0% | 6,006,600 |
| MRNA | UNCHANGED | 75,000 | 75,000 | 0.0% | 5,252,250 |
| IRON | UNCHANGED | 65,000 | 65,000 | 0.0% | 4,754,100 |
| GLUE | UNCHANGED | 186,014 | 186,014 | 0.0% | 4,501,539 |
| IPSC | UNCHANGED | 1,228,190 | 1,228,190 | 0.0% | 3,009,066 |
| CTNM | UNCHANGED | 148,333 | 148,333 | 0.0% | 2,431,178 |
| EDIT | NEW | 445,000 | - | - | 1,441,800 |
| KARD | NEW | 50,000 | - | - | 1,192,500 |
| DNA | UNCHANGED | 36,493 | 36,493 | 0.0% | 361,646 |
| TNYA | UNCHANGED | 361,969 | 361,969 | 0.0% | 267,531 |
| MLTX | CLOSED OUT | 0 | 450,000 | -100.0% | 0 |
| TEM | CLOSED OUT | 0 | 294,127 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| RVMD | UNCHANGED | REVOLUTION MEDICINES INC | COM | 76155X100 | 482,682,924 | 24.16 | 2577333.0 |
| RLAY | ADDED | RELAY THERAPEUTICS INC | COM | 75943R102 | 300,019,340 | 15.02 | 1.603524E7 |
| WGS | ADDED | GENEDX HOLDINGS CORP | COM CL A | 81663L200 | 254,496,809 | 12.74 | 3707164.0 |
| BLFS | REDUCED | BIOLIFE SOLUTIONS INC | COM NEW | 09062W204 | 131,457,200 | 6.58 | 4655000.0 |
| ILMN | UNCHANGED | ILLUMINA INC | COM | 452327109 | 93,189,900 | 4.66 | 530000.0 |
| LAB | UNCHANGED | STANDARD BIOTOOLS INC | COM | 34385P108 | 73,042,478 | 3.66 | 8.8783856E7 |
| GPCR | UNCHANGED | STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 63,062,250 | 3.16 | 1175000.0 |
| DNLI | ADDED | DENALI THERAPEUTICS INC | COM | 24823R105 | 52,597,400 | 2.63 | 2045000.0 |
| NGNE | ADDED | NEUROGENE INC | COM | 64135M105 | 48,601,603 | 2.43 | 1545361.0 |
| BEAM | UNCHANGED | BEAM THERAPEUTICS INC | COM | 07373V105 | 46,332,000 | 2.32 | 1350000.0 |
| TXG | REDUCED | 10X GENOMICS INC | CL A COM | 88025U109 | 40,257,000 | 2.02 | 1050000.0 |
| - | SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 36,575,000 | 1.83 | 665000.0 | |
| PSNL | ADDED | PERSONALIS INC | COM | 71535D106 | 34,170,000 | 1.71 | 2550000.0 |
| GRAL | ADDED | GRAIL INC | COM | 384747101 | 32,769,600 | 1.64 | 480000.0 |
| GH | REDUCED | GUARDANT HEALTH INC | COM | 40131M109 | 27,755,550 | 1.39 | 185000.0 |
| MAZE | ADDED | MAZE THERAPEUTICS INC | COM | 578784100 | 25,180,693 | 1.26 | 843857.0 |
| HIMS | UNCHANGED | HIMS & HERS HEALTH INC | COM CL A | 433000106 | 24,269,000 | 1.21 | 700000.0 |
| ALNY | UNCHANGED | ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 22,577,250 | 1.13 | 75000.0 |
| TSHA | UNCHANGED | TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 22,132,500 | 1.11 | 3250000.0 |
| AGMB | UNCHANGED | AGOMAB THERAPEUTICS NV | SPONSORED ADS | 00860C102 | 20,119,000 | 1.01 | 1550000.0 |
