DAFNA Capital Management LLC
CIK 0001389933
Annualised vol
15.102425%
Beta
0.289428
HHI
609.328801
Top-10 weight
56.209043%
VaR 95%
1.438326%
VaR 99%
2.744613%
Max drawdown
34.789287%
Matched value
91.562976%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| RVMD | REDUCED | 562,630 | 580,678 | -3.11% | 105,369,346 |
| CMPS | REDUCED | 2,011,952 | 2,418,882 | -16.82% | 28,469,121 |
| STXS | UNCHANGED | 13,680,554 | 13,680,554 | 0.0% | 23,530,553 |
| NKTR | ADDED | 318,380 | 165,178 | 92.75% | 22,226,108 |
| DNLI | ADDED | 739,014 | 318,500 | 132.03% | 19,007,440 |
| IDYA | ADDED | 497,240 | 476,740 | 4.3% | 18,532,135 |
| ATRC | UNCHANGED | 597,431 | 597,431 | 0.0% | 16,716,119 |
| XENE | UNCHANGED | 250,772 | 250,772 | 0.0% | 15,136,598 |
| CYTK | REDUCED | 171,998 | 217,497 | -20.92% | 14,652,510 |
| RCUS | REDUCED | 441,829 | 443,829 | -0.45% | 13,621,588 |
| ASND | REDUCED | 48,469 | 4,023,177 | -98.8% | 12,927,652 |
| NBIX | REDUCED | 57,769 | 70,615 | -18.19% | 9,736,098 |
| AXGN | REDUCED | 208,960 | 249,960 | -16.4% | 9,651,862 |
| PODD | ADDED | 61,870 | 10,870 | 469.18% | 9,419,708 |
| EWTX | ADDED | 226,819 | 112,236 | 102.09% | 9,215,656 |
| BCAX | REDUCED | 284,955 | 421,733 | -32.43% | 8,460,314 |
| SNDX | ADDED | 335,255 | 217,355 | 54.24% | 7,328,674 |
| MPLT | UNCHANGED | 171,006 | 171,006 | 0.0% | 6,128,855 |
| LRMR | REDUCED | 2,008,164 | 2,029,164 | -1.03% | 6,124,900 |
| IPSC | REDUCED | 2,400,458 | 2,434,353 | -1.39% | 5,881,122 |
| DXCM | UNCHANGED | 86,279 | 86,279 | 0.0% | 5,810,891 |
| IMVT | REDUCED | 149,524 | 150,524 | -0.66% | 5,761,160 |
| INGN | UNCHANGED | 845,179 | 845,179 | 0.0% | 5,451,405 |
| TNDM | UNCHANGED | 355,208 | 355,208 | 0.0% | 5,360,089 |
| ALKS | REDUCED | 101,266 | 139,482 | -27.4% | 5,305,832 |
| STOK | UNCHANGED | 130,875 | 130,875 | 0.0% | 4,282,230 |
| ALLO | ADDED | 2,000,000 | 1,370,118 | 45.97% | 4,160,000 |
| BCRX | REDUCED | 400,248 | 430,248 | -6.97% | 4,002,480 |
| LKFT | NEW | 130,175 | - | - | 3,902,647 |
| KIDS | ADDED | 189,130 | 95,659 | 97.71% | 3,618,057 |
| HELP | ADDED | 514,061 | 498,361 | 3.15% | 3,397,943 |
| RAPP | UNCHANGED | 75,000 | 75,000 | 0.0% | 3,125,250 |
| KYMR | NEW | 27,000 | - | - | 3,096,090 |
| NGNE | ADDED | 89,032 | 56,635 | 57.2% | 2,800,056 |
| ANL | NEW | 239,553 | - | - | 2,754,860 |
| PRCT | UNCHANGED | 120,000 | 120,000 | 0.0% | 2,709,600 |
| AQST | ADDED | 645,915 | 368,415 | 75.32% | 2,687,006 |
| CLDX | UNCHANGED | 68,518 | 68,518 | 0.0% | 2,549,555 |
| GPCR | UNCHANGED | 46,500 | 46,500 | 0.0% | 2,495,655 |
| ALGN | REDUCED | 14,000 | 15,000 | -6.67% | 2,361,240 |
| VKTX | UNCHANGED | 59,516 | 59,516 | 0.0% | 2,321,719 |
| NGEN | NEW | 1,050,000 | - | - | 2,163,000 |
