Opaleye Management Inc.
CIK 0001595855
Annualised vol
10.703427%
Beta
0.11119
HHI
654.575304
Top-10 weight
64.760489%
VaR 95%
0.982419%
VaR 99%
2.064761%
Max drawdown
22.457433%
Matched value
88.395963%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| LQDA | REDUCED | 2,447,500 | 2,545,000 | -3.83% | 195,139,175 |
| ETON | UNCHANGED | 2,860,000 | 2,860,000 | 0.0% | 103,532,000 |
| HROW | REDUCED | 2,400,000 | 2,832,230 | -15.26% | 101,928,000 |
| IRON | ADDED | 855,000 | 421,000 | 103.09% | 62,534,700 |
| URGN | ADDED | 1,439,996 | 1,430,000 | 0.7% | 52,991,853 |
| SLGL | UNCHANGED | 500,000 | 500,000 | 0.0% | 37,070,000 |
| RZLT | UNCHANGED | 6,300,000 | 6,300,000 | 0.0% | 32,760,000 |
| TGTX | UNCHANGED | 535,000 | 535,000 | 0.0% | 29,392,900 |
| IMMX | NEW | 2,345,000 | - | - | 24,176,950 |
| CBIO | ADDED | 1,319,351 | 1,312,615 | 0.51% | 23,748,318 |
| STOK | UNCHANGED | 700,000 | 700,000 | 0.0% | 22,904,000 |
| ACOG | ADDED | 2,895,467 | 2,561,950 | 13.02% | 20,905,272 |
| EWTX | UNCHANGED | 500,000 | 500,000 | 0.0% | 20,315,000 |
| RVMD | UNCHANGED | 100,000 | 100,000 | 0.0% | 18,728,000 |
| GLUE | NEW | 745,000 | - | - | 18,029,000 |
| ALMS | UNCHANGED | 550,000 | 550,000 | 0.0% | 15,477,000 |
| CDXS | UNCHANGED | 6,785,000 | 6,785,000 | 0.0% | 15,334,100 |
| REPL | NEW | 1,384,993 | - | - | 15,331,873 |
| MBX | UNCHANGED | 260,000 | 260,000 | 0.0% | 14,352,000 |
| RYTM | REDUCED | 122,500 | 123,000 | -0.41% | 13,601,175 |
| EDIT | ADDED | 3,861,930 | 1,926,997 | 100.41% | 12,512,653 |
| PTGX | UNCHANGED | 100,000 | 100,000 | 0.0% | 12,258,000 |
| CABA | ADDED | 3,863,800 | 1,380,000 | 179.99% | 12,016,418 |
| QTTB | REDUCED | 931,000 | 1,256,228 | -25.89% | 11,860,940 |
| ANNX | REDUCED | 1,714,451 | 2,331,761 | -26.47% | 9,789,515 |
| VSTM | NEW | 1,800,000 | - | - | 6,876,000 |
| ZNTL | UNCHANGED | 1,412,656 | 1,412,656 | 0.0% | 6,851,382 |
| RLMD | UNCHANGED | 935,000 | 935,000 | 0.0% | 6,470,200 |
| OCUL | UNCHANGED | 600,000 | 600,000 | 0.0% | 5,892,000 |
| TRVI | REDUCED | 310,000 | 345,100 | -10.17% | 5,781,500 |
| LYEL | ADDED | 344,025 | 79,097 | 334.94% | 4,833,551 |
| IRD | ADDED | 1,125,000 | 1,120,000 | 0.45% | 4,623,750 |
| NTLA | ADDED | 250,000 | 245,000 | 2.04% | 4,230,000 |
| VYGR | ADDED | 1,185,000 | 1,150,000 | 3.04% | 4,147,500 |
| BDSX | REDUCED | 180,000 | 238,047 | -24.38% | 4,059,000 |
| RCKT | ADDED | 1,000,000 | 955,000 | 4.71% | 3,420,000 |
| JBIO | REDUCED | 145,000 | 427,608 | -66.09% | 3,221,900 |
| SNWV | REDUCED | 306,140 | 981,267 | -68.8% | 3,061,400 |
| FBIO | REDUCED | 890,000 | 1,042,000 | -14.59% | 2,723,400 |
| PHAT | NEW | 185,589 | - | - | 2,013,641 |
| INBX | NEW | 20,291 | - | - | 1,922,572 |
| ENTA | UNCHANGED | 125,000 | 125,000 | 0.0% | 1,822,500 |
| TRAX | NEW | 65,000 | - | - | 1,307,800 |
| CGON | REDUCED | 17,789 | 94,800 | -81.24% | 1,263,908 |
| BHVN | NEW | 77,915 | - | - | 1,159,375 |
| AVIR | REDUCED | 235,000 | 322,600 | -27.15% | 1,092,750 |
| KTTA | NEW | 2,050,000 | - | - | 1,056,570 |
| ADCT | NEW | 700,000 | - | - | 749,000 |
| OKYO | NEW | 375,204 | - | - | 562,806 |
