Sofinnova Investments, Inc.
CIK 0001631134
Annualised vol
17.909266%
Beta
0.467686
HHI
697.692167
Top-10 weight
57.887803%
VaR 95%
1.673951%
VaR 99%
3.01139%
Max drawdown
28.490462%
Matched value
93.101009%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| NTRA | UNCHANGED | 1,550,280 | 1,550,280 | 0.0% | 420,823,506 |
| VERA | UNCHANGED | 2,793,987 | 2,793,987 | 0.0% | 119,889,982 |
| GMAB | ADDED | 4,045,215 | 752,261 | 437.74% | 111,122,056 |
| JAZZ | REDUCED | 365,341 | 598,327 | -38.94% | 88,036,221 |
| RAPP | UNCHANGED | 1,904,408 | 1,904,408 | 0.0% | 79,356,681 |
| SPTX | NEW | 3,564,871 | - | - | 77,428,998 |
| AVBP | UNCHANGED | 1,696,752 | 1,696,752 | 0.0% | 58,945,164 |
| BIOA | UNCHANGED | 2,293,788 | 2,293,788 | 0.0% | 56,220,744 |
| BMY | REDUCED | 876,970 | 1,988,721 | -55.9% | 50,531,011 |
| SUPN | ADDED | 1,036,328 | 954,309 | 8.59% | 48,199,615 |
| RYTM | REDUCED | 408,027 | 450,096 | -9.35% | 45,303,238 |
| GILD | NEW | 343,100 | - | - | 43,347,254 |
| COGT | REDUCED | 1,035,148 | 2,113,551 | -51.02% | 40,060,228 |
| AXSM | REDUCED | 160,429 | 412,747 | -61.13% | 39,268,206 |
| IMTX | ADDED | 3,669,346 | 3,630,454 | 1.07% | 37,170,475 |
| DYN | ADDED | 1,658,384 | 1,633,897 | 1.5% | 36,832,709 |
| IMNM | ADDED | 1,720,316 | 1,701,904 | 1.08% | 36,453,496 |
| IDYA | REDUCED | 925,119 | 1,131,786 | -18.26% | 34,479,185 |
| ANAB | ADDED | 493,536 | 248,253 | 98.8% | 33,313,680 |
| NKTR | REDUCED | 471,763 | 509,546 | -7.42% | 32,933,775 |
| PHVS | ADDED | 881,299 | 818,328 | 7.7% | 30,475,319 |
| RCUS | ADDED | 945,690 | 923,086 | 2.45% | 29,155,623 |
| INBX | REDUCED | 303,103 | 406,029 | -25.35% | 28,719,009 |
| BMRN | REDUCED | 358,568 | 781,982 | -54.15% | 20,517,261 |
| MANE | ADDED | 148,993 | 73,315 | 103.22% | 18,317,199 |
| ALC | REDUCED | 255,824 | 729,972 | -64.95% | 17,165,790 |
| INSM | REDUCED | 158,398 | 346,075 | -54.23% | 16,888,395 |
| ISRG | NEW | 40,000 | - | - | 15,907,200 |
| EWTX | REDUCED | 380,923 | 386,498 | -1.44% | 15,476,901 |
| EXEL | ADDED | 254,200 | 251,500 | 1.07% | 13,831,022 |
| NRIX | NEW | 524,098 | - | - | 12,714,617 |
| DSGN | NEW | 865,135 | - | - | 12,518,503 |
| DFTX | REDUCED | 255,903 | 344,166 | -25.65% | 12,037,677 |
| TRAX | NEW | 565,199 | - | - | 11,371,804 |
| ABT | NEW | 122,998 | - | - | 11,160,839 |
| IRON | ADDED | 146,239 | 78,320 | 86.72% | 10,695,920 |
| TENX | ADDED | 500,039 | 104,400 | 378.96% | 7,275,567 |
| SION | NEW | 144,432 | - | - | 6,353,564 |
| ABSI | NEW | 337,400 | - | - | 3,910,466 |