| BHVN | REDUCED | 137,593 | 845,735 | -83.73% | 2,047,384 |
| MAZE | ADDED | 65,000 | 35,000 | 85.71% | 1,939,600 |
| ALEC | UNCHANGED | 908,351 | 908,351 | 0.0% | 1,825,786 |
| LXEO | UNCHANGED | 377,059 | 377,059 | 0.0% | 1,755,210 |
| PROF | REDUCED | 260,360 | 263,005 | -1.01% | 1,731,394 |
| RNA | NEW | 128,000 | - | - | 1,721,600 |
| ANNX | ADDED | 297,812 | 117,812 | 152.79% | 1,700,507 |
| CTMX | ADDED | 438,407 | 230,000 | 90.61% | 1,644,026 |
| RARE | REDUCED | 47,100 | 61,100 | -22.91% | 1,572,669 |
| EPRX | NEW | 225,600 | - | - | 1,491,216 |
| DSGN | NEW | 102,600 | - | - | 1,484,622 |
| FATE | REDUCED | 525,000 | 550,000 | -4.55% | 1,417,500 |
| MDWD | UNCHANGED | 94,405 | 94,405 | 0.0% | 1,387,754 |
| KURA | REDUCED | 120,568 | 235,868 | -48.88% | 1,322,631 |
| SPRY | ADDED | 164,285 | 139,285 | 17.95% | 1,315,923 |
| MLYS | ADDED | 44,490 | 38,490 | 15.59% | 1,200,340 |
| TELA | UNCHANGED | 1,441,029 | 1,441,029 | 0.0% | 1,080,772 |
| PYPD | UNCHANGED | 207,900 | 207,900 | 0.0% | 1,056,132 |
| INSP | UNCHANGED | 18,200 | 18,200 | 0.0% | 811,902 |
| ACET | UNCHANGED | 93,812 | 93,812 | 0.0% | 810,536 |
| SPTX | NEW | 32,400 | - | - | 703,728 |
| MBX | REDUCED | 11,809 | 175,465 | -93.27% | 651,857 |
| BNTX | UNCHANGED | 7,000 | 7,000 | 0.0% | 651,350 |
| ARTV | NEW | 67,101 | - | - | 650,880 |
| PLRX | UNCHANGED | 487,000 | 487,000 | 0.0% | 555,180 |
| SCYX | REDUCED | 135,868 | 1,086,956 | -87.5% | 552,983 |
| EDIT | NEW | 170,470 | - | - | 552,323 |
| OBIO | UNCHANGED | 126,841 | 126,841 | 0.0% | 547,319 |
| FHTX | UNCHANGED | 111,859 | 111,859 | 0.0% | 545,872 |
| ARAY | UNCHANGED | 1,680,508 | 1,680,508 | 0.0% | 433,235 |
| QTTB | NEW | 32,896 | - | - | 419,095 |
| NVCT | NEW | 20,000 | - | - | 367,800 |
| CGEN | REDUCED | 168,232 | 257,783 | -34.74% | 360,016 |
| IBIO | REDUCED | 170,053 | 193,638 | -12.18% | 297,593 |
| AUTL | UNCHANGED | 179,316 | 179,316 | 0.0% | 286,906 |
| BCYC | UNCHANGED | 64,492 | 64,492 | 0.0% | 273,446 |
| TNYA | NEW | 300,000 | - | - | 221,730 |
| VRCA | REDUCED | 23,750 | 153,712 | -84.55% | 145,350 |
| ENGN | NEW | 74,650 | - | - | 129,145 |
| KARD | NEW | 5,000 | - | - | 119,250 |
| ADCT | ADDED | 77,081 | 72,081 | 6.94% | 82,477 |
| PRQR | CLOSED OUT | 0 | 1,567,561 | -100.0% | 0 |
| FULC | CLOSED OUT | 0 | 205,000 | -100.0% | 0 |
| ORIC | CLOSED OUT | 0 | 98,724 | -100.0% | 0 |
| NMRA | CLOSED OUT | 0 | 70,000 | -100.0% | 0 |
| KPTI | CLOSED OUT | 0 | 45,800 | -100.0% | 0 |
| ZBIO | CLOSED OUT | 0 | 42,500 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| RVMD | REDUCED | REVOLUTION MEDICINES INC | COM | 76155X100 | 105,369,346 | 20.09 | 562630.0 |
| - | SPDR S&P BIOTECH ETF | ETF | 78464A870 | 31,096,916 | 5.93 | 196505.0 | |
