Sio Capital Management, LLC
CIK 0001482416
Annualised vol
8.749281%
Beta
0.176098
HHI
369.288368
Top-10 weight
48.641578%
VaR 95%
0.808229%
VaR 99%
1.750804%
Max drawdown
28.565762%
Matched value
78.184971%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| AVR | ADDED | 5,545,984 | 5,382,965 | 3.03% | 54,627,942 |
| COR | ADDED | 173,588 | 100,894 | 72.05% | 49,121,932 |
| MMS | REDUCED | 715,267 | 768,825 | -6.97% | 38,452,754 |
| ALLO | NEW | 13,323,431 | - | - | 27,712,736 |
| GSK | ADDED | 436,700 | 385,879 | 13.17% | 22,891,814 |
| TYRA | ADDED | 695,315 | 605,439 | 14.84% | 22,208,361 |
| IDYA | NEW | 480,383 | - | - | 17,903,874 |
| ORKA | ADDED | 177,118 | 132,496 | 33.68% | 16,856,320 |
| SNY | ADDED | 364,200 | 239,671 | 51.96% | 15,536,772 |
| VTRS | NEW | 954,299 | - | - | 15,154,268 |
| RAPP | REDUCED | 307,657 | 366,809 | -16.13% | 12,820,067 |
| ABT | REDUCED | 128,656 | 186,574 | -31.04% | 11,674,245 |
| CELC | REDUCED | 110,022 | 193,843 | -43.24% | 11,510,502 |
| ZBH | ADDED | 131,445 | 62,613 | 109.93% | 11,316,100 |
| REGN | NEW | 18,000 | - | - | 11,223,720 |
| BMY | NEW | 193,500 | - | - | 11,149,470 |
| MDT | NEW | 142,500 | - | - | 11,147,775 |
| VIR | REDUCED | 1,075,274 | 1,498,620 | -28.25% | 10,957,042 |
| EYPT | REDUCED | 623,130 | 721,785 | -13.67% | 8,910,759 |
| HELP | NEW | 1,300,000 | - | - | 8,593,000 |
| ANIP | REDUCED | 97,305 | 265,543 | -63.36% | 8,054,908 |
| TARA | REDUCED | 1,921,872 | 1,969,839 | -2.44% | 7,341,551 |
| RLMD | ADDED | 1,003,562 | 965,000 | 4.0% | 6,944,649 |
| TNGX | NEW | 208,500 | - | - | 6,517,710 |
| AQST | REDUCED | 1,486,175 | 1,922,887 | -22.71% | 6,182,488 |
| SION | REDUCED | 127,808 | 294,340 | -56.58% | 5,622,274 |
| OCUL | REDUCED | 539,493 | 968,597 | -44.3% | 5,297,821 |
| ZBIO | REDUCED | 208,557 | 331,730 | -37.13% | 5,293,177 |
| DRUG | REDUCED | 73,952 | 86,083 | -14.09% | 5,191,430 |
| OKUR | UNCHANGED | 1,078,965 | 1,078,965 | 0.0% | 4,920,080 |
| SVRA | ADDED | 617,675 | 613,888 | 0.62% | 3,804,878 |
| PMVP | REDUCED | 2,634,137 | 3,076,580 | -14.38% | 3,529,744 |
| OVID | REDUCED | 1,005,334 | 1,252,381 | -19.73% | 2,704,348 |
| IMNM | REDUCED | 124,168 | 165,110 | -24.8% | 2,631,120 |
| HIMS | NEW | 75,000 | - | - | 2,600,250 |
| ANTX | REDUCED | 529,933 | 657,200 | -19.37% | 2,564,876 |
| SER | UNCHANGED | 1,000,000 | 1,000,000 | 0.0% | 1,940,000 |
| ALGS | UNCHANGED | 327,237 | 327,237 | 0.0% | 1,888,157 |
| IBIO | UNCHANGED | 904,268 | 904,268 | 0.0% | 1,582,469 |
