SECTORAL ASSET MANAGEMENT INC
CIK 0001274413
Annualised vol
8.992423%
Beta
0.281247
HHI
273.677901
Top-10 weight
39.646439%
VaR 95%
0.841083%
VaR 99%
1.485315%
Max drawdown
15.0296%
Matched value
83.640195%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| CTNM | UNCHANGED | 727,587 | 727,587 | 0.0% | 11,925,151 |
| SI | UNCHANGED | 430,407 | 430,407 | 0.0% | 8,728,654 |
| LLY | UNCHANGED | 6,354 | 6,354 | 0.0% | 7,621,178 |
| JNJ | UNCHANGED | 18,218 | 18,218 | 0.0% | 4,626,825 |
| ORKA | NEW | 41,987 | - | - | 3,995,903 |
| BNTX | ADDED | 41,869 | 22,164 | 88.91% | 3,895,910 |
| DFTX | NEW | 78,310 | - | - | 3,683,702 |
| DXCM | ADDED | 50,756 | 23,231 | 118.48% | 3,418,417 |
| RCUS | ADDED | 110,870 | 45,070 | 146.0% | 3,418,122 |
| AMGN | UNCHANGED | 9,210 | 9,210 | 0.0% | 3,335,125 |
| SMMT | ADDED | 220,180 | 69,615 | 216.28% | 3,208,023 |
| IRTC | NEW | 26,070 | - | - | 3,101,027 |
| ABBV | UNCHANGED | 12,200 | 12,200 | 0.0% | 3,070,008 |
| MRK | UNCHANGED | 21,480 | 21,480 | 0.0% | 2,772,981 |
| AVBP | ADDED | 79,043 | 30,013 | 163.36% | 2,745,954 |
| ARGX | REDUCED | 2,831 | 3,564 | -20.57% | 2,626,517 |
| GILD | REDUCED | 20,620 | 27,490 | -24.99% | 2,605,131 |
| INSM | ADDED | 23,216 | 19,668 | 18.04% | 2,475,290 |
| TECX | ADDED | 71,009 | 19,059 | 272.57% | 2,440,934 |
| SYK | ADDED | 7,129 | 5,874 | 21.37% | 2,248,893 |
| AVTX | NEW | 119,923 | - | - | 2,216,177 |
| CBIO | NEW | 121,300 | - | - | 2,183,400 |
| ROIV | ADDED | 61,100 | 32,500 | 88.0% | 2,162,329 |
| IQV | ADDED | 10,848 | 8,307 | 30.59% | 2,096,051 |
| PLSE | NEW | 67,895 | - | - | 1,882,728 |
| TMO | UNCHANGED | 3,508 | 3,508 | 0.0% | 1,759,926 |
| BSX | ADDED | 36,330 | 34,780 | 4.46% | 1,550,564 |
| TMDX | NEW | 21,950 | - | - | 1,457,919 |
| CYTK | ADDED | 16,330 | 7,300 | 123.7% | 1,391,153 |
| CVS | NEW | 13,000 | - | - | 1,344,850 |
| EW | REDUCED | 14,826 | 17,338 | -14.49% | 1,341,160 |
| TRVI | REDUCED | 65,596 | 74,446 | -11.89% | 1,223,365 |
| BMY | UNCHANGED | 21,150 | 21,150 | 0.0% | 1,218,663 |
| VERA | UNCHANGED | 25,573 | 25,573 | 0.0% | 1,097,337 |
| COGT | ADDED | 26,740 | 22,140 | 20.78% | 1,034,838 |
| MDT | UNCHANGED | 11,100 | 11,100 | 0.0% | 876,345 |
| TARS | ADDED | 13,285 | 11,272 | 17.86% | 836,158 |
| KURA | UNCHANGED | 71,480 | 71,480 | 0.0% | 784,136 |
| UTHR | REDUCED | 1,370 | 1,710 | -19.88% | 742,307 |
| HNGE | REDUCED | 8,744 | 12,244 | -28.59% | 725,752 |
| NKTR | REDUCED | 10,111 | 10,851 | -6.82% | 705,849 |
| ASND | REDUCED | 2,570 | 2,800 | -8.21% | 685,470 |
| PFE | UNCHANGED | 27,500 | 27,500 | 0.0% | 662,200 |
| ARDX | UNCHANGED | 122,394 | 122,394 | 0.0% | 624,209 |
| PRVA | REDUCED | 24,136 | 27,136 | -11.06% | 621,019 |
| PTCT | ADDED | 7,470 | 6,650 | 12.33% | 609,328 |
| AGMB | UNCHANGED | 43,500 | 43,500 | 0.0% | 564,630 |
| ONC | UNCHANGED | 1,870 | 1,870 | 0.0% | 532,894 |
