Frazier Life Sciences Management, L.P.
CIK 0001892134
Annualised vol
11.89189%
Beta
0.117758
HHI
849.483417
Top-10 weight
73.61135%
VaR 95%
1.078494%
VaR 99%
2.314531%
Max drawdown
25.057548%
Matched value
82.062798%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| MIRM | UNCHANGED | 7,679,684 | 7,679,684 | 0.0% | 899,060,606 |
| ERAS | ADDED | 24,975,188 | 24,675,188 | 1.22% | 457,545,444 |
| MBX | UNCHANGED | 6,652,013 | 6,652,013 | 0.0% | 367,191,118 |
| ARQT | UNCHANGED | 9,874,511 | 9,874,511 | 0.0% | 258,909,678 |
| TRVI | REDUCED | 9,939,447 | 9,939,547 | 0.0% | 185,370,687 |
| KRYS | UNCHANGED | 481,307 | 481,307 | 0.0% | 178,887,373 |
| MAZE | ADDED | 5,032,915 | 4,567,274 | 10.2% | 150,182,184 |
| PHAT | UNCHANGED | 12,466,489 | 12,466,489 | 0.0% | 135,261,406 |
| BBIO | REDUCED | 1,548,139 | 3,448,139 | -55.1% | 115,305,393 |
| IRON | UNCHANGED | 1,354,852 | 1,354,852 | 0.0% | 99,093,875 |
| CYTK | UNCHANGED | 1,159,879 | 1,159,879 | 0.0% | 98,810,092 |
| DYN | UNCHANGED | 3,153,082 | 3,153,082 | 0.0% | 70,029,951 |
| ASND | ADDED | 225,155 | 133,333 | 68.87% | 60,053,342 |
| SVRA | UNCHANGED | 9,720,852 | 9,720,852 | 0.0% | 59,880,448 |
| PBLS | NEW | 1,920,805 | - | - | 52,572,433 |
| AURA | ADDED | 7,100,000 | 5,100,000 | 39.22% | 50,410,000 |
| VOR | UNCHANGED | 2,543,939 | 2,543,939 | 0.0% | 46,833,917 |
| ALLO | ADDED | 22,446,668 | 3,796,668 | 491.22% | 46,689,069 |
| TARS | UNCHANGED | 728,644 | 728,644 | 0.0% | 45,860,853 |
| BCRX | UNCHANGED | 4,009,240 | 4,009,240 | 0.0% | 40,092,400 |
| ALKS | UNCHANGED | 700,647 | 700,647 | 0.0% | 36,710,400 |
| ACAD | UNCHANGED | 1,438,198 | 1,438,198 | 0.0% | 36,386,409 |
| ZLAB | UNCHANGED | 1,902,320 | 1,902,320 | 0.0% | 36,144,080 |
| MNKD | ADDED | 6,600,000 | 5,900,000 | 11.86% | 28,116,000 |
| DSGN | NEW | 1,809,854 | - | - | 26,188,587 |
| ACRS | UNCHANGED | 4,925,374 | 4,925,374 | 0.0% | 26,055,228 |
| STTK | NEW | 3,750,000 | - | - | 26,025,000 |
| KLRA | NEW | 1,100,000 | - | - | 24,233,000 |
| GLUE | UNCHANGED | 1,000,000 | 1,000,000 | 0.0% | 24,200,000 |
| LXEO | ADDED | 4,824,725 | 4,424,725 | 9.04% | 22,459,095 |
| RLAY | NEW | 1,015,693 | - | - | 19,003,616 |
| EOLS | UNCHANGED | 2,630,665 | 2,630,665 | 0.0% | 18,256,815 |
| VALN | UNCHANGED | 2,291,666 | 2,291,666 | 0.0% | 11,985,413 |
| AUTL | UNCHANGED | 4,447,910 | 4,447,910 | 0.0% | 7,116,656 |
| XLO | UNCHANGED | 422,505 | 422,505 | 0.0% | 4,047,598 |
| IBIO | UNCHANGED | 1,953,467 | 1,953,467 | 0.0% | 3,418,567 |
| AGIO | CLOSED OUT | 0 | 1,256,080 | -100.0% | 0 |
| RVMD | CLOSED OUT | 0 | 675,686 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| MIRM | UNCHANGED | MIRUM PHARMACEUTICALS INC | COM | 604749101 | 899,060,606 | 19.58 | 7679684.0 |
| - | NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 613,032,889 | 13.35 | 1.8088902E7 | |
| ERAS | ADDED | ERASCA INC | COM | 29479A108 | 457,545,444 | 9.96 | 2.4975188E7 |
| MBX | UNCHANGED | MBX BIOSCIENCES INC | COM | 55287L101 | 367,191,118 | 8.0 | 6652013.0 |
| ARQT | UNCHANGED | ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 258,909,678 | 5.64 | 9874511.0 |
| TRVI | REDUCED | TREVI THERAPEUTICS INC | COM | 89532M101 | 185,370,687 | 4.04 | 9939447.0 |
| KRYS | UNCHANGED | KRYSTAL BIOTECH INC | COM | 501147102 | 178,887,373 | 3.9 | 481307.0 |
| MAZE | ADDED | MAZE THERAPEUTICS INC | COM | 578784100 | 150,182,184 | 3.27 | 5032915.0 |
| PHAT | UNCHANGED | PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | 135,261,406 | 2.95 | 1.2466489E7 |