| XLO | UNCHANGED | 152,464 | 152,464 | 0.0% | 1,460,605 |
| AORT | NEW | 48,481 | - | - | 1,089,368 |
| TELA | UNCHANGED | 636,300 | 636,300 | 0.0% | 477,225 |
| ENVB | NEW | 180,000 | - | - | 248,400 |
| RCKT | UNCHANGED | 400,000 | 400,000 | 0.0% | 1,480 |
| HUMA | UNCHANGED | 49,998 | 49,998 | 0.0% | 477 |
| PRQR | CLOSED OUT | 0 | 1,954,715 | -100.0% | 0 |
| EMBC | CLOSED OUT | 0 | 1,847,850 | -100.0% | 0 |
| CMPS | CLOSED OUT | 0 | 1,506,525 | -100.0% | 0 |
| BHVN | CLOSED OUT | 0 | 1,163,926 | -100.0% | 0 |
| HYPR | CLOSED OUT | 0 | 1,000,000 | -100.0% | 0 |
| CNTX | CLOSED OUT | 0 | 917,922 | -100.0% | 0 |
| OGN | CLOSED OUT | 0 | 865,908 | -100.0% | 0 |
| REPL | CLOSED OUT | 0 | 720,036 | -100.0% | 0 |
| CORT | CLOSED OUT | 0 | 674,759 | -100.0% | 0 |
| LIVN | CLOSED OUT | 0 | 421,615 | -100.0% | 0 |
| QDEL | CLOSED OUT | 0 | 359,011 | -100.0% | 0 |
| ICLR | CLOSED OUT | 0 | 306,358 | -100.0% | 0 |
| EWTX | CLOSED OUT | 0 | 268,986 | -100.0% | 0 |
| SI | CLOSED OUT | 0 | 210,641 | -100.0% | 0 |
| GPCR | CLOSED OUT | 0 | 209,093 | -100.0% | 0 |
| BMRN | CLOSED OUT | 0 | 194,226 | -100.0% | 0 |
| MNPR | CLOSED OUT | 0 | 173,506 | -100.0% | 0 |
| BOLD | CLOSED OUT | 0 | 163,679 | -100.0% | 0 |
| FHTX | CLOSED OUT | 0 | 122,889 | -100.0% | 0 |
| TFX | CLOSED OUT | 0 | 94,800 | -100.0% | 0 |
| IRON | CLOSED OUT | 0 | 65,203 | -100.0% | 0 |
| ENTA | CLOSED OUT | 0 | 40,000 | -100.0% | 0 |
| KYMR | CLOSED OUT | 0 | 32,235 | -100.0% | 0 |
| ELTX | CLOSED OUT | 0 | 11,700 | -100.0% | 0 |
| ERAS | CLOSED OUT | 0 | 5,000 | -100.0% | 0 |
| OSCR | CLOSED OUT | 0 | 3,000 | -100.0% | 0 |
| SLP | CLOSED OUT | 0 | 200 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| AVR | ADDED | ANTERIS TECHNOLOGIES GLOBAL | COM | 03675P102 | 54,627,942 | 9.04 | 5545984.0 |
| COR | ADDED | CENCORA INC | COM | 03073E105 | 49,121,932 | 8.13 | 173588.0 |
| MMS | REDUCED | MAXIMUS INC | COM | 577933104 | 38,452,754 | 6.36 | 715267.0 |
| ALLO | NEW | ALLOGENE THERAPEUTICS INC | COM | 019770106 | 27,712,736 | 4.59 | 1.3323431E7 |
| - | GLOBUS MED INC | CL A | 379577208 | 23,846,482 | 3.95 | 301816.0 | |
| GSK | ADDED | GSK PLC | SPONSORED ADR | 37733W204 | 22,891,814 | 3.79 | 436700.0 |
| TYRA | ADDED | TYRA BIOSCIENCES INC | COM | 90240B106 | 22,208,361 | 3.68 | 695315.0 |
| - | WAYSTAR HLDG CORP | COM | 946784105 | 19,007,372 | 3.15 | 925834.0 | |
| - | SELLAS LIFE SCIENCES GROUP I | COM NEW | 81642T209 | 18,165,132 | 3.01 | 1230700.0 | |