| PTN | NEW | 20,500 | - | - | 221,195 |
| CATX | CLOSED OUT | 0 | 4,875,000 | -100.0% | 0 |
| PLX | CLOSED OUT | 0 | 340,000 | -100.0% | 0 |
| STRO | CLOSED OUT | 0 | 190,671 | -100.0% | 0 |
| NXTC | CLOSED OUT | 0 | 141,181 | -100.0% | 0 |
| TECX | CLOSED OUT | 0 | 123,000 | -100.0% | 0 |
| RIGL | CLOSED OUT | 0 | 70,000 | -100.0% | 0 |
| LBRX | CLOSED OUT | 0 | 14,506 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| LQDA | REDUCED | LIQUIDIA CORPORATION | COM NEW | 53635D202 | 195,139,175 | 17.67 | 2447500.0 |
| ETON | UNCHANGED | ETON PHARMACEUTICALS INC | COM | 29772L108 | 103,532,000 | 9.38 | 2860000.0 |
| HROW | REDUCED | HARROW INC | COM | 415858109 | 101,928,000 | 9.23 | 2400000.0 |
| IRON | ADDED | DISC MEDICINE INC | COM | 254604101 | 62,534,700 | 5.66 | 855000.0 |
| URGN | ADDED | UROGEN PHARMA LTD | COM | M96088105 | 52,991,853 | 4.8 | 1439996.0 |
| - | APOGEE THERAPEUTICS INC | COM | 03770N101 | 51,764,700 | 4.69 | 390000.0 | |
| - | MEIRAGTX HLDGS PLC | COM | G59665102 | 47,960,500 | 4.34 | 3550000.0 | |
| SLGL | UNCHANGED | SOL-GEL TECHNOLOGIES LTD | SHS NEW | M8694L137 | 37,070,000 | 3.36 | 500000.0 |
| RZLT | UNCHANGED | REZOLUTE INC | COM NEW | 76200L309 | 32,760,000 | 2.97 | 6300000.0 |
| TGTX | UNCHANGED | TG THERAPEUTICS INC | COM | 88322Q108 | 29,392,900 | 2.66 | 535000.0 |
| IMMX | NEW | IMMIX BIOPHARMA INC | COM | 45258H106 | 24,176,950 | 2.19 | 2345000.0 |
| CBIO | ADDED | CRESCENT BIOPHARMA INC. | COM | G2545C104 | 23,748,318 | 2.15 | 1319351.0 |
| STOK | UNCHANGED | STOKE THERAPEUTICS INC | COM | 86150R107 | 22,904,000 | 2.07 | 700000.0 |
| ACOG | ADDED | ALPHA COGNITION INC | COM NEW | 02074J501 | 20,905,272 | 1.89 | 2895467.0 |
| EWTX | UNCHANGED | EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 20,315,000 | 1.84 | 500000.0 |
| RVMD | UNCHANGED | REVOLUTION MEDICINES INC | COM | 76155X100 | 18,728,000 | 1.7 | 100000.0 |
| GLUE | NEW | MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 18,029,000 | 1.63 | 745000.0 |
| ALMS | UNCHANGED | ALUMIS INC | COM | 022307102 | 15,477,000 | 1.4 | 550000.0 |
| CDXS | UNCHANGED | CODEXIS INC | COM | 192005106 | 15,334,100 | 1.39 | 6785000.0 |
| REPL | NEW | REPLIMUNE GROUP INC | COM | 76029N106 | 15,331,873 | 1.39 | 1384993.0 |
| - | XOMA ROYALTY CORPORATION | COM NEW | 98419J206 | 14,380,895 | 1.3 | 338374.0 | |
| MBX | UNCHANGED | MBX BIOSCIENCES INC | COM | 55287L101 | 14,352,000 | 1.3 | 260000.0 |
| RYTM | REDUCED | RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 13,601,175 | 1.23 | 122500.0 |
| EDIT | ADDED | EDITAS MEDICINE INC | COM | 28106W103 | 12,512,653 | 1.13 | 3861930.0 |
| PTGX | UNCHANGED | PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 12,258,000 | 1.11 | 100000.0 |
| CABA | ADDED | CABALETTA BIO INC | COM | 12674W109 | 12,016,418 | 1.09 | 3863800.0 |
| QTTB | REDUCED | Q32 BIO INC | COM | 746964105 | 11,860,940 | 1.07 | 931000.0 |
| ANNX | REDUCED | ANNEXON INC | COM | 03589W102 | 9,789,515 | 0.89 | 1714451.0 |
| VSTM | NEW | VERASTEM INC | COM NEW | 92337C203 | 6,876,000 | 0.62 | 1800000.0 |
