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SPHERA FUNDS MANAGEMENT LTD.

CIK 0001496201

Annualised vol
9.775969%
Beta
0.235988
HHI
197.170005
Top-10 weight
34.080619%
VaR 95%
0.862728%
VaR 99%
1.749372%
Max drawdown
22.953808%
Matched value
81.396985%

Returns of reported holdings

Loading returns…

Position changes vs prior quarter

What the latest 13F shows bought and sold against the quarter before, by share count.

TickerChangeShares nowShares beforeShare change %Value now ($)
BIIB ADDED 196,626 92,526 112.51% 42,483,014
MLYS ADDED 1,469,971 1,339,971 9.7% 39,659,818
TSEM REDUCED 108,265 145,735 -25.71% 28,218,190
CYTK ADDED 319,987 299,117 6.98% 27,259,693
SNDX ADDED 1,014,606 724,563 40.03% 22,179,287
BMRN ADDED 328,550 139,900 134.85% 18,799,631
BBIO ADDED 245,346 245,246 0.04% 18,273,370
COGT ADDED 459,340 416,340 10.33% 17,776,458
NVMI REDUCED 25,169 53,366 -52.84% 13,665,257
INSM NEW 118,800 - - 12,666,456
MAZE ADDED 417,564 227,343 83.67% 12,460,110
AZN UNCHANGED 62,530 62,530 0.0% 11,856,939
SNY UNCHANGED 269,515 269,515 0.0% 11,497,510
HELP ADDED 1,620,753 987,090 64.2% 10,713,177
LLY REDUCED 8,040 9,040 -11.06% 9,643,417
MDGL ADDED 17,419 9,040 92.69% 9,353,132
TRVI REDUCED 499,029 574,029 -13.07% 9,306,891
ORIC ADDED 852,983 537,628 58.66% 9,237,806
ACAD ADDED 356,534 256,202 39.16% 9,020,310
CLDX REDUCED 240,868 243,575 -1.11% 8,962,698
RYTM NEW 80,400 - - 8,926,812
LRCX NEW 18,470 - - 8,003,605
TNGX REDUCED 254,250 343,563 -26.0% 7,947,855
NVS ADDED 50,000 37,000 35.14% 7,832,904
SEDG REDUCED 4,000,000 4,052,836 -1.3% 7,747,190
VOR ADDED 416,417 321,917 29.36% 7,666,237
ABBV UNCHANGED 30,256 30,256 0.0% 7,613,620
MRK ADDED 58,600 48,600 20.58% 7,530,100
JNJ UNCHANGED 28,831 28,831 0.0% 7,322,209
IDYA NEW 196,408 - - 7,320,126
IMTX ADDED 720,057 696,105 3.44% 7,294,177
NVCT NEW 382,945 - - 7,042,359
PFE ADDED 286,000 186,000 53.76% 6,886,880
XENE REDUCED 105,000 127,000 -17.32% 6,337,800
CLYM ADDED 483,747 419,247 15.38% 6,308,061
ZBIO ADDED 230,834 214,334 7.7% 5,858,567
NVO UNCHANGED 120,677 120,677 0.0% 5,785,255
ELVN REDUCED 112,765 153,265 -26.42% 5,722,824
PRLD ADDED 1,019,832 558,339 82.65% 5,435,705
GSK REDUCED 102,000 122,000 -16.39% 5,346,840
BIOA ADDED 213,671 86,518 146.97% 5,237,076
MSLE ADDED 652,590 489,207 33.4% 5,073,887