| IDYA | NEW | IDEAYA BIOSCIENCES INC | COM | 45166A102 | 17,903,874 | 2.96 | 480383.0 |
| ORKA | ADDED | ORUKA THERAPEUTICS INC | COM | 687604108 | 16,856,320 | 2.79 | 177118.0 |
| - | THE CIGNA GROUP | COM | 125523100 | 15,920,520 | 2.63 | 57750.0 | |
| SNY | ADDED | SANOFI SA | SPONSORED ADR | 80105N105 | 15,536,772 | 2.57 | 364200.0 |
| - | ICON PUB LTD CO | SHS | G4705A100 | 15,318,790 | 2.53 | 88186.0 | |
| VTRS | NEW | VIATRIS INC | COM | 92556V106 | 15,154,268 | 2.51 | 954299.0 |
| - | CROSS CTRY HEALTHCARE INC | COM | 227483104 | 14,509,772 | 2.4 | 1098393.0 | |
| RAPP | REDUCED | RAPPORT THERAPEUTICS INC | COM | 75383L102 | 12,820,067 | 2.12 | 307657.0 |
| ABT | REDUCED | ABBOTT LABORATORIES | COM | 002824100 | 11,674,245 | 1.93 | 128656.0 |
| CELC | REDUCED | CELCUITY INC | COM | 15102K100 | 11,510,502 | 1.9 | 110022.0 |
| ZBH | ADDED | ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 11,316,100 | 1.87 | 131445.0 |
| REGN | NEW | REGENERON PHARMACEUTICALS | COM | 75886F107 | 11,223,720 | 1.86 | 18000.0 |
| BMY | NEW | BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 11,149,470 | 1.85 | 193500.0 |
| MDT | NEW | MEDTRONIC PLC | SHS | G5960L103 | 11,147,775 | 1.84 | 142500.0 |
| VIR | REDUCED | VIR BIOTECHNOLOGY INC | COM | 92764N102 | 10,957,042 | 1.81 | 1075274.0 |
| - | SENSEONICS HLDGS INC | COM | 81727U303 | 9,046,491 | 1.5 | 1592692.0 | |
| EYPT | REDUCED | EYEPOINT INC | COM NEW | 30233G209 | 8,910,759 | 1.47 | 623130.0 |
| HELP | NEW | CYBIN INC | COM NEW | 23256X407 | 8,593,000 | 1.42 | 1300000.0 |
| ANIP | REDUCED | ANI PHARMACEUTICALS INC | COM | 00182C103 | 8,054,908 | 1.33 | 97305.0 |
| TARA | REDUCED | PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 7,341,551 | 1.21 | 1921872.0 |
| RLMD | ADDED | RELMADA THERAPEUTICS INC | COM | 75955J402 | 6,944,649 | 1.15 | 1003562.0 |
| TNGX | NEW | TANGO THERAPEUTICS INC | COM | 87583X109 | 6,517,710 | 1.08 | 208500.0 |
| AQST | REDUCED | AQUESTIVE THERAPEUTICS INC | COM | 03843E104 | 6,182,488 | 1.02 | 1486175.0 |
| - | DIANTHUS THERAPEUTICS INC | COM | 252828108 | 5,776,080 | 0.96 | 59254.0 | |
| SION | REDUCED | SIONNA THERAPEUTICS INC | COM | 829401108 | 5,622,274 | 0.93 | 127808.0 |
| OCUL | REDUCED | OCULAR THERAPEUTIX INC | COM | 67576A100 | 5,297,821 | 0.88 | 539493.0 |
| ZBIO | REDUCED | ZENAS BIOPHARMA INC | COM | 98937L105 | 5,293,177 | 0.88 | 208557.0 |
| DRUG | REDUCED | BRIGHT MINDS BIOSCIENCES INC | COM NEW | 10919W405 | 5,191,430 | 0.86 | 73952.0 |
