Stonepine Capital Management, LLC
CIK 0001440771
Annualised vol
9.703727%
Beta
0.174536
HHI
293.094601
Top-10 weight
44.390058%
VaR 95%
0.890189%
VaR 99%
1.960194%
Max drawdown
15.711041%
Matched value
91.610004%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| EOLS | REDUCED | 2,010,162 | 2,179,091 | -7.75% | 14,185,724 |
| ADMA | REDUCED | 1,390,000 | 1,890,000 | -26.46% | 14,143,800 |
| VSTM | ADDED | 3,349,627 | 3,302,300 | 1.43% | 12,795,575 |
| TENX | REDUCED | 660,000 | 975,200 | -32.32% | 9,603,000 |
| NKTR | ADDED | 120,654 | 85,000 | 41.95% | 8,422,856 |
| CAMP | UNCHANGED | 1,389,622 | 1,389,622 | 0.0% | 6,072,648 |
| INSM | NEW | 40,000 | - | - | 5,600,000 |
| ELOX | NEW | 397,160 | - | - | 5,512,581 |
| KZIA | UNCHANGED | 345,179 | 345,179 | 0.0% | 4,860,120 |
| MDT | NEW | 50,000 | - | - | 4,375,000 |
| INDV | NEW | 100,000 | - | - | 4,103,000 |
| ABT | NEW | 40,000 | - | - | 3,800,000 |
| MSLE | ADDED | 491,624 | 100,000 | 391.62% | 3,723,291 |
| ZVRA | REDUCED | 258,701 | 480,000 | -46.1% | 3,709,772 |
| ABEO | REDUCED | 557,284 | 846,587 | -34.17% | 3,444,015 |
| BSX | NEW | 50,000 | - | - | 3,250,000 |
| EDSA | ADDED | 456,439 | 30,000 | 1421.46% | 3,190,807 |
| BMRN | NEW | 50,000 | - | - | 3,125,000 |
| CABA | ADDED | 917,100 | 50,000 | 1734.2% | 2,852,181 |
| ANTX | REDUCED | 551,692 | 713,845 | -22.72% | 2,670,190 |
| XLO | ADDED | 225,994 | 64,162 | 252.22% | 2,165,023 |
| ACET | ADDED | 245,518 | 221,955 | 10.62% | 2,121,276 |
| XERS | REDUCED | 280,000 | 320,030 | -12.51% | 2,100,000 |
| TELA | ADDED | 2,662,427 | 2,617,252 | 1.73% | 1,996,820 |
| AYTU | ADDED | 912,921 | 792,289 | 15.23% | 1,962,780 |
| CRIS | REDUCED | 3,312,185 | 3,726,406 | -11.12% | 1,729,292 |
| SPRB | NEW | 28,795 | - | - | 1,554,930 |
| SIBN | REDUCED | 100,000 | 114,964 | -13.02% | 1,500,000 |
| OKYO | ADDED | 862,996 | 850,000 | 1.53% | 1,294,494 |
| NMRA | REDUCED | 500,000 | 600,000 | -16.67% | 1,250,000 |
| KTTA | ADDED | 2,201,468 | 831,301 | 164.82% | 1,134,637 |
| SLGL | REDUCED | 14,469 | 27,778 | -47.91% | 1,072,732 |
| LUNG | ADDED | 815,436 | 768,288 | 6.14% | 1,060,067 |
| XFOR | REDUCED | 224,989 | 335,309 | -32.9% | 1,050,699 |
| ARDX | UNCHANGED | 150,000 | 150,000 | 0.0% | 1,050,000 |
| INAB | ADDED | 695,287 | 663,412 | 4.8% | 980,355 |
| MLTX | NEW | 50,000 | - | - | 973,500 |
| QNRX | ADDED | 199,486 | 53,460 | 273.15% | 965,512 |
| MXCT | REDUCED | 751,606 | 1,004,673 | -25.19% | 924,475 |
| PHAT | ADDED | 85,010 | 50,010 | 69.99% | 922,358 |
| AZTR | NEW | 5,285,476 | - | - | 886,903 |