PALI ADDED 2,257,106 1,733,471 30.21% 4,717,352
ELDN REDUCED 1,191,187 1,772,131 -32.78% 4,693,277
VST NEW 29,450 - - 4,671,654
TLN NEW 12,135 - - 4,662,995
SVRA ADDED 756,164 739,164 2.3% 4,657,970
IRON ADDED 63,538 53,538 18.68% 4,647,169
DYN ADDED 199,594 160,594 24.28% 4,432,983
RLAY REDUCED 233,836 408,436 -42.75% 4,375,072
AVTX NEW 232,294 - - 4,292,793
PMN UNCHANGED 325,591 325,591 0.0% 4,284,784
BCRX REDUCED 422,051 866,464 -51.29% 4,220,510
RVMD REDUCED 22,400 55,110 -59.35% 4,195,072
CABA NEW 1,329,012 - - 4,133,227
GENB ADDED 245,000 185,000 32.43% 4,133,150
MDWD UNCHANGED 273,192 273,192 0.0% 4,015,922
ACOG REDUCED 545,816 567,616 -3.84% 3,940,792
WVE ADDED 638,272 548,272 16.42% 3,708,360
CRVS REDUCED 244,961 247,961 -1.21% 3,659,717
OVID REDUCED 1,353,000 1,622,828 -16.63% 3,639,570
TENX ADDED 247,800 136,015 82.19% 3,605,490
CTMX ADDED 879,000 220,000 299.55% 3,296,250
ALNY NEW 10,800 - - 3,251,124
KURA REDUCED 295,039 295,522 -0.16% 3,236,578
KOD REDUCED 81,796 114,796 -28.75% 3,186,772
ORA REDUCED 28,015 68,250 -58.95% 3,050,834
CTNM ADDED 183,475 173,475 5.76% 3,007,155
LRMR NEW 926,004 - - 2,824,312
IMMX NEW 270,000 - - 2,783,700
AMGN UNCHANGED 7,500 7,500 0.0% 2,715,900
BHVN REDUCED 164,437 594,000 -72.32% 2,446,823
CEG NEW 9,850 - - 2,446,445
VSTM ADDED 632,632 343,678 84.08% 2,416,654
TSHA NEW 250,000 - - 1,702,500
GPCR REDUCED 28,600 50,800 -43.7% 1,534,962
UPB REDUCED 219,700 358,000 -38.63% 1,520,324
VYGR REDUCED 427,554 469,761 -8.98% 1,496,439
IKT NEW 649,309 - - 1,318,097
CRIS REDUCED 98,996 1,994,937 -95.04% 1,033,717
STTK REDUCED 86,461 280,786 -69.21% 600,039
TRAX NEW 27,876 - - 560,865
SKYE UNCHANGED 678,928 678,928 0.0% 470,701
TRAW NEW 398,486 - - 336,043
EVMN REDUCED 22,632 78,234 -71.07% 300,779
HOWL UNCHANGED 626,810 626,810 0.0% 225,589
APRE UNCHANGED 270,000 270,000 0.0% 216,621
CLBT CLOSED OUT 0 631,521 -100.0% 0
ENPH CLOSED OUT 0 142,419 -100.0% 0
OLMA CLOSED OUT 0 100,000 -100.0% 0
AAOI CLOSED OUT 0 73,400 -100.0% 0
IBIT CLOSED OUT 0 59,505 -100.0% 0
CAMT CLOSED OUT 0 53,020 -100.0% 0
PANW CLOSED OUT 0 52,800 -100.0% 0
DTIL CLOSED OUT 0 40,000 -100.0% 0
AMZN CLOSED OUT 0 31,940 -100.0% 0
BMY CLOSED OUT 0 17,500 -100.0% 0
FHTX CLOSED OUT 0 12,224 -100.0% 0
ASND CLOSED OUT 0 8,000 -100.0% 0
NICE CLOSED OUT 0 5,611 -100.0% 0