| OKUR | UNCHANGED | ONKURE THERAPEUTICS INC | COM CL A | 68277Q105 | 4,920,080 | 0.81 | 1078965.0 |
| SVRA | ADDED | SAVARA INC | COM | 805111101 | 3,804,878 | 0.63 | 617675.0 |
| PMVP | REDUCED | PMV PHARMACEUTICALS INC | COM | 69353Y103 | 3,529,744 | 0.58 | 2634137.0 |
| - | AVEANNA HEALTHCARE HLDGS INC | COM | 05356F105 | 3,162,639 | 0.52 | 369036.0 | |
| OVID | REDUCED | OVID THERAPEUTICS INC | COM | 690469101 | 2,704,348 | 0.45 | 1005334.0 |
| IMNM | REDUCED | IMMUNOME INC | COM | 45257U108 | 2,631,120 | 0.44 | 124168.0 |
| HIMS | NEW | HIMS & HERS HEALTH INC | COM CL A | 433000106 | 2,600,250 | 0.43 | 75000.0 |
| ANTX | REDUCED | AN2 THERAPEUTICS INC | COM | 037326105 | 2,564,876 | 0.42 | 529933.0 |
| SER | UNCHANGED | SERINA THERAPEUTICS INC | COM SHS | 81751A108 | 1,940,000 | 0.32 | 1000000.0 |
| ALGS | UNCHANGED | ALIGOS THERAPEUTICS INC | COM NEW | 01626L204 | 1,888,157 | 0.31 | 327237.0 |
| IBIO | UNCHANGED | IBIO INC | COM NEW | 451033708 | 1,582,469 | 0.26 | 904268.0 |
| XLO | UNCHANGED | XILIO THERAPEUTICS INC | COM | 98422T209 | 1,460,605 | 0.24 | 152464.0 |
| AORT | NEW | ARTIVION INC | COM | 228903100 | 1,089,368 | 0.18 | 48481.0 |
| - | BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | 107924102 | 995,385 | 0.16 | 130628.0 | |
| TELA | UNCHANGED | TELA BIO INC | COM | 872381108 | 477,225 | 0.08 | 636300.0 |
| - | ADAGIO MED HLDGS INC | COM | 00534B100 | 455,461 | 0.08 | 698989.0 | |
| - | NEUROONE MED TECHNOLOGIES CO | COM | 64130M308 | 251,612 | 0.04 | 82767.0 | |
| ENVB | NEW | ENVERIC BIOSCIENCES INC | COM SHS | 29405E505 | 248,400 | 0.04 | 180000.0 |
| - | MODULAR MED INC | COM NEW | 60785L306 | 117,855 | 0.02 | 26190.0 | |
| - | QT IMAGING HLDGS INC | COM | 746962307 | 62,011 | 0.01 | 15236.0 | |
| RCKT | UNCHANGED | ROCKET PHARMACEUTICALS INC | *W EXP 09/02/202 | 77313F114 | 1,480 | 0.0 | 400000.0 |
| HUMA | UNCHANGED | HUMACYTE INC | *W EXP 08/27/202 | 44486Q111 | 477 | 0.0 | 49998.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 604,294,540 | 59 | 8.749281 | 0.176098 | 28.565762 |
| 2026-03-31 | 2026-05-14 | 697,308,424 | 76 | 7.607959 | 0.169145 | 22.661943 |
| 2025-12-31 | 2026-02-17 | 635,740,442 | 68 | 6.660591 | 0.135965 | 17.958596 |
| 2025-09-30 | 2025-11-13 | 395,154,620 | 51 | 7.301854 | 0.130449 | 21.746833 |
| 2025-03-31 | 2025-05-15 | 335,797,884 | 54 | 8.765933 | 0.260833 | 25.992031 |
| 2024-12-31 | 2025-02-14 | 355,411,105 | 51 | 8.125396 | 0.188194 | 28.772099 |