| CMPS | REDUCED | COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | 28,469,121 | 5.43 | 2011952.0 |
| STXS | UNCHANGED | STEREOTAXIS INC | COM NEW | 85916J409 | 23,530,553 | 4.49 | 1.3680554E7 |
| NKTR | ADDED | NEKTAR THERAPEUTICS | COM NEW | 640268306 | 22,226,108 | 4.24 | 318380.0 |
| DNLI | ADDED | DENALI THERAPEUTICS INC | COM | 24823R105 | 19,007,440 | 3.62 | 739014.0 |
| IDYA | ADDED | IDEAYA BIOSCIENCES INC | COM | 45166A102 | 18,532,135 | 3.53 | 497240.0 |
| ATRC | UNCHANGED | ATRICURE INC | COM | 04963C209 | 16,716,119 | 3.19 | 597431.0 |
| XENE | UNCHANGED | XENON PHARMACEUTICALS INC | COM | 98420N105 | 15,136,598 | 2.89 | 250772.0 |
| CYTK | REDUCED | CYTOKINETICS INC | COM NEW | 23282W605 | 14,652,510 | 2.79 | 171998.0 |
| RCUS | REDUCED | ARCUS BIOSCIENCES INC | COM | 03969F109 | 13,621,588 | 2.6 | 441829.0 |
| ASND | REDUCED | ASCENDIS PHARMA A/S | ORD SHS | K08588103 | 12,927,652 | 2.47 | 48469.0 |
| NBIX | REDUCED | NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 9,736,098 | 1.86 | 57769.0 |
| AXGN | REDUCED | AXOGEN INC | COM | 05463X106 | 9,651,862 | 1.84 | 208960.0 |
| PODD | ADDED | INSULET CORP | COM | 45784P101 | 9,419,708 | 1.8 | 61870.0 |
| EWTX | ADDED | EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 9,215,656 | 1.76 | 226819.0 |
| BCAX | REDUCED | BICARA THERAPEUTICS INC | COM | 055477103 | 8,460,314 | 1.61 | 284955.0 |
| - | ISHARES NASDAQ BIOTECH INDX | ETF | 464287556 | 8,101,143 | 1.54 | 42595.0 | |
| SNDX | ADDED | SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 7,328,674 | 1.4 | 335255.0 |
| MPLT | UNCHANGED | MAPLIGHT THERAPEUTICS INC | COM | 56565P103 | 6,128,855 | 1.17 | 171006.0 |
| LRMR | REDUCED | LARIMAR THERAPEUTICS INC | COM | 517125100 | 6,124,900 | 1.17 | 2008164.0 |
| IPSC | REDUCED | CENTURY THERAPEUTICS INC | COM | 15673T100 | 5,881,122 | 1.12 | 2400458.0 |
| DXCM | UNCHANGED | DEXCOM INC | COM | 252131107 | 5,810,891 | 1.11 | 86279.0 |
| IMVT | REDUCED | IMMUNOVANT INC | COM | 45258J102 | 5,761,160 | 1.1 | 149524.0 |
| INGN | UNCHANGED | INOGEN INC | COM | 45780L104 | 5,451,405 | 1.04 | 845179.0 |
| TNDM | UNCHANGED | TANDEM DIABETES CARE INC | COM | 875372203 | 5,360,089 | 1.02 | 355208.0 |
| ALKS | REDUCED | ALKERMES PLC | SHS | G01767105 | 5,305,832 | 1.01 | 101266.0 |
| STOK | UNCHANGED | STOKE THERAPEUTICS INC | COM | 86150R107 | 4,282,230 | 0.82 | 130875.0 |
| ALLO | ADDED | ALLOGENE THERAPEUTICS INC | COM | 019770106 | 4,160,000 | 0.79 | 2000000.0 |
| BCRX | REDUCED | BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | 4,002,480 | 0.76 | 400248.0 |
| LKFT | NEW | LAKEFRONT BIOTHERAPEUTICS NV | SPON ADR | 36315X101 | 3,902,647 | 0.74 | 130175.0 |
| KIDS | ADDED | ORTHOPEDIATRICS CORP | COM | 68752L100 | 3,618,057 | 0.69 | 189130.0 |
