5AM Venture Management, LLC
CIK 0001799883
Annualised vol
14.5461%
Beta
0.112311
HHI
814.491345
Top-10 weight
85.571978%
VaR 95%
1.451337%
VaR 99%
3.075082%
Max drawdown
47.226422%
Matched value
95.35673%
Returns of reported holdings
Loading returns…
Position changes vs prior quarter
What the latest 13F shows bought and sold against the quarter before, by share count.
| Ticker | Change | Shares now | Shares before | Share change % | Value now ($) |
|---|---|---|---|---|---|
| MPLT | UNCHANGED | 950,011 | 950,011 | 0.0% | 34,048,394 |
| TYRA | UNCHANGED | 1,029,298 | 1,029,298 | 0.0% | 32,875,778 |
| TRDA | UNCHANGED | 4,056,379 | 4,056,379 | 0.0% | 29,854,949 |
| PHVS | UNCHANGED | 797,600 | 797,600 | 0.0% | 27,581,008 |
| CAMP | UNCHANGED | 5,869,091 | 5,869,091 | 0.0% | 25,647,928 |
| ARTV | UNCHANGED | 2,353,304 | 2,353,304 | 0.0% | 22,827,049 |
| TECX | UNCHANGED | 606,660 | 606,660 | 0.0% | 20,853,938 |
| ZNTL | UNCHANGED | 3,947,913 | 3,947,913 | 0.0% | 19,147,378 |
| CLDX | UNCHANGED | 497,270 | 497,270 | 0.0% | 18,503,417 |
| EYPT | UNCHANGED | 1,050,000 | 1,050,000 | 0.0% | 15,015,000 |
| BHVN | UNCHANGED | 738,972 | 738,972 | 0.0% | 10,995,903 |
| SKYE | UNCHANGED | 9,681,763 | 9,681,763 | 0.0% | 6,712,366 |
| TARA | UNCHANGED | 1,369,782 | 1,369,782 | 0.0% | 5,232,567 |
| SLN | UNCHANGED | 476,200 | 476,200 | 0.0% | 5,228,676 |
| ERAS | CLOSED OUT | 0 | 3,485,971 | -100.0% | 0 |
| GHRS | CLOSED OUT | 0 | 572,665 | -100.0% | 0 |
| RLYB | CLOSED OUT | 0 | 291,788 | -100.0% | 0 |
Holdings (latest quarter)
| Ticker | Change | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|---|
| MPLT | UNCHANGED | MAPLIGHT THERAPEUTICS INC | COM | 56565P103 | 34,048,394 | 11.83 | 950011.0 |
| TYRA | UNCHANGED | TYRA BIOSCIENCES INC | COM | 90240B106 | 32,875,778 | 11.42 | 1029298.0 |
| TRDA | UNCHANGED | ENTRADA THERAPEUTICS INC | COM | 29384C108 | 29,854,949 | 10.37 | 4056379.0 |
| PHVS | UNCHANGED | PHARVARIS N V | COM | N69605108 | 27,581,008 | 9.58 | 797600.0 |
| CAMP | UNCHANGED | CAMP4 THERAPEUTICS CORP | COM | 13463J101 | 25,647,928 | 8.91 | 5869091.0 |
| ARTV | UNCHANGED | ARTIVA BIOTHERAPEUTICS INC | COM | 04317A107 | 22,827,049 | 7.93 | 2353304.0 |
| TECX | UNCHANGED | TECTONIC THERAPEUTIC INC | COM | 878972108 | 20,853,938 | 7.24 | 606660.0 |
| ZNTL | UNCHANGED | ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 | 19,147,378 | 6.65 | 3947913.0 |
| CLDX | UNCHANGED | CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 18,503,417 | 6.43 | 497270.0 |
| EYPT | UNCHANGED | EYEPOINT INC | COM NEW | 30233G209 | 15,015,000 | 5.22 | 1050000.0 |
| BHVN | UNCHANGED | BIOHAVEN LTD | COM | G1110E107 | 10,995,903 | 3.82 | 738972.0 |
| - | SURROZEN INC | COM NEW | 86889P208 | 7,038,938 | 2.44 | 271250.0 | |
| SKYE | UNCHANGED | SKYE BIOSCIENCE INC | COM NEW | 83086J200 | 6,712,366 | 2.33 | 9681763.0 |
| - | ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 6,328,663 | 2.2 | 3057325.0 | |
| TARA | UNCHANGED | PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 5,232,567 | 1.82 | 1369782.0 |
| SLN | UNCHANGED | SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 5,228,676 | 1.82 | 476200.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 287,891,952 | 16 | 14.5461 | 0.112311 | 47.226422 |
| 2026-03-31 | 2026-05-15 | 360,208,609 | 20 | 15.680553 | 0.122508 | 47.367709 |
| 2025-12-31 | 2026-02-17 | 318,102,880 | 21 | 14.43086 | 0.116492 | 44.577321 |
| 2025-09-30 | 2025-11-14 | 273,045,105 | 25 | 12.029918 | 0.083664 | 37.363216 |
| 2025-03-31 | 2025-05-15 | 264,407,625 | 31 | 12.031652 | 0.116082 | 36.909201 |
| 2024-12-31 | 2025-02-14 | 419,052,435 | 31 | 12.667862 | 0.120179 | 40.979809 |