SR One Capital Management, LP
CIK 0001910264
Annualised vol
11.459638%
Beta
0.066476
HHI
1398.587397
Top-10 weight
95.10775%
VaR 95%
0.903549%
VaR 99%
2.084218%
Max drawdown
21.255707%
Matched value
99.875496%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| MANE | UNCHANGED | 2,401,868 | 2,401,868 | 0.0% | 295,285,652 |
| ZBIO | UNCHANGED | 5,037,854 | 5,037,854 | 0.0% | 127,860,735 |
| CRSP | UNCHANGED | 2,038,763 | 2,038,763 | 0.0% | 111,194,134 |
| AVLN | NEW | 3,308,649 | - | - | 108,920,725 |
| DSGN | UNCHANGED | 6,526,476 | 6,526,476 | 0.0% | 94,438,108 |
| ODTX | NEW | 3,794,883 | - | - | 71,002,261 |
| ALMS | UNCHANGED | 1,959,896 | 1,959,896 | 0.0% | 55,151,473 |
| ORIC | ADDED | 4,615,384 | 4,514,929 | 2.22% | 49,984,609 |
| MLYS | UNCHANGED | 1,563,966 | 1,563,966 | 0.0% | 42,195,803 |
| SPRY | UNCHANGED | 4,012,903 | 4,012,903 | 0.0% | 32,143,353 |
| MOBI | NEW | 1,986,072 | - | - | 26,613,365 |
| NKTX | UNCHANGED | 3,333,333 | 3,333,333 | 0.0% | 9,433,332 |
| OCS | UNCHANGED | 641,022 | 641,022 | 0.0% | 8,890,975 |
| RARE | UNCHANGED | 137,753 | 137,753 | 0.0% | 4,599,573 |
| ORKA | CLOSED OUT | 0 | 430,330 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| MANE | UNCHANGED | Veradermics, Inc. | Common Stock | 922967104 | 295,285,652 | 28.42 | 2401868.0 |
| ZBIO | UNCHANGED | Zenas BioPharma, Inc | Common Stock | 98937L105 | 127,860,735 | 12.31 | 5037854.0 |
| CRSP | UNCHANGED | CRISPR Therapeutics AG | Common Shares | H17182108 | 111,194,134 | 10.7 | 2038763.0 |
| AVLN | NEW | Avalyn Pharma, Inc | Common Stock | 05348Y105 | 108,920,725 | 10.48 | 3308649.0 |
| DSGN | UNCHANGED | Design Therapeutics, Inc. | Common Stock | 25056L103 | 94,438,108 | 9.09 | 6526476.0 |
| ODTX | NEW | Odyssey Therapeutics, Inc. | Common Stock | 67613T104 | 71,002,261 | 6.83 | 3794883.0 |
| ALMS | UNCHANGED | Alumis Inc. | Common Stock | 022307102 | 55,151,473 | 5.31 | 1959896.0 |
| ORIC | ADDED | ORIC Pharmaceuticals, Inc. | Common Stock | 68622P109 | 49,984,609 | 4.81 | 4615384.0 |
| MLYS | UNCHANGED | Mineralys Therapeutics Inc. | Common Stock | 603170101 | 42,195,803 | 4.06 | 1563966.0 |
| SPRY | UNCHANGED | ARS Pharmaceuticals, Inc. | Common Stock | 82835W108 | 32,143,353 | 3.09 | 4012903.0 |
| MOBI | NEW | Mobia Medical, Inc | Common Stock | 60705V103 | 26,613,365 | 2.56 | 1986072.0 |
| NKTX | UNCHANGED | Nkarta, Inc. | Common Stock | 65487U108 | 9,433,332 | 0.91 | 3333333.0 |
| OCS | UNCHANGED | Oculis Holding AG | Ordinary Shares | H5870P102 | 8,890,975 | 0.86 | 641022.0 |
| RARE | UNCHANGED | Ultragenyx Pharmaceutical Inc. | Common Stock | 90400D108 | 4,599,573 | 0.44 | 137753.0 |
| - | enGene Holdings Inc. | Common Shares | 29286M105 | 1,293,607 | 0.12 | 747750.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-12 | 1,039,007,705 | 15 | 11.459638 | 0.066476 | 21.255707 |
| 2026-03-31 | 2026-05-14 | 915,442,498 | 14 | 9.783394 | 0.066982 | 21.622126 |
| 2025-12-31 | 2026-02-12 | 706,376,583 | 13 | 15.759615 | 0.102484 | 34.64695 |
| 2025-09-30 | 2025-11-12 | 691,412,158 | 12 | 12.788396 | 0.090864 | 27.74579 |
| 2025-03-31 | 2025-05-13 | 389,283,283 | 12 | 10.444581 | 0.071986 | 24.263828 |
| 2024-12-31 | 2025-02-13 | 410,084,894 | 11 | 9.134205 | 0.063355 | 22.270639 |