| HELP | ADDED | CYBIN INC | COM NEW | 23256X407 | 3,397,943 | 0.65 | 514061.0 |
| RAPP | UNCHANGED | RAPPORT THERAPEUTICS INC | COM | 75383L102 | 3,125,250 | 0.6 | 75000.0 |
| KYMR | NEW | KYMERA THERAPEUTICS INC | COM | 501575104 | 3,096,090 | 0.59 | 27000.0 |
| - | PROQR THERAPEUTICS NV | SHS EURO | N71542109 | 2,846,471 | 0.54 | 1530361.0 | |
| NGNE | ADDED | NEUROGENE INC | COM | 64135M105 | 2,800,056 | 0.53 | 89032.0 |
| ANL | NEW | ADLAI NORTYE LTD | SPONSORED ADS | 00704R109 | 2,754,860 | 0.53 | 239553.0 |
| PRCT | UNCHANGED | PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 2,709,600 | 0.52 | 120000.0 |
| AQST | ADDED | AQUESTIVE THERAPEUTICS INC | COM | 03843E104 | 2,687,006 | 0.51 | 645915.0 |
| CLDX | UNCHANGED | CELLDEX THERAPEUTICS INC | COM NEW | 15117B202 | 2,549,555 | 0.49 | 68518.0 |
| GPCR | UNCHANGED | STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 2,495,655 | 0.48 | 46500.0 |
| ALGN | REDUCED | ALIGN TECHNOLOGY INC | COM | 016255101 | 2,361,240 | 0.45 | 14000.0 |
| VKTX | UNCHANGED | VIKING THERAPEUTICS INC | COM | 92686J106 | 2,321,719 | 0.44 | 59516.0 |
| NGEN | NEW | NERVGEN PHARMA CORP | COM | 64082X203 | 2,163,000 | 0.41 | 1050000.0 |
| BHVN | REDUCED | BIOHAVEN LTD | COM | G1110E107 | 2,047,384 | 0.39 | 137593.0 |
| MAZE | ADDED | MAZE THERAPEUTICS INC | COM | 578784100 | 1,939,600 | 0.37 | 65000.0 |
| ALEC | UNCHANGED | ALECTOR INC | COM | 014442107 | 1,825,786 | 0.35 | 908351.0 |
| LXEO | UNCHANGED | LEXEO THERAPEUTICS INC | COM | 52886X107 | 1,755,210 | 0.33 | 377059.0 |
| PROF | REDUCED | PROFOUND MEDICAL CORP | COM NEW | 74319B502 | 1,731,394 | 0.33 | 260360.0 |
| RNA | NEW | ATRIUM THERAPEUTICS INC | COM | 04965N104 | 1,721,600 | 0.33 | 128000.0 |
| ANNX | ADDED | ANNEXON INC | COM | 03589W102 | 1,700,507 | 0.32 | 297812.0 |
| CTMX | ADDED | CYTOMX THERAPEUTICS INC | COM | 23284F105 | 1,644,026 | 0.31 | 438407.0 |
| RARE | REDUCED | ULTRAGENYX PHARMACEUTICAL INC | COM | 90400D108 | 1,572,669 | 0.3 | 47100.0 |
| EPRX | NEW | EUPRAXIA PHARMACEUTICALS INC | COM | 29842P105 | 1,491,216 | 0.28 | 225600.0 |
| DSGN | NEW | DESIGN THERAPEUTICS INC | COM | 25056L103 | 1,484,622 | 0.28 | 102600.0 |
| FATE | REDUCED | FATE THERAPEUTICS INC | COM | 31189P102 | 1,417,500 | 0.27 | 525000.0 |
| MDWD | UNCHANGED | MEDIWOUND LTD | SHS NEW | M68830112 | 1,387,754 | 0.26 | 94405.0 |
| KURA | REDUCED | KURA ONCOLOGY INC | COM | 50127T109 | 1,322,631 | 0.25 | 120568.0 |
| SPRY | ADDED | ARS PHARMACEUTICALS INC | COM | 82835W108 | 1,315,923 | 0.25 | 164285.0 |
| MLYS | ADDED | MINERALYS THERAPEUTICS INC | COM | 603170101 | 1,200,340 | 0.23 | 44490.0 |
| - | IMMATICS NV | SHS | N44445109 | 1,184,805 | 0.23 | 116960.0 | |
| TELA | UNCHANGED | TELA BIO INC | COM | 872381108 | 1,080,772 | 0.21 | 1441029.0 |