| SEPN | UNCHANGED | SEPTERNA INC | COM | 81734D104 | 18,528,945 | 0.93 | 553268.0 |
| PBLS | NEW | PARABILIS MEDICINES INC | COM | 698955101 | 17,672,535 | 0.88 | 645690.0 |
| SION | NEW | SIONNA THERAPEUTICS INC | COM | 829401108 | 17,596,000 | 0.88 | 400000.0 |
| VCYT | UNCHANGED | VERACYTE INC | COM | 92337F107 | 16,227,569 | 0.81 | 276308.0 |
| ANL | ADDED | ADLAI NORTYE LTD | SPONSORED ADS | 00704R109 | 14,375,000 | 0.72 | 1250000.0 |
| PRME | UNCHANGED | PRIME MEDICINE INC | COM | 74168J101 | 11,686,876 | 0.58 | 3167175.0 |
| ABSI | UNCHANGED | ABSCI CORPORATION | COM | 00091E109 | 11,280,083 | 0.56 | 973260.0 |
| DGX | UNCHANGED | QUEST DIAGNOSTICS INC | COM | 74834L100 | 10,597,500 | 0.53 | 50000.0 |
| SRPT | NEW | SAREPTA THERAPEUTICS INC | COM | 803607100 | 8,445,900 | 0.42 | 470000.0 |
| - | UNIQURE NV | SHS | N90064101 | 6,909,000 | 0.35 | 150000.0 | |
| NTLA | UNCHANGED | INTELLIA THERAPEUTICS INC | COM | 45826J105 | 6,006,600 | 0.3 | 355000.0 |
| MRNA | UNCHANGED | MODERNA INC | COM | 60770K107 | 5,252,250 | 0.26 | 75000.0 |
| IRON | UNCHANGED | DISC MEDICINE INC | COM | 254604101 | 4,754,100 | 0.24 | 65000.0 |
| GLUE | UNCHANGED | MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 4,501,539 | 0.23 | 186014.0 |
| IPSC | UNCHANGED | CENTURY THERAPEUTICS INC | COM | 15673T100 | 3,009,066 | 0.15 | 1228190.0 |
| CTNM | UNCHANGED | CONTINEUM THERAPEUTICS INC | CL A | 21217B100 | 2,431,178 | 0.12 | 148333.0 |
| - | BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | 107924102 | 2,151,217 | 0.11 | 282312.0 | |
| EDIT | NEW | EDITAS MEDICINE INC | COM | 28106W103 | 1,441,800 | 0.07 | 445000.0 |
| - | PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 1,215,929 | 0.06 | 723767.0 | |
| KARD | NEW | KARDIGAN INC | COM | 485925101 | 1,192,500 | 0.06 | 50000.0 |
| - | RECURSION PHARMACEUTICALS IN | CL A | 75629V104 | 606,735 | 0.03 | 165323.0 | |
| DNA | UNCHANGED | GINKGO BIOWORKS HOLDINGS INC | CL A NEW | 37611X209 | 361,646 | 0.02 | 36493.0 |
| TNYA | UNCHANGED | TENAYA THERAPEUTICS INC | COM | 87990A106 | 267,531 | 0.01 | 361969.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 1,997,798,996 | 43 | 21.129056 | 0.390638 | 37.225986 |
| 2026-03-31 | 2026-05-15 | 1,320,591,769 | 40 | 19.558815 | 0.360124 | 33.070257 |
| 2025-12-31 | 2026-02-17 | 1,609,916,188 | 38 | 20.139808 | 0.326548 | 24.100353 |
| 2025-09-30 | 2025-11-14 | 1,199,325,239 | 32 | 20.816805 | 0.301485 | 27.059271 |
| 2025-03-31 | 2025-05-15 | 1,223,806,401 | 44 | 19.790309 | 0.314653 | 25.69812 |
| 2024-12-31 | 2025-02-14 | 1,502,747,643 | 39 | 17.78596 | 0.356133 | 19.475564 |