Holdings (latest quarter)

TickerChangeIssuerClassCUSIPValue ($)Weight %Shares
- TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 47,773,578 6.23 1410082.0
MLYS ADDED MINERALYS THERAPEUTICS INC COM 603170101 39,659,818 5.17 1469971.0
TSEM REDUCED TOWER SEMICONDUCTOR LTD SHS NEW M87915274 28,218,190 3.68 108265.0
- SPDR SERIES TRUST ST STR SP BIOT 78464A870 23,737,500 3.1 150000.0
SNDX ADDED SYNDAX PHARMACEUTICALS INC COM 87164F105 22,179,287 2.89 1014606.0
BIIB ADDED BIOGEN INC COM 09062X103 21,606,000 2.82 100000.0
BIIB ADDED BIOGEN INC COM 09062X103 20,877,014 2.72 96626.0
- ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 19,649,815 2.56 588494.0
BMRN ADDED BIOMARIN PHARMACEUTICAL INC COM 09061G101 18,799,631 2.45 328550.0
CYTK ADDED CYTOKINETICS INC COM NEW 23282W605 18,740,693 2.44 219987.0
BBIO ADDED BRIDGEBIO PHARMA INC COM 10806X102 18,273,370 2.38 245346.0
COGT ADDED COGENT BIOSCIENCES INC COM 19240Q201 17,776,458 2.32 459340.0
NVMI REDUCED NOVA LTD COM M7516K103 13,665,257 1.78 25169.0
INSM NEW INSMED INC COM PAR $.01 457669307 12,666,456 1.65 118800.0
MAZE ADDED MAZE THERAPEUTICS INC COM 578784100 12,460,110 1.63 417564.0
AZN UNCHANGED ASTRAZENECA PLC ORD G0593M107 11,856,939 1.55 62530.0
SNY UNCHANGED SANOFI SA SPONSORED ADR 80105N105 11,497,510 1.5 269515.0
HELP ADDED CYBIN INC COM NEW 23256X407 10,713,177 1.4 1620753.0
LLY REDUCED ELI LILLY & CO COM 532457108 9,643,417 1.26 8040.0
MDGL ADDED MADRIGAL PHARMACEUTICALS INC COM 558868105 9,353,132 1.22 17419.0
TRVI REDUCED TREVI THERAPEUTICS INC COM 89532M101 9,306,891 1.21 499029.0
ACAD ADDED ACADIA PHARMACEUTICALS INC COM 004225108 9,020,310 1.18 356534.0
CLDX REDUCED CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 8,962,698 1.17 240868.0
RYTM NEW RHYTHM PHARMACEUTICALS INC COM 76243J105 8,926,812 1.16 80400.0
CYTK ADDED CYTOKINETICS INC COM NEW 23282W605 8,519,000 1.11 100000.0
ORIC ADDED ORIC PHARMACEUTICALS INC COM 68622P109 8,154,806 1.06 752983.0
LRCX NEW LAM RESEARCH CORP COM NEW 512807306 8,003,605 1.04 18470.0
- APPLIED MATLS INC COM 038222105 7,981,920 1.04 11040.0
TNGX REDUCED TANGO THERAPEUTICS INC COM 87583X109 7,947,855 1.04 254250.0
NVS ADDED NOVARTIS AG SPONSORED ADR 66987V109 7,832,904 1.02 50000.0
SEDG REDUCED SOLAREDGE TECHNOLOGIES INC NOTE 2.250% 7/0 83417MAE4 7,747,190 1.01 4000000.0
VOR ADDED VOR BIOPHARMA INC COM NEW 929033207 7,666,237 1.0 416417.0
ABBV UNCHANGED ABBVIE INC COM 00287Y109 7,613,620 0.99 30256.0
MRK ADDED MERCK & CO INC COM 58933Y105 7,530,100 0.98 58600.0
JNJ UNCHANGED JOHNSON & JOHNSON COM 478160104 7,322,209 0.96 28831.0
IDYA NEW IDEAYA BIOSCIENCES INC COM 45166A102 7,320,126 0.95 196408.0