| MIRM | UNCHANGED | 27,591 | 27,591 | 0.0% | 3,230,078 |
| JBIO | UNCHANGED | 107,391 | 107,391 | 0.0% | 2,386,228 |
| SVRA | UNCHANGED | 364,763 | 364,763 | 0.0% | 2,246,940 |
| SEPN | UNCHANGED | 47,506 | 47,506 | 0.0% | 1,590,976 |
| OKUR | ADDED | 321,692 | 141,700 | 127.02% | 1,466,916 |
| SGMT | NEW | 166,667 | - | - | 1,288,336 |
| WVE | UNCHANGED | 189,253 | 189,253 | 0.0% | 1,099,560 |
| AKTS | NEW | 32,436 | - | - | 1,045,412 |
| TYRA | REDUCED | 32,267 | 204,015 | -84.18% | 1,030,608 |
| BOLT | UNCHANGED | 137,721 | 137,721 | 0.0% | 530,226 |
| NXTC | UNCHANGED | 222,654 | 222,654 | 0.0% | 356,246 |
| IMA | UNCHANGED | 31,884 | 31,884 | 0.0% | 188,116 |
| HTFL | NEW | 5,079 | - | - | 149,018 |
| RARE | CLOSED OUT | 0 | 3,495,888 | -100.0% | 0 |
| CMPX | CLOSED OUT | 0 | 2,556,161 | -100.0% | 0 |
| REPL | CLOSED OUT | 0 | 1,015,400 | -100.0% | 0 |
| PFE | CLOSED OUT | 0 | 800,000 | -100.0% | 0 |
| ORIC | CLOSED OUT | 0 | 679,578 | -100.0% | 0 |
| CELC | CLOSED OUT | 0 | 666,175 | -100.0% | 0 |
| LQDA | CLOSED OUT | 0 | 500,000 | -100.0% | 0 |
| ROIV | CLOSED OUT | 0 | 477,995 | -100.0% | 0 |
| AZN | CLOSED OUT | 0 | 456,031 | -100.0% | 0 |
| BBIO | CLOSED OUT | 0 | 409,183 | -100.0% | 0 |
| TNGX | CLOSED OUT | 0 | 395,081 | -100.0% | 0 |
| DXCM | CLOSED OUT | 0 | 393,576 | -100.0% | 0 |
| XENE | CLOSED OUT | 0 | 305,216 | -100.0% | 0 |
| UTHR | CLOSED OUT | 0 | 240,370 | -100.0% | 0 |
| BIIB | CLOSED OUT | 0 | 229,521 | -100.0% | 0 |
| AXGN | CLOSED OUT | 0 | 210,665 | -100.0% | 0 |
| CYTK | CLOSED OUT | 0 | 91,791 | -100.0% | 0 |
| ACAD | CLOSED OUT | 0 | 78,551 | -100.0% | 0 |
| PRAX | CLOSED OUT | 0 | 63,680 | -100.0% | 0 |
| PCVX | CLOSED OUT | 0 | 50,600 | -100.0% | 0 |
| SYK | CLOSED OUT | 0 | 44,480 | -100.0% | 0 |
| ZYME | CLOSED OUT | 0 | 1,610 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| NTRA | UNCHANGED | Natera Inc | COM | 632307104 | 420,823,506 | 21.76 | 1550280.0 |
| VERA | UNCHANGED | Vera Therapeutics Inc | CL A | 92337R101 | 119,889,982 | 6.2 | 2793987.0 |
| GMAB | ADDED | Genmab A/S | SPONSORED ADS | 372303206 | 111,122,056 | 5.74 | 4045215.0 |
| JAZZ | REDUCED | Jazz Pharmaceuticals PLC | SHS USD | G50871105 | 88,036,221 | 4.55 | 365341.0 |
| RAPP | UNCHANGED | Rapport Therapeutics Inc | COM | 75383L102 | 79,356,681 | 4.1 | 1904408.0 |
| SPTX | NEW | Seaport Therapeutics Inc | COM | 81221K108 | 77,428,998 | 4.0 | 3564871.0 |
| AVBP | UNCHANGED | Arrivent BioPharma Inc | COM | 04272N102 | 58,945,164 | 3.05 | 1696752.0 |