| HELP | REDUCED | 129,280 | 134,060 | -3.57% | 854,541 |
| IKT | REDUCED | 396,179 | 957,202 | -58.61% | 804,243 |
| ZNTL | REDUCED | 161,583 | 269,100 | -39.95% | 783,678 |
| CTMX | REDUCED | 205,000 | 400,000 | -48.75% | 768,750 |
| MNKD | REDUCED | 250,000 | 516,300 | -51.58% | 750,000 |
| NVCT | NEW | 40,000 | - | - | 735,600 |
| CBIO | REDUCED | 40,000 | 85,000 | -52.94% | 720,000 |
| PMVP | REDUCED | 536,086 | 708,102 | -24.29% | 718,355 |
| ORKA | NEW | 7,500 | - | - | 713,775 |
| RADX | UNCHANGED | 51,000,000 | 51,000,000 | 0.0% | 670,500 |
| OKUR | REDUCED | 130,684 | 132,578 | -1.43% | 595,919 |
| NGEN | NEW | 271,678 | - | - | 559,657 |
| CALC | NEW | 622,432 | - | - | 544,939 |
| ARVN | ADDED | 60,000 | 27,500 | 118.18% | 498,600 |
| BIOA | REDUCED | 20,000 | 50,000 | -60.0% | 490,200 |
| IRD | ADDED | 100,718 | 68,688 | 46.63% | 413,951 |
| BOLD | REDUCED | 154,595 | 597,682 | -74.13% | 386,488 |
| SINT | NEW | 209,205 | - | - | 332,531 |
| CLRB | NEW | 104,550 | - | - | 290,649 |
| EPRX | NEW | 43,491 | - | - | 287,476 |
| SABS | ADDED | 73,271 | 50,000 | 46.54% | 285,757 |
| ANL | NEW | 24,257 | - | - | 278,956 |
| PLRX | ADDED | 230,538 | 224,650 | 2.62% | 262,813 |
| CDXS | REDUCED | 109,662 | 417,994 | -73.76% | 247,836 |
| UPB | REDUCED | 33,432 | 35,000 | -4.48% | 231,349 |
| RNTX | NEW | 218,038 | - | - | 226,760 |
| CNSP | REDUCED | 41,573 | 61,000 | -31.85% | 198,719 |
| HUMA | NEW | 231,299 | - | - | 180,506 |
| KLRS | ADDED | 30,122 | 20,400 | 47.66% | 122,597 |
| PCSA | UNCHANGED | 55,000 | 55,000 | 0.0% | 105,600 |
| BCAB | REDUCED | 16,432 | 65,387 | -74.87% | 68,028 |
| CGEN | REDUCED | 31,387 | 104,300 | -69.91% | 67,168 |
| OVID | REDUCED | 21,300 | 40,000 | -46.75% | 57,297 |
| OABI | CLOSED OUT | 0 | 164,045 | -100.0% | 0 |
| CADL | CLOSED OUT | 0 | 102,500 | -100.0% | 0 |
| ACAD | CLOSED OUT | 0 | 100,000 | -100.0% | 0 |
| VRCA | CLOSED OUT | 0 | 99,735 | -100.0% | 0 |
| ELDN | CLOSED OUT | 0 | 35,000 | -100.0% | 0 |
| JANX | CLOSED OUT | 0 | 20,000 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| VSTM | ADDED | VERASTEM INC | COM NEW | 92337C203 | 12,795,575 | 7.22 | 3349627.0 |
| EOLS | REDUCED | EVOLUS INC | COM | 30052C107 | 11,035,724 | 6.23 | 1590162.0 |
| TENX | REDUCED | TENAX THERAPEUTICS INC | COM NEW | 88032L605 | 9,603,000 | 5.42 | 660000.0 |
| NKTR | ADDED | NEKTAR THERAPEUTICS | COM NEW | 640268306 | 8,422,856 | 4.75 | 120654.0 |
| ADMA | REDUCED | ADMA BIOLOGICS INC | COM | 000899104 | 7,950,000 | 4.48 | 650000.0 |
| ADMA | REDUCED | ADMA BIOLOGICS INC | COM | 000899104 | 6,193,800 | 3.49 | 740000.0 |