| HUM | NEW | 1,250 | - | - | 497,299 |
| RPRX | UNCHANGED | 7,200 | 7,200 | 0.0% | 403,704 |
| BIIB | UNCHANGED | 1,850 | 1,850 | 0.0% | 399,711 |
| MLYS | REDUCED | 14,565 | 31,618 | -53.93% | 392,964 |
| ILMN | UNCHANGED | 2,132 | 2,132 | 0.0% | 374,870 |
| RVMD | UNCHANGED | 1,830 | 1,830 | 0.0% | 342,722 |
| BBIO | REDUCED | 4,100 | 8,100 | -49.38% | 305,368 |
| MRNA | UNCHANGED | 4,350 | 4,350 | 0.0% | 304,631 |
| GH | UNCHANGED | 1,980 | 1,980 | 0.0% | 297,059 |
| INCY | UNCHANGED | 2,350 | 2,350 | 0.0% | 266,396 |
| ORIC | UNCHANGED | 23,500 | 23,500 | 0.0% | 254,505 |
| SPRY | REDUCED | 29,900 | 79,150 | -62.22% | 239,499 |
| GPCR | REDUCED | 4,325 | 14,102 | -69.33% | 232,123 |
| MEDP | UNCHANGED | 430 | 430 | 0.0% | 227,724 |
| TEM | NEW | 3,880 | - | - | 224,768 |
| PALI | UNCHANGED | 88,000 | 88,000 | 0.0% | 183,920 |
| ENGN | NEW | 21,700 | - | - | 37,541 |
| BOLD | CLOSED OUT | 0 | 678,574 | -100.0% | 0 |
| EVMN | CLOSED OUT | 0 | 589,005 | -100.0% | 0 |
| QURE | CLOSED OUT | 0 | 29,245 | -100.0% | 0 |
| OMDA | CLOSED OUT | 0 | 25,620 | -100.0% | 0 |
| RAPP | CLOSED OUT | 0 | 25,421 | -100.0% | 0 |
| RDNT | CLOSED OUT | 0 | 7,999 | -100.0% | 0 |
| NBIX | CLOSED OUT | 0 | 2,300 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| CTNM | UNCHANGED | CONTINEUM THERAPEUTICS | CL A | 21217B100 | 11,925,151 | 8.32 | 727587.0 |
| SI | UNCHANGED | SHOULDER INNOVATIONS | COMMON STOCK | 82537J108 | 8,728,654 | 6.09 | 430407.0 |
| LLY | UNCHANGED | ELI LILLY & CO | COM | 532457108 | 7,621,178 | 5.32 | 6354.0 |
| - | UNITEDHEALTH GRP INC | COM | 91324P102 | 5,500,863 | 3.84 | 13235.0 | |
| JNJ | UNCHANGED | JOHNSON & JOHNSON | COM | 478160104 | 4,626,825 | 3.23 | 18218.0 |
| ORKA | NEW | ORUKA THERAPEUTICS INC | COM | 687604108 | 3,995,903 | 2.79 | 41987.0 |
| BNTX | ADDED | BIONTECH SE | SP ADR | 09075V102 | 3,895,910 | 2.72 | 41869.0 |
| DFTX | NEW | DEFINIUM THERAPEUTICS INC | COM SHS | 24477V105 | 3,683,702 | 2.57 | 78310.0 |
| DXCM | ADDED | DEXCOM INC | COM | 252131107 | 3,418,417 | 2.39 | 50756.0 |
| RCUS | ADDED | ARCUS BIOSCIENCES | COM | 03969F109 | 3,418,122 | 2.39 | 110870.0 |
| AMGN | UNCHANGED | AMGEN INC | COM | 031162100 | 3,335,125 | 2.33 | 9210.0 |
| SMMT | ADDED | SUMMIT THERAPEUTICS | COM | 86627T108 | 3,208,023 | 2.24 | 220180.0 |
| IRTC | NEW | IRHYTHM HOLDINGS INC | COM | 450056106 | 3,101,027 | 2.16 | 26070.0 |
| ABBV | UNCHANGED | ABBVIE INC | COM | 00287Y109 | 3,070,008 | 2.14 | 12200.0 |
| MRK | UNCHANGED | MERCK & CO INC | COM | 58933Y105 | 2,772,981 | 1.94 | 21480.0 |
| AVBP | ADDED | ARRIVENT BIOPHARMA | COM | 04272N102 | 2,745,954 | 1.92 | 79043.0 |
| - | VERTEX PHARMA | COM | 92532F100 | 2,698,237 | 1.88 | 5432.0 | |
| ARGX | REDUCED | ARGENX SE | SP ADR | 04016X101 | 2,626,517 | 1.83 | 2831.0 |
| GILD | REDUCED | GILEAD SCIENCES INC | COM | 375558103 | 2,605,131 | 1.82 | 20620.0 |