| - | Ultragenyx Pharmaceutical In | COM | 90400D108 | 57,347,492 | 2.96 | 1717505.0 | |
| BIOA | UNCHANGED | BioAge Labs Inc | COM | 09077V100 | 56,220,744 | 2.91 | 2293788.0 |
| BMY | REDUCED | Bristol-Myers Squibb Co | COM | 110122108 | 50,531,011 | 2.61 | 876970.0 |
| SUPN | ADDED | Supernus Pharmaceuticals | COM | 868459108 | 48,199,615 | 2.49 | 1036328.0 |
| RYTM | REDUCED | Rhythm Pharmaceuticals Inc | COM | 76243J105 | 45,303,238 | 2.34 | 408027.0 |
| GILD | NEW | Gilead Sciences Inc | COM | 375558103 | 43,347,254 | 2.24 | 343100.0 |
| - | United Therapeutics Corp Del | COM | 91307C102 | 41,444,035 | 2.14 | 76489.0 | |
| COGT | REDUCED | Cogent Biosciences Inc | COM | 19240Q201 | 40,060,228 | 2.07 | 1035148.0 |
| AXSM | REDUCED | Axsome Therapeutics Inc. | COM | 05464T104 | 39,268,206 | 2.03 | 160429.0 |
| IMTX | ADDED | Immatics N.V | SHS | N44445109 | 37,170,475 | 1.92 | 3669346.0 |
| DYN | ADDED | Dyne Therapeutics Inc | COM | 26818M108 | 36,832,709 | 1.9 | 1658384.0 |
| IMNM | ADDED | Immunome Inc | COM | 45257U108 | 36,453,496 | 1.88 | 1720316.0 |
| IDYA | REDUCED | IDEAYA Biosciences Inc | COM | 45166A102 | 34,479,185 | 1.78 | 925119.0 |
| ANAB | ADDED | Anaptysbio Inc | COM | 032724106 | 33,313,680 | 1.72 | 493536.0 |
| NKTR | REDUCED | Nektar Therapeutics | COM NEW | 640268306 | 32,933,775 | 1.7 | 471763.0 |
| PHVS | ADDED | Pharvaris N V | COM | N69605108 | 30,475,319 | 1.58 | 881299.0 |
| RCUS | ADDED | Arcus Biosciences Inc | COM | 03969F109 | 29,155,623 | 1.51 | 945690.0 |
| INBX | REDUCED | Inhibrx Biosciences Inc | COM | 45720N103 | 28,719,009 | 1.48 | 303103.0 |
| BMRN | REDUCED | BioMarin Pharmaceutical Inc | COM | 09061G101 | 20,517,261 | 1.06 | 358568.0 |
| MANE | ADDED | Veradermics Inc | COMMON STOCK | 922967104 | 18,317,199 | 0.95 | 148993.0 |
| ALC | REDUCED | Alcon AG | ORD SHS | H01301128 | 17,165,790 | 0.89 | 255824.0 |
| INSM | REDUCED | Insmed Inc | COM PAR $.01 | 457669307 | 16,888,395 | 0.87 | 158398.0 |
| - | Ultragenyx Pharmaceutical In | COM | 90400D108 | 16,695,000 | 0.86 | 500000.0 | |
| ISRG | NEW | Intuitive Surgical Inc | COM NEW | 46120E602 | 15,907,200 | 0.82 | 40000.0 |
| - | Globus Med Inc | CL A | 379577208 | 15,802,000 | 0.82 | 200000.0 | |
| EWTX | REDUCED | Edgewise Therapeutics Inc | COM | 28036F105 | 15,476,901 | 0.8 | 380923.0 |
| EXEL | ADDED | Exelixis Inc | COM | 30161Q104 | 13,831,022 | 0.72 | 254200.0 |
| NRIX | NEW | Nurix Therapeutics Inc | COM | 67080M103 | 12,714,617 | 0.66 | 524098.0 |