IMTX ADDED IMMATICS N.V SHS N44445109 7,294,177 0.95 720057.0
NVCT NEW NUVECTIS PHARMA INC COM 67080T108 7,042,359 0.92 382945.0
PFE ADDED PFIZER INC COM 717081103 6,886,880 0.9 286000.0
- HARMONY BIOSCIENCES HLDGS IN COM 413197104 6,432,300 0.84 176663.0
XENE REDUCED XENON PHARMACEUTICALS INC COM 98420N105 6,337,800 0.83 105000.0
CLYM ADDED CLIMB BIO INC COM 28658R106 6,308,061 0.82 483747.0
ZBIO ADDED ZENAS BIOPHARMA INC COM 98937L105 5,858,567 0.76 230834.0
NVO UNCHANGED NOVO-NORDISK A S ADR 670100205 5,785,255 0.75 120677.0
ELVN REDUCED ENLIVEN THERAPEUTICS INC COM 29337E102 5,722,824 0.75 112765.0
PRLD ADDED PRELUDE THERAPEUTICS INC COM 74065P101 5,435,705 0.71 1019832.0
GSK REDUCED GSK PLC SPONSORED ADR 37733W204 5,346,840 0.7 102000.0
- FORTE BIOSCIENCES INC COM NEW 34962G208 5,305,976 0.69 249693.0
BIOA ADDED BIOAGE LABS INC COM 09077V100 5,237,076 0.68 213671.0
- SCHOLAR ROCK HLDG CORP COM 80706P103 5,184,575 0.68 94265.0
MSLE ADDED SATELLOS BIOSCIENCE INC COM 80401L803 5,073,887 0.66 652590.0
PALI ADDED PALISADE BIO INC COM 696389402 4,717,352 0.62 2257106.0
ELDN REDUCED ELEDON PHARMACEUTICALS INC COM 28617K101 4,693,277 0.61 1191187.0
VST NEW VISTRA CORP COM 92840M102 4,671,654 0.61 29450.0
TLN NEW TALEN ENERGY CORP COM 87422Q109 4,662,995 0.61 12135.0
SVRA ADDED SAVARA INC COM 805111101 4,657,970 0.61 756164.0
IRON ADDED DISC MEDICINE INC COM 254604101 4,647,169 0.61 63538.0
- GLOBAL X FDS CLOUD COMPUTNG 37954Y442 4,454,766 0.58 195900.0
DYN ADDED DYNE THERAPEUTICS INC COM 26818M108 4,432,983 0.58 199594.0
RLAY REDUCED RELAY THERAPEUTICS INC COM 75943R102 4,375,072 0.57 233836.0
AVTX NEW AVALO THERAPEUTICS INC COM NEW 05338F306 4,292,793 0.56 232294.0
PMN UNCHANGED PROMIS NEUROSCIENCES INC COM SHS 74346M505 4,284,784 0.56 325591.0
BCRX REDUCED BIOCRYST PHARMACEUTICALS INC COM 09058V103 4,220,510 0.55 422051.0
RVMD REDUCED REVOLUTION MEDICINES INC COM 76155X100 4,195,072 0.55 22400.0
- PRAXIS PRECISION MEDICINES I COM NEW 74006W207 4,184,875 0.55 12500.0
CABA NEW CABALETTA BIO INC COM 12674W109 4,133,227 0.54 1329012.0
GENB ADDED GENERATE BIOMEDICINES INC COM SHS 370920100 4,133,150 0.54 245000.0
- ISHARES TR 20 YR TR BD ETF 464287432 4,061,740 0.53 47000.0
MDWD UNCHANGED MEDIWOUND LTD SHS NEW M68830112 4,015,922 0.52 273192.0
ACOG REDUCED ALPHA COGNITION INC COM NEW 02074J501 3,940,792 0.51 545816.0
WVE ADDED WAVE LIFE SCIENCES LTD SHS Y95308105 3,708,360 0.48 638272.0
CRVS REDUCED CORVUS PHARMACEUTICALS INC COM 221015100 3,659,717 0.48 244961.0
OVID REDUCED OVID THERAPEUTICS INC COM 690469101 3,639,570 0.47 1353000.0
- BRIDGEBIO ONCOLOGY THERAPEUT COM NEW 107924102 3,512,706 0.46 460985.0
CTMX ADDED CYTOMX THERAPEUTICS INC. COM 23284F105 3,296,250 0.43 879000.0