| INSM | ADDED | INSMED INC | COM PAR $.01 | 457669307 | 2,475,290 | 1.73 | 23216.0 |
| TECX | ADDED | TECTONIC THERAPEUTIC | COM | 878972108 | 2,440,934 | 1.7 | 71009.0 |
| - | INTUITIVE SURGIC INC | COM NEW | 46120E602 | 2,326,428 | 1.62 | 5850.0 | |
| - | IMMATICS NV | SHS | N44445109 | 2,278,521 | 1.59 | 224928.0 | |
| SYK | ADDED | STRYKER CORP | COM | 863667101 | 2,248,893 | 1.57 | 7129.0 |
| AVTX | NEW | AVALO THERAPEUTICS INC | COM NEW | 05338F306 | 2,216,177 | 1.55 | 119923.0 |
| CBIO | NEW | CRESCENT BIOPHARMA INC. | COM | G2545C104 | 2,183,400 | 1.52 | 121300.0 |
| ROIV | ADDED | ROIVANT SCIENCES LTD | SHS | G76279101 | 2,162,329 | 1.51 | 61100.0 |
| IQV | ADDED | IQVIA HOLDINGS INC | COM | 46266C105 | 2,096,051 | 1.46 | 10848.0 |
| PLSE | NEW | PULSE BIOSCIENCES INC | COM | 74587B101 | 1,882,728 | 1.31 | 67895.0 |
| - | DANAHER CORP | COM | 235851102 | 1,830,726 | 1.28 | 9597.0 | |
| TMO | UNCHANGED | THERMO FISHER SCIENTIFIC | COM | 883556102 | 1,759,926 | 1.23 | 3508.0 |
| - | ABBOTT LABS | COM | 002824100 | 1,640,579 | 1.14 | 18080.0 | |
| - | ALPHATEC HLDGS INC | COM NEW | 02081G201 | 1,608,035 | 1.12 | 185900.0 | |
| BSX | ADDED | BOSTON SCIENTIFIC | COM | 101137107 | 1,550,564 | 1.08 | 36330.0 |
| TMDX | NEW | TRANSMEDICS GROUP INC | COM | 89377M109 | 1,457,919 | 1.02 | 21950.0 |
| CYTK | ADDED | CYTOKINETICS INC | COM NEW | 23282W605 | 1,391,153 | 0.97 | 16330.0 |
| - | REGENERON PHARMCTCLS | COM | 75886F107 | 1,352,458 | 0.94 | 2169.0 | |
| CVS | NEW | CVS HEALTH CORP | COM | 126650100 | 1,344,850 | 0.94 | 13000.0 |
| EW | REDUCED | EDWARDS LIFESCIENCES | COM | 28176E108 | 1,341,160 | 0.94 | 14826.0 |
| TRVI | REDUCED | TREVI THERAPEUTICS | COM | 89532M101 | 1,223,365 | 0.85 | 65596.0 |
| BMY | UNCHANGED | BRISTOL MYERS SQUIBB | COM | 110122108 | 1,218,663 | 0.85 | 21150.0 |
| VERA | UNCHANGED | VERA THERAPEUTICS | CL A | 92337R101 | 1,097,337 | 0.77 | 25573.0 |
| COGT | ADDED | COGENT BIOSCIENCES | COM | 19240Q201 | 1,034,838 | 0.72 | 26740.0 |
| MDT | UNCHANGED | MEDTRONIC PLC | SHS | G5960L103 | 876,345 | 0.61 | 11100.0 |
| TARS | ADDED | TARSUS PHARMACEUTICALS | COM | 87650L103 | 836,158 | 0.58 | 13285.0 |
| KURA | UNCHANGED | KURA ONCOLOGY INC | COM | 50127T109 | 784,136 | 0.55 | 71480.0 |
| - | CENTENE CORP DEL | COM | 15135B101 | 770,280 | 0.54 | 12000.0 | |
| UTHR | REDUCED | UNITED THERAPEUTICS | COM | 91307C102 | 742,307 | 0.52 | 1370.0 |
| HNGE | REDUCED | HINGE HEALTH INC | CL A | 433313103 | 725,752 | 0.51 | 8744.0 |
| NKTR | REDUCED | NEKTAR THERAPEUTICS | COM NEW | 640268306 | 705,849 | 0.49 | 10111.0 |
| - | ALNYLAM PHARMACUETCL | COM | 02043Q107 | 695,379 | 0.49 | 2310.0 | |
| ASND | REDUCED | ASCENDIS PHARMA A/S | ORD SHS | K08588103 | 685,470 | 0.48 | 2570.0 |
| PFE | UNCHANGED | PFIZER INC | COM | 717081103 | 662,200 | 0.46 | 27500.0 |