| CAMP | UNCHANGED | CAMP4 THERAPEUTICS CORP | COM 13469V AB 4 CAMTEK LTD NOTE 12/0 | 13463J101 | 6,072,648 | 3.43 | 1389622.0 |
| INSM | NEW | INSMED INC | COM PAR $.01 | 457669307 | 5,600,000 | 3.16 | 40000.0 |
| ELOX | NEW | ELOXX PHARMACEUTICALS INC | COM NEW | 29014R301 | 5,512,581 | 3.11 | 397160.0 |
| - | ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 5,500,000 | 3.1 | 200000.0 | |
| KZIA | UNCHANGED | KAZIA THERAPEUTICS LTD | SPONSORED ADS | 48669G303 | 4,860,120 | 2.74 | 345179.0 |
| MDT | NEW | MEDTRONIC PLC | SHS | G5960L103 | 4,375,000 | 2.47 | 50000.0 |
| INDV | NEW | INDIVIOR PHARMACEUTICALS INC | COM | 45579U109 | 4,103,000 | 2.31 | 100000.0 |
| - | CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 | 3,986,500 | 2.25 | 425000.0 | |
| ABT | NEW | ABBOTT LABORATORIES | COM | 002824100 | 3,800,000 | 2.14 | 40000.0 |
| MSLE | ADDED | SATELLOS BIOSCIENCE INC | COM | 80401L803 | 3,723,291 | 2.1 | 491624.0 |
| ZVRA | REDUCED | ZEVRA THERAPEUTICS INC | COM NEW | 488445206 | 3,709,772 | 2.09 | 258701.0 |
| ABEO | REDUCED | ABEONA THERAPEUTICS INC | COM NEW | 00289Y206 | 3,444,015 | 1.94 | 557284.0 |
| BSX | NEW | BOSTON SCIENTIFIC CORP | COM | 101137107 | 3,250,000 | 1.83 | 50000.0 |
| EDSA | ADDED | EDESA BIOTECH INC | COM NEW | 27966L306 | 3,190,807 | 1.8 | 456439.0 |
| EOLS | REDUCED | EVOLUS INC | COM | 30052C107 | 3,150,000 | 1.78 | 420000.0 |
| BMRN | NEW | BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 3,125,000 | 1.76 | 50000.0 |
| CABA | ADDED | CABALETTA BIO INC | COM | 12674W109 | 2,852,181 | 1.61 | 917100.0 |
| ANTX | REDUCED | AN2 THERAPEUTICS INC | COM | 037326105 | 2,670,190 | 1.51 | 551692.0 |
| XLO | ADDED | XILIO THERAPEUTICS INC | COM | 98422T209 | 2,165,023 | 1.22 | 225994.0 |
| ACET | ADDED | ADICET BIO INC | COM NEW | 007002207 | 2,121,276 | 1.2 | 245518.0 |
| XERS | REDUCED | XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 | 2,100,000 | 1.18 | 280000.0 |
| TELA | ADDED | TELA BIO INC | COM | 872381108 | 1,996,820 | 1.13 | 2662427.0 |
| AYTU | ADDED | AYTU BIOPHARMA INC | COM | 054754858 | 1,962,780 | 1.11 | 912921.0 |
| CRIS | REDUCED | CURIS INC | COM | 231269309 | 1,729,292 | 0.98 | 3312185.0 |
| SPRB | NEW | SPRUCE BIOSCIENCES INC | COM NEW | 85209E208 | 1,554,930 | 0.88 | 28795.0 |
| - | HERON THERAPEUTICS INC | COM | 427746102 | 1,500,000 | 0.85 | 1000000.0 | |
| SIBN | REDUCED | SI BONE INC | COM | 825704109 | 1,500,000 | 0.85 | 100000.0 |
| OKYO | ADDED | OKYO PHARMA LTD | SHS NEW | G6724L116 | 1,294,494 | 0.73 | 862996.0 |