- PROQR THRAPEUTICS N V SHS EURO N71542109 3,268,872 0.43 1757458.0
ALNY NEW ALNYLAM PHARMACEUTICALS INC COM 02043Q107 3,251,124 0.42 10800.0
KURA REDUCED KURA ONCOLOGY INC COM 50127T109 3,236,578 0.42 295039.0
KOD REDUCED KODIAK SCIENCES INC COM 50015M109 3,186,772 0.42 81796.0
ORA REDUCED ORMAT TECHNOLOGIES INC COM 686688102 3,050,834 0.4 28015.0
- TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 3,049,200 0.4 90000.0
CTNM ADDED CONTINEUM THERAPEUTICS INC CL A 21217B100 3,007,155 0.39 183475.0
LRMR NEW LARIMAR THERAPEUTICS INC COM 517125100 2,824,312 0.37 926004.0
IMMX NEW IMMIX BIOPHARMA INC COM 45258H106 2,783,700 0.36 270000.0
AMGN UNCHANGED AMGEN INC COM 031162100 2,715,900 0.35 7500.0
- ABIVAX SA SPONSORED ADS 00370M103 2,665,200 0.35 20000.0
BHVN REDUCED BIOHAVEN LTD COM G1110E107 2,446,823 0.32 164437.0
CEG NEW CONSTELLATION ENERGY CORP COM 21037T109 2,446,445 0.32 9850.0
VSTM ADDED VERASTEM INC COM NEW 92337C203 2,416,654 0.32 632632.0
TENX ADDED TENAX THERAPEUTICS INC COM NEW 88032L605 1,856,580 0.24 127600.0
TENX ADDED TENAX THERAPEUTICS INC COM NEW 88032L605 1,748,910 0.23 120200.0
TSHA NEW TAYSHA GENE THERAPIES INC COM SHS 877619106 1,702,500 0.22 250000.0
GPCR REDUCED STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 1,534,962 0.2 28600.0
UPB REDUCED UPSTREAM BIO INC COM 91678A107 1,520,324 0.2 219700.0
VYGR REDUCED VOYAGER THERAPEUTICS INC COM 92915B106 1,496,439 0.2 427554.0
- ORGANOGENESIS HLDGS INC COM 68621F102 1,336,500 0.17 550000.0
IKT NEW INHIBIKASE THERAPEUTICS INC COM NEW 45719W205 1,318,097 0.17 649309.0
ORIC ADDED ORIC PHARMACEUTICALS INC COM 68622P109 1,083,000 0.14 100000.0
CRIS REDUCED CURIS INC COM 231269309 1,033,717 0.13 98996.0
STTK REDUCED SHATTUCK LABS INC COM 82024L103 600,039 0.08 86461.0
TRAX NEW FIRST TRACKS BIOTHERAPEUTICS ORD SHS 337185102 560,865 0.07 27876.0
SKYE UNCHANGED SKYE BIOSCIENCE INC COM NEW 83086J200 470,701 0.06 678928.0
TRAW NEW TRAWS PHARMA INC COM NEW 68232V884 336,043 0.04 398486.0
EVMN REDUCED EVOMMUNE INC COM SHS 30054Y107 300,779 0.04 22632.0
HOWL UNCHANGED WEREWOLF THERAPEUTICS INC COM 95075A107 225,589 0.03 626810.0
APRE UNCHANGED APREA THERAPEUTICS INC COM NEW 03836J201 216,621 0.03 270000.0

Quarterly portfolios

PeriodFiledValue ($)PositionsVol %BetaMax DD %
2026-06-30 2026-08-14 766,539,858 106 9.775969 0.235988 22.953808
2026-03-31 2026-05-15 629,683,422 97 9.40791 0.227011 19.687645
2025-12-31 2026-02-17 517,294,385 100 8.933442 0.207887 22.911645
2025-09-30 2025-11-14 474,069,298 115 7.112988 0.179224 17.068217
2025-03-31 2025-05-15 434,313,987 116 7.87018 0.254346 19.930265
2024-12-31 2025-02-14 553,148,198 108 9.007707 0.314409 20.988994