| ARDX | UNCHANGED | ARDELYX INC | COM | 039697107 | 624,209 | 0.44 | 122394.0 |
| PRVA | REDUCED | PRIVIA HEALTH GROUP | COM | 74276R102 | 621,019 | 0.43 | 24136.0 |
| PTCT | ADDED | PTC THERAPEUTICS INC | COM | 69366J200 | 609,328 | 0.43 | 7470.0 |
| - | IONIS PHARMACEUTICAL | COM | 462222100 | 570,888 | 0.4 | 7200.0 | |
| AGMB | UNCHANGED | AGOMAB THERAPEUTICS | SPONSORED ADS | 00860C102 | 564,630 | 0.39 | 43500.0 |
| - | BIOMARIN PHARMAC | COM | 09061G101 | 540,729 | 0.38 | 9450.0 | |
| ONC | UNCHANGED | BEONE MEDICINES LTD | SP ADR | 07725L102 | 532,894 | 0.37 | 1870.0 |
| HUM | NEW | HUMANA INC | INC | 444859102 | 497,299 | 0.35 | 1250.0 |
| - | JAZZ PHARMA PLC | SHS USD | G50871105 | 421,698 | 0.29 | 1750.0 | |
| RPRX | UNCHANGED | ROYALTY PHARMA PLC | SHS CLASS A | G7709Q104 | 403,704 | 0.28 | 7200.0 |
| BIIB | UNCHANGED | BIOGEN INC | COM | 09062X103 | 399,711 | 0.28 | 1850.0 |
| MLYS | REDUCED | MINERALYS THERAPEUTICS | COM | 603170101 | 392,964 | 0.27 | 14565.0 |
| ILMN | UNCHANGED | ILLUMINA INC | COM | 452327109 | 374,870 | 0.26 | 2132.0 |
| - | AXSOME THERAPEUTIC | COM | 05464T104 | 367,155 | 0.26 | 1500.0 | |
| - | SYNDAX PHARMACEUTICS | COM | 87164F105 | 342,765 | 0.24 | 15680.0 | |
| RVMD | UNCHANGED | REVOLUTION MEDICINES | COM | 76155X100 | 342,722 | 0.24 | 1830.0 |
| - | ABIVAX SA | SPONSORED ADS | 00370M103 | 311,828 | 0.22 | 2340.0 | |
| BBIO | REDUCED | BRIDGEBIO PHARMA | COM | 10806X102 | 305,368 | 0.21 | 4100.0 |
| MRNA | UNCHANGED | MODERNA INC | COM | 60770K107 | 304,631 | 0.21 | 4350.0 |
| GH | UNCHANGED | GUARDANT HEALTH INC | COM | 40131M109 | 297,059 | 0.21 | 1980.0 |
| INCY | UNCHANGED | INCYTE CORPORATION | COM | 45337C102 | 266,396 | 0.19 | 2350.0 |
| ORIC | UNCHANGED | ORIC PHARMACEUTICALS | COM | 68622P109 | 254,505 | 0.18 | 23500.0 |
| SPRY | REDUCED | ARS PHARMACEUTICALS | COM | 82835W108 | 239,499 | 0.17 | 29900.0 |
| GPCR | REDUCED | STRUCTURE THERAPEUTICS | SP ADR | 86366E106 | 232,123 | 0.16 | 4325.0 |
| MEDP | UNCHANGED | MEDPACE HOLDINGS | COM | 58506Q109 | 227,724 | 0.16 | 430.0 |
| TEM | NEW | TEMPUS AI INC | CL A | 88023B103 | 224,768 | 0.16 | 3880.0 |
| - | ORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 | 187,600 | 0.13 | 20000.0 | |
| PALI | UNCHANGED | PALISADE BIO INC | COM | 696389402 | 183,920 | 0.13 | 88000.0 |
| ENGN | NEW | ENGENE THERAPEUTICS INC | COM | 29286X101 | 37,541 | 0.03 | 21700.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 143,303,475 | 82 | 8.992423 | 0.281247 | 15.0296 |
| 2026-03-31 | 2026-05-15 | 120,727,538 | 77 | 8.736182 | 0.274669 | 9.73362 |
| 2025-12-31 | 2026-02-09 | 124,752,405 | 74 | 8.086725 | 0.257139 | 9.751809 |
| 2025-09-30 | 2025-11-14 | 162,014,983 | 82 | 7.786403 | 0.19303 | 17.885484 |
| 2025-03-31 | 2025-05-15 | 128,479,667 | 84 | 11.8232 | 0.36107 | 18.552742 |
| 2024-12-31 | 2025-02-14 | 149,822,806 | 86 | 9.154759 | 0.229158 | 16.559202 |