| NMRA | REDUCED | NEUMORA THERAPEUTICS INC. | COM | 640979100 | 1,250,000 | 0.71 | 500000.0 |
| KTTA | ADDED | PASITHEA THERAPEUTICS CORP | COM NEW | 70261F202 | 1,134,637 | 0.64 | 2201468.0 |
| SLGL | REDUCED | SOL-GEL TECHNOLOGIES LTD | SHS NEW | M8694L137 | 1,072,732 | 0.61 | 14469.0 |
| LUNG | ADDED | PULMONX CORP | COM | 745848101 | 1,060,067 | 0.6 | 815436.0 |
| XFOR | REDUCED | X4 PHARMACEUTICALS INC | COM NEW | 98420X202 | 1,050,699 | 0.59 | 224989.0 |
| ARDX | UNCHANGED | ARDELYX INC | COM | 039697107 | 1,050,000 | 0.59 | 150000.0 |
| - | DELCATH SYS INC | COM NEW | 24661P807 | 1,000,000 | 0.56 | 100000.0 | |
| INAB | ADDED | IN8BIO INC | COM NEW | 45674E208 | 980,355 | 0.55 | 695287.0 |
| MLTX | NEW | MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 973,500 | 0.55 | 50000.0 |
| QNRX | ADDED | QUOIN PHARMACEUTICALS LTD | SPONSORED ADS | 74907L409 | 965,512 | 0.54 | 199486.0 |
| MXCT | REDUCED | MAXCYTE INC | COM | 57777K106 | 924,475 | 0.52 | 751606.0 |
| PHAT | ADDED | PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | 922,358 | 0.52 | 85010.0 |
| AZTR | NEW | AZITRA INC | COM NEW | 05479L302 | 886,903 | 0.5 | 5285476.0 |
| - | CONNECT BIOPHARMA HLDGS LTD | SHS | G23549101 | 866,925 | 0.49 | 364254.0 | |
| HELP | REDUCED | CYBIN INC | COM NEW | 23256X407 | 854,541 | 0.48 | 129280.0 |
| - | ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 834,750 | 0.47 | 25000.0 | |
| IKT | REDUCED | INHIBIKASE THERAPEUTICS INC | COM NEW | 45719W205 | 804,243 | 0.45 | 396179.0 |
| ZNTL | REDUCED | ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 | 783,678 | 0.44 | 161583.0 |
| CTMX | REDUCED | CYTOMX THERAPEUTICS INC. | COM | 23284F105 | 768,750 | 0.43 | 205000.0 |
| MNKD | REDUCED | MANNKIND CORP | COM NEW | 56400P706 | 750,000 | 0.42 | 250000.0 |
| NVCT | NEW | NUVECTIS PHARMA INC | COM | 67080T108 | 735,600 | 0.41 | 40000.0 |
| CBIO | REDUCED | CRESCENT BIOPHARMA INC. | COM | G2545C104 | 720,000 | 0.41 | 40000.0 |
| PMVP | REDUCED | PMV PHARMACEUTICALS INC | COM | 69353Y103 | 718,355 | 0.41 | 536086.0 |
| ORKA | NEW | ORUKA THERAPEUTICS INC | COM | 687604108 | 713,775 | 0.4 | 7500.0 |
| RADX | UNCHANGED | RADIOPHARM THERANOSTICS LTD | SPONSORED ADS | 75041J101 | 670,500 | 0.38 | 5.1E7 |
| OKUR | REDUCED | ONKURE THERAPEUTICS INC | COM CL A | 68277Q105 | 595,919 | 0.34 | 130684.0 |
| NGEN | NEW | NERVGEN PHARMA CORP | COM | 64082X203 | 559,657 | 0.32 | 271678.0 |
| CALC | NEW | CALCIMEDICA INC | COM NEW | 38942Q202 | 544,939 | 0.31 | 622432.0 |
| ARVN | ADDED | ARVINAS INC | COM | 04335A105 | 498,600 | 0.28 | 60000.0 |