| PYPD | UNCHANGED | POLYPID LTD | COM | M8001Q126 | 1,056,132 | 0.2 | 207900.0 |
| - | CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 | 1,010,911 | 0.19 | 107773.0 | |
| INSP | UNCHANGED | INSPIRE MEDICAL SYSTEMS INC | COM | 457730109 | 811,902 | 0.15 | 18200.0 |
| ACET | UNCHANGED | ADICET BIO INC | COM NEW | 007002207 | 810,536 | 0.15 | 93812.0 |
| SPTX | NEW | SEAPORT THERAPEUTICS INC | COMMON STOCK | 81221K108 | 703,728 | 0.13 | 32400.0 |
| MBX | REDUCED | MBX BIOSCIENCES INC | COM | 55287L101 | 651,857 | 0.12 | 11809.0 |
| BNTX | UNCHANGED | BIONTECH SE | SPONSORED ADS | 09075V102 | 651,350 | 0.12 | 7000.0 |
| ARTV | NEW | ARTIVA BIOTHERAPEUTICS INC | COM | 04317A107 | 650,880 | 0.12 | 67101.0 |
| PLRX | UNCHANGED | PLIANT THERAPEUTICS INC | COM | 729139105 | 555,180 | 0.11 | 487000.0 |
| SCYX | REDUCED | SCYNEXIS INC | COM | 811292309 | 552,983 | 0.11 | 135868.0 |
| EDIT | NEW | EDITAS MEDICINE INC | COM | 28106W103 | 552,323 | 0.11 | 170470.0 |
| OBIO | UNCHANGED | ORCHESTRA BIOMED HOLDINGS INC | COM | 68572M106 | 547,319 | 0.1 | 126841.0 |
| FHTX | UNCHANGED | FOGHORN THERAPEUTICS INC | COM | 344174107 | 545,872 | 0.1 | 111859.0 |
| ARAY | UNCHANGED | ACCURAY INC | COM | 004397105 | 433,235 | 0.08 | 1680508.0 |
| QTTB | NEW | Q32 BIO INC | COM | 746964105 | 419,095 | 0.08 | 32896.0 |
| NVCT | NEW | NUVECTIS PHARMA INC | COM | 67080T108 | 367,800 | 0.07 | 20000.0 |
| CGEN | REDUCED | COMPUGEN LTD | ORD | M25722105 | 360,016 | 0.07 | 168232.0 |
| IBIO | REDUCED | IBIO INC | COM NEW | 451033708 | 297,593 | 0.06 | 170053.0 |
| AUTL | UNCHANGED | AUTOLUS THERAPEUTICS LTD | SPON ADS | 05280R100 | 286,906 | 0.05 | 179316.0 |
| BCYC | UNCHANGED | BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | 273,446 | 0.05 | 64492.0 |
| TNYA | NEW | TENAYA THERAPEUTICS INC | COM | 87990A106 | 221,730 | 0.04 | 300000.0 |
| VRCA | REDUCED | VERRICA PHARMACEUTICALS INC | COM SHS | 92511W207 | 145,350 | 0.03 | 23750.0 |
| ENGN | NEW | ENGENE THERAPEUTICS INC | COM | 29286X101 | 129,145 | 0.02 | 74650.0 |
| KARD | NEW | KARDIGAN INC | COM | 485925101 | 119,250 | 0.02 | 5000.0 |
| ADCT | ADDED | ADC THERAPEUTICS SA | SHS | H0036K147 | 82,477 | 0.02 | 77081.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 524,358,409 | 88 | 15.102425 | 0.289428 | 34.789287 |
| 2026-03-31 | 2026-05-15 | 439,591,894 | 83 | 11.333545 | 0.217568 | 30.180443 |
| 2025-12-31 | 2026-02-17 | 430,518,714 | 77 | 10.476883 | 0.201082 | 27.672458 |
| 2025-09-30 | 2025-11-14 | 404,785,884 | 75 | 8.714981 | 0.162259 | 23.084586 |
| 2025-03-31 | 2025-05-15 | 352,661,806 | 83 | 7.881881 | 0.150683 | 18.721367 |
| 2024-12-31 | 2025-02-14 | 393,410,219 | 82 | 8.029919 | 0.154625 | 19.720572 |