| ZNTL | UNCHANGED | ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 | 6,851,382 | 0.62 | 1412656.0 |
| RLMD | UNCHANGED | RELMADA THERAPEUTICS INC | COM | 75955J402 | 6,470,200 | 0.59 | 935000.0 |
| OCUL | UNCHANGED | OCULAR THERAPEUTIX INC | COM | 67576A100 | 5,892,000 | 0.53 | 600000.0 |
| TRVI | REDUCED | TREVI THERAPEUTICS INC | COM | 89532M101 | 5,781,500 | 0.52 | 310000.0 |
| - | BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | 107924102 | 5,334,000 | 0.48 | 700000.0 | |
| LYEL | ADDED | LYELL IMMUNOPHARMA INC | COM NEW | 55083R203 | 4,833,551 | 0.44 | 344025.0 |
| IRD | ADDED | OPUS GENETICS INC | COM | 67577R102 | 4,623,750 | 0.42 | 1125000.0 |
| - | 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 4,448,012 | 0.4 | 334437.0 | |
| NTLA | ADDED | INTELLIA THERAPEUTICS INC | COM | 45826J105 | 4,230,000 | 0.38 | 250000.0 |
| VYGR | ADDED | VOYAGER THERAPEUTICS INC | COM | 92915B106 | 4,147,500 | 0.38 | 1185000.0 |
| BDSX | REDUCED | BIODESIX INC | COM | 09075X207 | 4,059,000 | 0.37 | 180000.0 |
| RCKT | ADDED | ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 3,420,000 | 0.31 | 1000000.0 |
| JBIO | REDUCED | JADE BIOSCIENCES INC | COM NEW | 008064206 | 3,221,900 | 0.29 | 145000.0 |
| SNWV | REDUCED | SANUWAVE HEALTH INC | COM | 80303D305 | 3,061,400 | 0.28 | 306140.0 |
| FBIO | REDUCED | FORTRESS BIOTECH INC | COM NEW | 34960Q307 | 2,723,400 | 0.25 | 890000.0 |
| - | JOURNEY MED CORP | COM | 48115J109 | 2,478,000 | 0.22 | 350000.0 | |
| PHAT | NEW | PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | 2,013,641 | 0.18 | 185589.0 |
| INBX | NEW | INHIBRX BIOSCIENCES INC | COM | 45720N103 | 1,922,572 | 0.17 | 20291.0 |
| ENTA | UNCHANGED | ENANTA PHARMACEUTICALS INC | COM | 29251M106 | 1,822,500 | 0.17 | 125000.0 |
| - | HEMAB THERAPEUTICS HLDGS INC | COM SHS | 423494103 | 1,750,258 | 0.16 | 47652.0 | |
| TRAX | NEW | FIRST TRACKS BIOTHERAPEUTICS | ORD SHS | 337185102 | 1,307,800 | 0.12 | 65000.0 |
| CGON | REDUCED | CG ONCOLOGY INC | COM | 156944100 | 1,263,908 | 0.11 | 17789.0 |
| BHVN | NEW | BIOHAVEN LTD | COM | G1110E107 | 1,159,375 | 0.1 | 77915.0 |
| AVIR | REDUCED | ATEA PHARMACEUTICALS INC | COM | 04683R106 | 1,092,750 | 0.1 | 235000.0 |
| KTTA | NEW | PASITHEA THERAPEUTICS CORP | COM NEW | 70261F202 | 1,056,570 | 0.1 | 2050000.0 |
| ADCT | NEW | ADC THERAPEUTICS SA | SHS | H0036K147 | 749,000 | 0.07 | 700000.0 |
| OKYO | NEW | OKYO PHARMA LTD | SHS NEW | G6724L116 | 562,806 | 0.05 | 375204.0 |
| PTN | NEW | PALATIN TECHNOLOGIES INC | COM NEW | 696077601 | 221,195 | 0.02 | 20500.0 |
| - | ADAGIO MED HLDGS INC | COM | 00534B100 | 13,353 | 0.0 | 18444.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 1,104,182,260 | 58 | 10.703427 | 0.11119 | 22.457433 |
| 2026-03-31 | 2026-05-15 | 759,221,131 | 54 | 9.988653 | 0.097763 | 20.788482 |
| 2025-12-31 | 2026-04-13 | 757,893,709 | 54 | 8.301351 | 0.088944 | 16.730588 |
| 2025-09-30 | 2025-11-14 | 707,320,956 | 43 | 8.913701 | 0.103681 | 15.935103 |
| 2025-03-31 | 2025-05-15 | 449,152,370 | 45 | 9.128178 | 0.088168 | 19.093094 |
| 2024-12-31 | 2025-02-14 | 571,422,527 | 39 | 9.291677 | 0.079921 | 21.679851 |