| DSGN | NEW | Design Therapeutics Inc | COM | 25056L103 | 12,518,503 | 0.65 | 865135.0 |
| DFTX | REDUCED | Definium Therapeutics Inc | COM SHS | 24477V105 | 12,037,677 | 0.62 | 255903.0 |
| TRAX | NEW | First Tracks Biotherapeutics | ORD SHS | 337185102 | 11,371,804 | 0.59 | 565199.0 |
| ABT | NEW | Abbott Laboratories | COM | 002824100 | 11,160,839 | 0.58 | 122998.0 |
| IRON | ADDED | Disc Medicine Inc | COM | 254604101 | 10,695,920 | 0.55 | 146239.0 |
| TENX | ADDED | Tenax Therapeutics Inc | COM NEW | 88032L605 | 7,275,567 | 0.38 | 500039.0 |
| SION | NEW | Sionna Therapeutics Inc | COM | 829401108 | 6,353,564 | 0.33 | 144432.0 |
| ABSI | NEW | Absci Corporation | COM | 00091E109 | 3,910,466 | 0.2 | 337400.0 |
| MIRM | UNCHANGED | Mirum Pharmaceuticals Inc | COM | 604749101 | 3,230,078 | 0.17 | 27591.0 |
| JBIO | UNCHANGED | Jade Biosciences Inc | COM | 008064206 | 2,386,228 | 0.12 | 107391.0 |
| SVRA | UNCHANGED | Savara Inc | COM | 805111101 | 2,246,940 | 0.12 | 364763.0 |
| - | Praxis Precision Medicines I | COM NEW | 74006W207 | 2,156,048 | 0.11 | 6440.0 | |
| SEPN | UNCHANGED | Septerna Inc | COM | 81734D104 | 1,590,976 | 0.08 | 47506.0 |
| OKUR | ADDED | Onkure Therapeutics Inc | COM CL A | 68277Q105 | 1,466,916 | 0.08 | 321692.0 |
| SGMT | NEW | Sagimet Biosciences Inc | COM SER A | 786700104 | 1,288,336 | 0.07 | 166667.0 |
| WVE | UNCHANGED | Wave Life Sciences Ltd | SHS | Y95308105 | 1,099,560 | 0.06 | 189253.0 |
| AKTS | NEW | Aktis Oncology Inc | COM | 01021M104 | 1,045,412 | 0.05 | 32436.0 |
| TYRA | REDUCED | Tyra Biosciences Inc | COM | 90240B106 | 1,030,608 | 0.05 | 32267.0 |
| BOLT | UNCHANGED | Bolt Biotherapeutics Inc | COM | 097702203 | 530,226 | 0.03 | 137721.0 |
| NXTC | UNCHANGED | Nextcure Inc | COM | 65343E207 | 356,246 | 0.02 | 222654.0 |
| IMA | UNCHANGED | ImageneBio Inc | COM | 45175G207 | 188,116 | 0.01 | 31884.0 |
| HTFL | NEW | Heartflow Inc | COM | 42238D107 | 149,018 | 0.01 | 5079.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 1,934,262,135 | 57 | 17.909266 | 0.467686 | 28.490462 |
| 2026-03-31 | 2026-05-15 | 2,631,154,214 | 75 | 14.617874 | 0.433351 | 24.129104 |
| 2025-12-31 | 2026-02-13 | 2,319,284,145 | 60 | 15.98266 | 0.482643 | 25.155441 |
| 2025-09-30 | 2025-11-14 | 1,828,830,662 | 62 | 15.305085 | 0.485707 | 25.579094 |
| 2025-03-31 | 2025-05-15 | 1,531,129,746 | 65 | 15.260695 | 0.499939 | 23.401802 |
| 2024-12-31 | 2025-02-14 | 1,372,864,097 | 61 | 18.123742 | 0.558886 | 23.891828 |