| BIOA | REDUCED | BIOAGE LABS INC | COM | 09077V100 | 490,200 | 0.28 | 20000.0 |
| IRD | ADDED | OPUS GENETICS INC | COM | 67577R102 | 413,951 | 0.23 | 100718.0 |
| - | QT IMAGING HLDGS INC | COM | 746962307 | 407,000 | 0.23 | 100000.0 | |
| BOLD | REDUCED | BOUNDLESS BIO INC | COM | 10170A100 | 386,488 | 0.22 | 154595.0 |
| SINT | NEW | SINTX TECHNOLOGIES INC | COM NEW | 829392703 | 332,531 | 0.19 | 209205.0 |
| CLRB | NEW | CELLECTAR BIOSCIENCES INC | COM NEW | 15117F880 | 290,649 | 0.16 | 104550.0 |
| EPRX | NEW | EUPRAXIA PHARMACEUTICALS INC | COM 298736 AL 3 EURONET WORLDWIDE INC NOTE 0.750% | 29842P105 | 287,476 | 0.16 | 43491.0 |
| SABS | ADDED | SAB BIOTHERAPEUTICS INC | COM NEW | 78397T202 | 285,757 | 0.16 | 73271.0 |
| ANL | NEW | ADLAI NORTYE LTD | SPONSORED ADS | 00704R109 | 278,956 | 0.16 | 24257.0 |
| - | SENSEONICS HLDGS INC | COM | 81727U303 | 276,502 | 0.16 | 48680.0 | |
| PLRX | ADDED | PLIANT THERAPEUTICS INC | COM | 729139105 | 262,813 | 0.15 | 230538.0 |
| CDXS | REDUCED | CODEXIS INC | COM | 192005106 | 247,836 | 0.14 | 109662.0 |
| - | PRECISION OPTICS CORP INC MA | COM NEW | 740294400 | 236,589 | 0.13 | 46390.0 | |
| UPB | REDUCED | UPSTREAM BIO INC | COM | 91678A107 | 231,349 | 0.13 | 33432.0 |
| RNTX | NEW | REIN THERAPEUTICS INC | COM NEW | 00887A204 | 226,760 | 0.13 | 218038.0 |
| - | HERON THERAPEUTICS INC | COM | 427746102 | 209,468 | 0.12 | 490787.0 | |
| CNSP | REDUCED | CNS PHARMACEUTICALS INC | COM | 18978H508 | 198,719 | 0.11 | 41573.0 |
| HUMA | NEW | HUMACYTE INC | COM | 44486Q103 | 180,506 | 0.1 | 231299.0 |
| KLRS | ADDED | KALARIS THERAPEUTICS INC | COM | 482929106 | 122,597 | 0.07 | 30122.0 |
| PCSA | UNCHANGED | PROCESSA PHARMACEUTICALS INC | COM SHS | 74275C403 | 105,600 | 0.06 | 55000.0 |
| BCAB | REDUCED | BIOATLA INC | COM NEW | 09077B203 | 68,028 | 0.04 | 16432.0 |
| CGEN | REDUCED | COMPUGEN LTD | ORD | M25722105 | 67,168 | 0.04 | 31387.0 |
| OVID | REDUCED | OVID THERAPEUTICS INC | COM | 690469101 | 57,297 | 0.03 | 21300.0 |
| - | EVAXION AS | SPONSORED ADS | 29970R303 | 54,442 | 0.03 | 17562.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-17 | 177,260,827 | 87 | 9.703727 | 0.174536 | 15.711041 |
| 2026-03-31 | 2026-05-14 | 249,722,452 | 83 | 6.657016 | 0.05753 | 11.231325 |
| 2025-12-31 | 2026-02-13 | 136,970,409 | 66 | 10.963174 | 0.09142 | 22.545012 |
| 2025-09-30 | 2025-11-13 | 123,007,632 | 58 | 12.012102 | 0.092587 | 22.732134 |
| 2025-03-31 | 2025-05-14 | 102,762,727 | 66 | 5.68527 | 0.042022 | 13.806229 |
| 2024-12-31 | 2025-02-14 | 123,887,533 | 52 | 7.726224 | 0.069002 | 12.578789 |