| - | PALVELLA THERAPEUTICS INC NE | COM | 697947109 | 134,848,368 | 2.94 | 882400.0 | |
| BBIO | REDUCED | BRIDGEBIO PHARMA INC | COM | 10806X102 | 115,305,393 | 2.51 | 1548139.0 |
| IRON | UNCHANGED | DISC MEDICINE INC | COM | 254604101 | 99,093,875 | 2.16 | 1354852.0 |
| CYTK | UNCHANGED | CYTOKINETICS INC | COM NEW | 23282W605 | 98,810,092 | 2.15 | 1159879.0 |
| DYN | UNCHANGED | DYNE THERAPEUTICS INC | COM | 26818M108 | 70,029,951 | 1.53 | 3153082.0 |
| ASND | ADDED | ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | 60,053,342 | 1.31 | 225155.0 |
| SVRA | UNCHANGED | SAVARA INC | COM | 805111101 | 59,880,448 | 1.3 | 9720852.0 |
| PBLS | NEW | PARABILIS MEDICINES INC | COM | 698955101 | 52,572,433 | 1.14 | 1920805.0 |
| AURA | ADDED | AURA BIOSCIENCES INC | COM | 05153U107 | 50,410,000 | 1.1 | 7100000.0 |
| - | ACHIEVE LIFE SCIENCE INC | COM | 004468500 | 49,724,879 | 1.08 | 7614836.0 | |
| VOR | UNCHANGED | VOR BIOPHARMA INC | COM NEW | 929033207 | 46,833,917 | 1.02 | 2543939.0 |
| ALLO | ADDED | ALLOGENE THERAPEUTICS INC | COM | 019770106 | 46,689,069 | 1.02 | 2.2446668E7 |
| TARS | UNCHANGED | TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 45,860,853 | 1.0 | 728644.0 |
| BCRX | UNCHANGED | BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | 40,092,400 | 0.87 | 4009240.0 |
| ALKS | UNCHANGED | ALKERMES PLC | SHS | G01767105 | 36,710,400 | 0.8 | 700647.0 |
| ACAD | UNCHANGED | ACADIA PHARMACEUTICALS INC | COM | 004225108 | 36,386,409 | 0.79 | 1438198.0 |
| ZLAB | UNCHANGED | ZAI LAB LTD | ADR | 98887Q104 | 36,144,080 | 0.79 | 1902320.0 |
| MNKD | ADDED | MANNKIND CORP | COM NEW | 56400P706 | 28,116,000 | 0.61 | 6600000.0 |
| DSGN | NEW | DESIGN THERAPEUTICS INC | COM | 25056L103 | 26,188,587 | 0.57 | 1809854.0 |
| ACRS | UNCHANGED | ACLARIS THERAPEUTICS INC | COM | 00461U105 | 26,055,228 | 0.57 | 4925374.0 |
| STTK | NEW | SHATTUCK LABS INC | COM | 82024L103 | 26,025,000 | 0.57 | 3750000.0 |
| KLRA | NEW | KAILERA THERAPEUTICS INC | COMMON STOCK | 482931102 | 24,233,000 | 0.53 | 1100000.0 |
| GLUE | UNCHANGED | MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 24,200,000 | 0.53 | 1000000.0 |
| LXEO | ADDED | LEXEO THERAPEUTICS INC | COM | 52886X107 | 22,459,095 | 0.49 | 4824725.0 |
| RLAY | NEW | RELAY THERAPEUTICS INC | COM | 75943R102 | 19,003,616 | 0.41 | 1015693.0 |
| EOLS | UNCHANGED | EVOLUS INC | COM | 30052C107 | 18,256,815 | 0.4 | 2630665.0 |
| - | IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 15,391,829 | 0.34 | 484782.0 | |
| VALN | UNCHANGED | VALNEVA SE | SPONSORED ADS | 92025Y103 | 11,985,413 | 0.26 | 2291666.0 |
| - | NEWAMSTERDAM PHARMA COMPANY | *W EXP 99/99/999 | N62509117 | 10,692,116 | 0.23 | 500333.0 | |
| AUTL | UNCHANGED | AUTOLUS THERAPEUTICS LTD | SPON ADS | 05280R100 | 7,116,656 | 0.15 | 4447910.0 |
| XLO | UNCHANGED | XILIO THERAPEUTICS INC | COM | 98422T209 | 4,047,598 | 0.09 | 422505.0 |
| IBIO | UNCHANGED | IBIO INC | COM NEW | 451033708 | 3,418,567 | 0.07 | 1953467.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 4,592,076,814 | 41 | 11.89189 | 0.117758 | 25.057548 |
| 2026-03-31 | 2026-05-15 | 3,886,526,658 | 38 | 12.456005 | 0.167489 | 23.866572 |
| 2025-12-31 | 2026-02-13 | 3,723,154,080 | 40 | 11.329113 | 0.16821 | 20.391359 |
| 2025-09-30 | 2025-11-14 | 3,337,397,700 | 47 | 9.50297 | 0.140608 | 16.926308 |
| 2025-03-31 | 2025-05-15 | 2,187,908,599 | 47 | 9.355629 | 0.141263 | 13.904545 |
| 2024-12-31 | 2025-02-18 | 2,409,201,023 | 50 | 9.575716 | 0.133857 | 21.201974 |